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IL-9 Signaling Pathway: An Update

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Th9 Cells

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1585))

Abstract

Since the discovery of IL-9 almost three decades back as a growth factor, we have come a long way to understand its pleiotropic functions in the immune system. Despite its many functions, IL-9 still remains as an understudied cytokine. In the last decade, renewed emphasis has been provided to understand the biology of IL-9. Any growth factor or cytokine signals via its cognate receptor to mediate biological functions. In this chapter, we discuss the IL-9 signal transduction in different cell types, which would then exert its distinct functions.

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References

  1. Wang X, Lupardus P, Laporte SL, Garcia KC (2009) Structural biology of shared cytokine receptors. Annu Rev Immunol 27:29–60. doi:10.1146/annurev.immunol.24.021605.090616

    Article  PubMed  PubMed Central  Google Scholar 

  2. Goswami R, Kaplan MH (2011) A brief history of IL-9. J Immunol 186(6):3283–3288. doi:10.4049/jimmunol.1003049

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Demoulin JB, Uyttenhove C, Van Roost E, DeLestre B, Donckers D, Van Snick J, Renauld JC (1996) A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9. Mol Cell Biol 16(9):4710–4716

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Yin T, Keller SR, Quelle FW, Witthuhn BA, Tsang ML, Lienhard GE, Ihle JN, Yang YC (1995) Interleukin-9 induces tyrosine phosphorylation of insulin receptor substrate-1 via JAK tyrosine kinases. J Biol Chem 270(35):20497–20502

    Article  CAS  PubMed  Google Scholar 

  5. Demoulin JB, Louahed J, Dumoutier L, Stevens M, Renauld JC (2003) MAP kinase activation by interleukin-9 in lymphoid and mast cell lines. Oncogene 22(12):1763–1770. doi:10.1038/sj.onc.1206253

    Article  CAS  PubMed  Google Scholar 

  6. Richard M, Louahed J, Demoulin JB, Renauld JC (1999) Interleukin-9 regulates NF-kappaB activity through BCL3 gene induction. Blood 93(12):4318–4327

    CAS  PubMed  Google Scholar 

  7. Xiao H, Yin T, Wang XY, Uchida T, Chung J, White MF, Yang YC (2002) Specificity of interleukin-2 receptor gamma chain superfamily cytokines is mediated by insulin receptor substrate-dependent pathway. J Biol Chem 277(10):8091–8098. doi:10.1074/jbc.M106650200

    Article  CAS  PubMed  Google Scholar 

  8. Lejeune D, Demoulin JB, Renauld JC (2001) Interleukin 9 induces expression of three cytokine signal inhibitors: cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin 9 signalling. Biochem J 353(Pt 1):109–116

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Dugas B, Renauld JC, Pene J, Bonnefoy JY, Peti-Frere C, Braquet P, Bousquet J, Van Snick J, Mencia-Huerta JM (1993) Interleukin-9 potentiates the interleukin-4-induced immunoglobulin (IgG, IgM and IgE) production by normal human B lymphocytes. Eur J Immunol 23(7):1687–1692. doi:10.1002/eji.1830230743

    Article  CAS  PubMed  Google Scholar 

  10. Wiener Z, Falus A, Toth S (2004) IL-9 increases the expression of several cytokines in activated mast cells, while the IL-9-induced IL-9 production is inhibited in mast cells of histamine-free transgenic mice. Cytokine 26(3):122–130. doi:10.1016/j.cyto.2004.01.006

    Article  CAS  PubMed  Google Scholar 

  11. Lu L, Leemhuis T, Srour EF, Yang YC (1992) Human interleukin (IL)-9 specifically stimulates proliferation of CD34+++DR+CD33− erythroid progenitors in normal human bone marrow in the absence of serum. Exp Hematol 20(4):418–424

    CAS  PubMed  Google Scholar 

  12. Lemoli RM, Fortuna A, Fogli M, Motta MR, Rizzi S, Benini C, Tura S (1994) Stem cell factor (c-kit ligand) enhances the interleukin-9-dependent proliferation of human CD34+ and CD34+CD33−DR− cells. Exp Hematol 22(9):919–923

