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Antidepressants

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Treatment of Chronic Pain Conditions

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Abstract

Antidepressants have been used as part of the treatment armamentarium for many types of pain syndrome and neuropathic pain. Its pharmacologic effect is mainly due to the inhibition of serotonin, norepinephrine, and epinephrine reuptake. The analgesic effect is usually achieved at a lower dose and is independent of the presence of depression and mood improvement. Adverse reaction related to its use is primarily due to the anticholinergic effect of the drug that includes dry mouth, sedation, and urinary retention. This chapter reviews the role of antidepressants in pain medicine.

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Suggested Reading

  1. Benzon HT. Raj’s practical management of pain. 4th ed. Mosby 2008: Mosby; 2002. p. 643–57. ISBN: 9780323041843.

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  2. Dwrokin RH, O’Connor AB, et al. Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain. 2007;132:237–51.

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  3. Leon AC, Fiedorowicz JG, et al. Risk of suicidal behavior with antidepressants in bipolar and unipolar disorders. J Clin Psychiatry. 2014;75(7):720–7.

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Author information

Authors and Affiliations

  1. Cleveland Clinic, Anesthesia Institute Pain Management, Cleveland, OH, USA

    Alexander Bautista MD

  2. Cleveland Clinic, Anesthesia Institute Pain Management, 9500 Euclid Ave, Dept C-25, Cleveland, OH, 44195, USA

    George C. Chang Chien DO

Authors
  1. Alexander Bautista MD
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  2. George C. Chang Chien DO
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Corresponding author

Correspondence to George C. Chang Chien DO .

Editor information

Editors and Affiliations

  1. Summit Pain Alliance, Santa Rosa, California, USA

    Jason E. Pope

  2. The Spine and Nerve Center of The Virginias, Charleston, West Virginia, USA

    Timothy R Deer

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Bautista, A., Chang Chien, G.C. (2017). Antidepressants. In: Pope, J., Deer, T. (eds) Treatment of Chronic Pain Conditions. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6976-0_23

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  • DOI: https://doi.org/10.1007/978-1-4939-6976-0_23

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-6974-6

  • Online ISBN: 978-1-4939-6976-0

  • eBook Packages: MedicineMedicine (R0)

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