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Comprehensive Analyses of Tissue-Specific Networks with Implications to Psychiatric Diseases

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Biological Networks and Pathway Analysis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1613))

Abstract

Recent advances in genome sequencing and “omics” technologies are opening new opportunities for improving diagnosis and treatment of human diseases. The precision medicine initiative in particular aims at developing individualized treatment options that take into account individual variability in genes and environment of each person. Systems biology approaches that group genes, transcripts and proteins into functionally meaningful networks will play crucial role in the future of personalized medicine. They will allow comparison of healthy and disease-affected tissues and organs from the same individual, as well as between healthy and disease-afflicted individuals. However, the field faces a multitude of challenges ranging from data integration to statistical and combinatorial issues in data analyses. This chapter describes computational approaches developed by us and the others to tackle challenges in tissue-specific network analyses, with the main focus on psychiatric diseases.

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Authors and Affiliations

  1. Department of Psychiatry, University of California San Diego, 9500 Gilman Drive #0603, La Jolla, CA, 92093, USA

    Guan Ning Lin, Roser Corominas, Hyun-Jun Nam, Jorge Urresti & Lilia M. Iakoucheva

  2. Shanghai Mental Health Center, Shanghai Key Laboratory of Psychotic Disorders and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, P. R. China

    Guan Ning Lin

  3. Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain

    Roser Corominas

  4. Hospital del Mar Research Institute (IMIM), Barcelona, Spain

    Roser Corominas

  5. Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Barcelona, Spain

    Roser Corominas

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  2. Roser Corominas
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  3. Hyun-Jun Nam
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  4. Jorge Urresti
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  5. Lilia M. Iakoucheva
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Correspondence to Lilia M. Iakoucheva .

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  1. Keck School of Medicine, University of Southern California, Los Angeles, California, USA

    Tatiana V. Tatarinova

  2. Prosapia Genetics, Solana Beach, California, USA

    Yuri Nikolsky

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Lin, G.N., Corominas, R., Nam, HJ., Urresti, J., Iakoucheva, L.M. (2017). Comprehensive Analyses of Tissue-Specific Networks with Implications to Psychiatric Diseases. In: Tatarinova, T., Nikolsky, Y. (eds) Biological Networks and Pathway Analysis. Methods in Molecular Biology, vol 1613. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7027-8_15

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