    CAS  PubMed  Google Scholar 

  13. Fawaz LM, Sharif-Askari E, Hajoui O, Soussi-Gounni A, Hamid Q, Mazer BD (2007) Expression of IL-9 receptor alpha chain on human germinal center B cells modulates IgE secretion. J Allergy Clin Immunol 120(5):1208–1215. doi:10.1016/j.jaci.2007.08.022

    Article  CAS  PubMed  Google Scholar 

  14. Vink A, Warnier G, Brombacher F, Renauld JC (1999) Interleukin 9-induced in vivo expansion of the B-1 lymphocyte population. J Exp Med 189(9):1413–1423

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Knoops L, Louahed J, Renauld JC (2004) IL-9-induced expansion of B-1b cells restores numbers but not function of B-1 lymphocytes in xid mice. J Immunol 172(10):6101–6106

    Article  CAS  PubMed  Google Scholar 

  16. Petit-Frere C, Dugas B, Braquet P, Mencia-Huerta JM (1993) Interleukin-9 potentiates the interleukin-4-induced IgE and IgG1 release from murine B lymphocytes. Immunology 79(1):146–151

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Lv X, Feng L, Ge X, Lu K, Wang X (2016) Interleukin-9 promotes cell survival and drug resistance in diffuse large B-cell lymphoma. J Exp Clin Cancer Res 35(1):106. doi:10.1186/s13046-016-0374-3

    Article  PubMed  PubMed Central  Google Scholar 

  18. Lv X, Feng L, Fang X, Jiang Y, Wang X (2013) Overexpression of IL-9 receptor in diffuse large B-cell lymphoma. Int J Clin Exp Pathol 6(5):911–916

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Feng LL, Gao JM, Li PP, Wang X (2011) IL-9 contributes to immunosuppression mediated by regulatory T cells and mast cells in B-cell non-hodgkin’s lymphoma. J Clin Immunol 31(6):1084–1094. doi:10.1007/s10875-011-9584-9

    Article  CAS  PubMed  Google Scholar 

  20. Arras M, Huaux F, Vink A, Delos M, Coutelier JP, Many MC, Barbarin V, Renauld JC, Lison D (2001) Interleukin-9 reduces lung fibrosis and type 2 immune polarization induced by silica particles in a murine model. Am J Respir Cell Mol Biol 24(4):368–375. doi:10.1165/ajrcmb.24.4.4249

    Article  CAS  PubMed  Google Scholar 

  21. Arras M, Louahed J, Simoen V, Barbarin V, Misson P, van den Brule S, Delos M, Knoops L, Renauld JC, Lison D, Huaux F (2006) B Lymphocytes are critical for lung fibrosis control and prostaglandin E2 regulation in IL-9 transgenic mice. Am J Respir Cell Mol Biol 34(5):573–580. doi:10.1165/rcmb.2004-0383OC

    Article  CAS  PubMed  Google Scholar 

  22. Matsuzawa S, Sakashita K, Kinoshita T, Ito S, Yamashita T, Koike K (2003) IL-9 enhances the growth of human mast cell progenitors under stimulation with stem cell factor. J Immunol 170(7):3461–3467

    Article  CAS  PubMed  Google Scholar 

  23. Lora JM, Al-Garawi A, Pickard MD, Price KS, Bagga S, Sicoli J, Hodge MR, Gutierrez-Ramos JC, Briskin MJ, Boyce JA (2003) FcepsilonRI-dependent gene expression in human mast cells is differentially controlled by T helper type 2 cytokines. J Allergy Clin Immunol 112(6):1119–1126. doi:10.1016/j.jaci.2003.08.042

    Article  CAS  PubMed  Google Scholar 

  24. Khalil RM, Luz A, Mailhammer R, Moeller J, Mohamed AA, Omran S, Dormer P, Hultner L (1996) Schistosoma mansoni infection in mice augments the capacity for interleukin 3 (IL-3) and IL-9 production and concurrently enlarges progenitor pools for mast cells and granulocytes-macrophages. Infect Immun 64(12):4960–4966

    CAS  PubMed  PubMed Central  Google Scholar 

  25. Pilette C, Ouadrhiri Y, Van Snick J, Renauld JC, Staquet P, Vaerman JP, Sibille Y (2002) Oxidative burst in lipopolysaccharide-activated human alveolar macrophages is inhibited by interleukin-9. Eur Respir J 20(5):1198–1205

