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Overview of Mammary Gland Development: A Comparison of Mouse and Human

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Mammary Gland Development

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1501))

Abstract

The mouse mammary gland is widely used as a model for human breast cancer and has greatly added to our understanding of the molecular mechanisms involved in breast cancer development and progression. To fully appreciate the validity and limitations of the mouse model, it is essential to be aware of the similarities and also the differences that exist between the mouse mammary gland and the human breast. This introduction therefore describes the parallels and contrasts in mouse mammary gland and human breast morphogenesis from an early embryonic phase through to puberty, adulthood, pregnancy, parturition, and lactation, and finally the regressive stage of involution.

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Authors and Affiliations

  1. Institute of Cancer Sciences, College of MVLS, University of Glasgow, Glasgow, UK

    Torsten Stein

  2. UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, 4, Ireland

    Sara McNally

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  1. Sara McNally
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  2. Torsten Stein
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Correspondence to Sara McNally .

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Editors and Affiliations

  1. School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin, Ireland

    Finian Martin

  2. Institute of Cancer Sciences College of MVLS University of Glasgow, Glasgow, United Kingdom

    Torsten Stein

  3. Division of Oncology-Pathology, Lund University Cancer Center/Medicon Village, Lund, Sweden

    Jillian Howlin

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McNally, S., Stein, T. (2017). Overview of Mammary Gland Development: A Comparison of Mouse and Human. In: Martin, F., Stein, T., Howlin, J. (eds) Mammary Gland Development. Methods in Molecular Biology, vol 1501. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6475-8_1

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  • DOI: https://doi.org/10.1007/978-1-4939-6475-8_1

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