    Article  CAS  PubMed  Google Scholar 

  26. Panzner P, Lafitte JJ, Tsicopoulos A, Hamid Q, Tulic MK (2003) Marked up-regulation of T lymphocytes and expression of interleukin-9 in bronchial biopsies from patients With chronic bronchitis with obstruction. Chest 124(5):1909–1915

    Article  CAS  PubMed  Google Scholar 

  27. Tulic MK, Hamid Q (2003) Contribution of the distal lung to the pathologic and physiologic changes in asthma: potential therapeutic target Roger S. Mitchell lecture. Chest 123(3 Suppl):348S–355S

    Article  PubMed  Google Scholar 

  28. Temann UA, Geba GP, Rankin JA, Flavell RA (1998) Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness. J Exp Med 188(7):1307–1320

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Shimbara A, Christodoulopoulos P, Soussi-Gounni A, Olivenstein R, Nakamura Y, Levitt RC, Nicolaides NC, Holroyd KJ, Tsicopoulos A, Lafitte JJ, Wallaert B, Hamid QA (2000) IL-9 and its receptor in allergic and nonallergic lung disease: increased expression in asthma. J Allergy Clin Immunol 105(1 Pt 1):108–115

    Article  CAS  PubMed  Google Scholar 

  30. Gounni AS, Gregory B, Nutku E, Aris F, Latifa K, Minshall E, North J, Tavernier J, Levit R, Nicolaides N, Robinson D, Hamid Q (2000) Interleukin-9 enhances interleukin-5 receptor expression, differentiation, and survival of human eosinophils. Blood 96(6):2163–2171

    CAS  PubMed  Google Scholar 

  31. Louahed J, Zhou Y, Maloy WL, Rani PU, Weiss C, Tomer Y, Vink A, Renauld J, Van Snick J, Nicolaides NC, Levitt RC, Haczku A (2001) Interleukin 9 promotes influx and local maturation of eosinophils. Blood 97(4):1035–1042

    Article  CAS  PubMed  Google Scholar 

  32. Gounni AS, Nutku E, Koussih L, Aris F, Louahed J, Levitt RC, Nicolaides NC, Hamid Q (2000) IL-9 expression by human eosinophils: regulation by IL-1beta and TNF-alpha. J Allergy Clin Immunol 106(3):460–466. doi:10.1067/mai.2000.109172

    Article  CAS  PubMed  Google Scholar 

  33. Temann UA, Ray P, Flavell RA (2002) Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology. J Clin Invest 109(1):29–39. doi:10.1172/JCI13696

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Sitkauskiene B, Radinger M, Bossios A, Johansson AK, Sakalauskas R, Lotvall J (2005) Airway allergen exposure stimulates bone marrow eosinophilia partly via IL-9. Respir Res 6:33. doi:10.1186/1465-9921-6-33

    Article  PubMed  PubMed Central  Google Scholar 

  35. Ying S, Meng Q, Kay AB, Robinson DS (2002) Elevated expression of interleukin-9 mRNA in the bronchial mucosa of atopic asthmatics and allergen-induced cutaneous late-phase reaction: relationships to eosinophils, mast cells and T lymphocytes. Clin Exp Allergy 32(6):866–871

    Article  CAS  PubMed  Google Scholar 

  36. Poulin LF, Richard M, Le Moine A, Kiss R, McKenzie AN, Goldman M, Renauld JC, Van Snick J, Braun MY (2003) Interleukin-9 promotes eosinophilic rejection of mouse heart allografts. Transplantation 76(3):572–577. doi:10.1097/01.TP.0000071201.32424.D2

    Article  CAS  PubMed  Google Scholar 

  37. Gounni AS, Hamid Q, Rahman SM, Hoeck J, Yang J, Shan L (2004) IL-9-mediated induction of eotaxin1/CCL11 in human airway smooth muscle cells. J Immunol 173(4):2771–2779

    Article  CAS  PubMed  Google Scholar 

  38. Fujisawa T, Katsumata H, Kato Y (2008) House dust mite extract induces interleukin-9 expression in human eosinophils. Allergol Int 57(2):141–146. doi:10.2332/allergolint.O-07-498

    Article  CAS  PubMed  Google Scholar 

  39. Kim MS, Cho KA, Cho YJ, Woo SY (2013) Effects of interleukin-9 blockade on chronic airway inflammation in murine asthma models. Allerg Asthma Immunol Res 5(4):197–206. doi:10.4168/aair.2013.5.4.197

    Article  CAS  Google Scholar 

  40. Saeki M, Kaminuma O, Nishimura T, Kitamura N, Mori A, Hiroi T (2016) Th9 cells elicit eosinophil-independent bronchial hyperresponsiveness in mice. Allergol Int 65S:S24–S29. doi:10.1016/j.alit.2016.05.003

    Article  Google Scholar 

  41. Longphre M, Li D, Gallup M, Drori E, Ordonez CL, Redman T, Wenzel S, Bice DE, Fahy JV, Basbaum C (1999) Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells. J Clin Invest 104(10):1375–1382. doi:10.1172/JCI6097

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Damera G, Xia B, Ancha HR, Sachdev GP (2006) IL-9 modulated MUC4 gene and glycoprotein expression in airway epithelial cells. Biosci Rep 26(1):55–67. doi:10.1007/s10540-006-9000-5

    Article  CAS  PubMed  Google Scholar 

  43. Dong Q, Louahed J, Vink A, Sullivan CD, Messler CJ, Zhou Y, Haczku A, Huaux F, Arras M, Holroyd KJ, Renauld JC, Levitt RC, Nicolaides NC (1999) IL-9 induces chemokine expression in lung epithelial cells and baseline airway eosinophilia in transgenic mice. Eur J Immunol 29(7):2130–2139

    Article  CAS  PubMed  Google Scholar 

  44. Little FF, Cruikshank WW, Center DM (2001) Il-9 stimulates release of chemotactic factors from human bronchial epithelial cells. Am J Respir Cell Mol Biol 25(3):347–352. doi:10.1165/ajrcmb.25.3.4349

    Article  PubMed  Google Scholar 

  45. Steenwinckel V, Louahed J, Orabona C, Huaux F, Warnier G, McKenzie A, Lison D, Levitt R, Renauld JC (2007) IL-13 mediates in vivo IL-9 activities on lung epithelial cells but not on hematopoietic cells. J Immunol 178(5):3244–3251

    Article  CAS  PubMed  Google Scholar 

  46. Olcott CM, Han JK, Cunningham TD, Franzese CB (2016) Interleukin-9 and interleukin-17C in chronic rhinosinusitis. Int Forum Allerg Rhinol 6(8):841–847. doi:10.1002/alr.21745

    Article  Google Scholar 

  47. Ciccia F, Guggino G, Ferrante A, Raimondo S, Bignone R, Rodolico V, Peralta S, Van Tok M, Cannizzaro A, Schinocca C, Ruscitti P, Cipriani P, Giacomelli R, Alessandro R, Dieli F, Rizzo A, Baeten D, Triolo G (2016) Interleukin-9 overexpression and Th9 polarization characterize the inflamed gut, the synovial tissue, and the peripheral blood of patients with psoriatic arthritis. Arthritis Rheumatol 68(8):1922–1931. doi:10.1002/art.39649

    Article  CAS  PubMed  Google Scholar 

  48. Kim IK, Kim BS, Koh CH, Seok JW, Park JS, Shin KS, Bae EA, Lee GE, Jeon H, Cho J, Jung Y, Han D, Kwon BS, Lee HY, Chung Y, Kang CY (2015) Glucocorticoid-induced tumor necrosis factor receptor-related protein co-stimulation facilitates tumor regression by inducing IL-9-producing helper T cells. Nat Med 21(9):1010–1017. doi:10.1038/nm.3922

    Article  CAS  PubMed  Google Scholar 

  49. Gu ZW, Wang YX, Cao ZW (2015) T-Helper type 9 cells play a central role in the pathogenesis of respiratory epithelial adenomatoid hamartoma. Medicine (Baltimore) 94(26):e1050. doi:10.1097/MD.0000000000001050

    Article  CAS  Google Scholar 

  50. Hong CH, Chang KL, Wang HJ, Yu HS, Lee CH (2015) IL-9 induces IL-8 production via STIM1 activation and ERK phosphorylation in epidermal keratinocytes: a plausible mechanism of IL-9R in atopic dermatitis. J Dermatol Sci 78(3):206–214. doi:10.1016/j.jdermsci.2015.03.004

    Article  CAS  PubMed  Google Scholar 

  51. Gerlach K, McKenzie AN, Neurath MF, Weigmann B (2015) IL-9 regulates intestinal barrier function in experimental T cell-mediated colitis. Tissue barriers 3(1-2):e983777. doi:10.4161/21688370.2014.983777

    Article  PubMed  PubMed Central  Google Scholar 

  52. Nalleweg N, Chiriac MT, Podstawa E, Lehmann C, Rau TT, Atreya R, Krauss E, Hundorfean G, Fichtner-Feigl S, Hartmann A, Becker C, Mudter J (2015) IL-9 and its receptor are predominantly involved in the pathogenesis of UC. Gut 64(5):743–755. doi:10.1136/gutjnl-2013-305947

    Article  CAS  PubMed  Google Scholar 

  53. Gerlach K, Hwang Y, Nikolaev A, Atreya R, Dornhoff H, Steiner S, Lehr HA, Wirtz S, Vieth M, Waisman A, Rosenbauer F, McKenzie AN, Weigmann B, Neurath MF (2014) TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells. Nat Immunol 15(7):676–686. doi:10.1038/ni.2920

    Article  CAS  PubMed  Google Scholar 

  54. Ma L, Xue HB, Guan XH, Shu CM, Zhang JH, Yu J (2014) Possible pathogenic role of T helper type 9 cells and interleukin (IL)-9 in atopic dermatitis. Clin Exp Immunol 175(1):25–31. doi:10.1111/cei.12198

    Article  CAS  PubMed  Google Scholar 

  55. Parker JC, Thavagnanam S, Skibinski G, Lyons J, Bell J, Heaney LG, Shields MD (2013) Chronic IL9 and IL-13 exposure leads to an altered differentiation of ciliated cells in a well-differentiated paediatric bronchial epithelial cell model. PLoS One 8(5):e61023. doi:10.1371/journal.pone.0061023

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Walker JA, Barlow JL, McKenzie AN (2013) Innate lymphoid cells—how did we miss them? Nat Rev Immunol 13(2):75–87. doi:10.1038/nri3349

    Article  CAS  PubMed  Google Scholar 

  57. Neill DR, Wong SH, Bellosi A, Flynn RJ, Daly M, Langford TK, Bucks C, Kane CM, Fallon PG, Pannell R, Jolin HE, McKenzie AN (2010) Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 464(7293):1367–1370. doi:10.1038/nature08900

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Sherkat R, Yazdani R, Ganjalikhani Hakemi M, Homayouni V, Farahani R, Hosseini M, Rezaei A (2014) Innate lymphoid cells and cytokines of the novel subtypes of helper T cells in asthma. Asia Pac Allergy 4(4):212–221. doi:10.5415/apallergy.2014.4.4.212

    Article  PubMed  PubMed Central  Google Scholar 

  59. Turner JE, Morrison PJ, Wilhelm C, Wilson M, Ahlfors H, Renauld JC, Panzer U, Helmby H, Stockinger B (2013) IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation. J Exp Med 210(13):2951–2965. doi:10.1084/jem.20130071

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Wilhelm C, Hirota K, Stieglitz B, Van Snick J, Tolaini M, Lahl K, Sparwasser T, Helmby H, Stockinger B (2011) An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nat Immunol 12(11):1071–1077. doi:10.1038/ni.2133

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Mohapatra A, Van Dyken SJ, Schneider C, Nussbaum JC, Liang HE, Locksley RM (2016) Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis. Mucosal Immunol 9(1):275–286. doi:10.1038/mi.2015.59

    Article  CAS  PubMed  Google Scholar 

  62. Licona-Limon P, Henao-Mejia J, Temann AU, Gagliani N, Licona-Limon I, Ishigame H, Hao L, Herbert DR, Flavell RA (2013) Th9 cells drive host immunity against gastrointestinal worm infection. Immunity 39(4):744–757. doi:10.1016/j.immuni.2013.07.020

    Article  CAS  PubMed  Google Scholar 

  63. Stassen M, Arnold M, Hultner L, Muller C, Neudorfl C, Reineke T, Schmitt E (2000) Murine bone marrow-derived mast cells as potent producers of IL-9: costimulatory function of IL-10 and kit ligand in the presence of IL-1. J Immunol 164(11):5549–5555

    Article  CAS  PubMed  Google Scholar 

  64. Stassen M, Muller C, Arnold M, Hultner L, Klein-Hessling S, Neudorfl C, Reineke T, Serfling E, Schmitt E (2001) IL-9 and IL-13 production by activated mast cells is strongly enhanced in the presence of lipopolysaccharide: NF-kappa B is decisively involved in the expression of IL-9. J Immunol 166(7):4391–4398

    Article  CAS  PubMed  Google Scholar 

  65. Stassen M, Klein M, Becker M, Bopp T, Neudorfl C, Richter C, Heib V, Klein-Hessling S, Serfling E, Schild H, Schmitt E (2007) p38 MAP kinase drives the expression of mast cell-derived IL-9 via activation of the transcription factor GATA-1. Mol Immunol 44(5):926–933. doi:10.1016/j.molimm.2006.03.019

    Article  CAS  PubMed  Google Scholar 

  66. Lu Y, Hong B, Li H, Zheng Y, Zhang M, Wang S, Qian J, Yi Q (2014) Tumor-specific IL-9-producing CD8+ Tc9 cells are superior effector than type-I cytotoxic Tc1 cells for adoptive immunotherapy of cancers. Proc Natl Acad Sci U S A 111(6):2265–2270. doi:10.1073/pnas.1317431111

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Visekruna A, Ritter J, Scholz T, Campos L, Guralnik A, Poncette L, Raifer H, Hagner S, Garn H, Staudt V, Bopp T, Reuter S, Taube C, Loser K, Huber M (2013) Tc9 cells, a new subset of CD8(+) T cells, support Th2-mediated airway inflammation. Eur J Immunol 43(3):606–618. doi:10.1002/eji.201242825

    Article  CAS  PubMed  Google Scholar 

  68. Kim HS, Chung DH (2013) IL-9-producing invariant NKT cells protect against DSS-induced colitis in an IL-4-dependent manner. Mucosal Immunol 6(2):347–357. doi:10.1038/mi.2012.77

    Article  CAS  PubMed  Google Scholar 

  69. Jones TG, Hallgren J, Humbles A, Burwell T, Finkelman FD, Alcaide P, Austen KF, Gurish MF (2009) Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells. J Immunol 183(8):5251–5260. doi:10.4049/jimmunol.0901471

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Chang HC, Sehra S, Goswami R, Yao W, Yu Q, Stritesky GL, Jabeen R, McKinley C, Ahyi AN, Han L, Nguyen ET, Robertson MJ, Perumal NB, Tepper RS, Nutt SL, Kaplan MH (2010) The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat Immunol 11(6):527–534. doi:10.1038/ni.1867

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  71. Nowak EC, Weaver CT, Turner H, Begum-Haque S, Becher B, Schreiner B, Coyle AJ, Kasper LH, Noelle RJ (2009) IL-9 as a mediator of Th17-driven inflammatory disease. J Exp Med 206(8):1653–1660. doi:10.1084/jem.20090246

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Lu LF, Lind EF, Gondek DC, Bennett KA, Gleeson MW, Pino-Lagos K, Scott ZA, Coyle AJ, Reed JL, Van Snick J, Strom TB, Zheng XX, Noelle RJ (2006) Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature 442(7106):997–1002. doi:10.1038/nature05010

    Article  CAS  PubMed  Google Scholar 

  73. Stassen M, Schmitt E, Bopp T (2012) From interleukin-9 to T helper 9 cells. Ann N Y Acad Sci 1247:56–68. doi:10.1111/j.1749-6632.2011.06351.x

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Bioengineering, National Institute of Technology, NIT-Agartala, Jirania, 799046, Tripura, India

    Dijendra Nath Roy

  2. School of Bio Science, Sir JC Bose Laboratory Complex, Indian Institute of Technology, Kharagpur, 721302, West Bengal, India

    Ritobrata Goswami Ph.D.

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  1. School of Bio Science, Sir JC Bose Laboratory Complex, Indian Institute of Technology, Kharagpur, West Bengal, India

    Ritobrata Goswami

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Roy, D.N., Goswami, R. (2017). IL-9 Signaling Pathway: An Update. In: Goswami, R. (eds) Th9 Cells. Methods in Molecular Biology, vol 1585. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6877-0_3

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  • DOI: https://doi.org/10.1007/978-1-4939-6877-0_3

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