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Maternal Obesity Effects on the Risk of Allergic Diseases in Offspring

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Parental Obesity: Intergenerational Programming and Consequences

Part of the book series: Physiology in Health and Disease ((PIHD))

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Abstract

Parallel increases in prevalence of both obesity and allergic disease have occurred in recent decades, suggesting that these conditions may be causally linked. Allergic diseases are often established in childhood. Factors acting in early life, including the prenatal period, might influence the risk of developing these conditions. Epidemiological data partially support associations between maternal obesity and allergic disease. These associations appear largely restricted to asthma, not all of which is allergic. Maternal obesity could directly influence respiratory or immune development predisposing to asthma and, potentially, other allergic diseases via immune modifying effects of adipokines, epigenetic effects, or effects upon the maternal and fetal microbiomes. Indirect effects of maternal obesity which might, in turn, influence the risk of developing allergic disease include pregnancy complications and obesity in offspring. Finally, associations between maternal obesity and allergic diseases in offspring might reflect shared genetics, gene–environment interactions or confounding by shared diet or habitual activity. Given the considerable impact of allergic asthma and other allergic diseases upon individuals and health-care systems, identifying a causal pathway between maternal weight and allergic diseases would be of great importance for public health. Further research is needed to identify the underlying mechanisms, effect modifiers and long-term consequences into adulthood.

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References

  1. Eder W, Ege MJ, von Mutius E (2006) The asthma epidemic. N Engl J Med 355(21):2226–2235

    Article  CAS  PubMed  Google Scholar 

  2. Pearce N, Ait-Khaled N, Beasley R, Mallol J, Keil U, Mitchell E et al (2007) Worldwide trends in the prevalence of asthma symptoms: phase III of the international study of asthma and allergies in childhood (ISAAC). Thorax 62(9):758–766

    Article  PubMed  PubMed Central  Google Scholar 

  3. Prescott SL, Pawankar R, Allen KJ, Campbell DE, Sinn J, Fiocchi A et al (2013) A global survey of changing patterns of food allergy burden in children. World Allergy Organ J 6(1):21

    Article  PubMed  PubMed Central  Google Scholar 

  4. Gaillard R, Durmus B, Hofman A, Mackenbach JP, Steegers EA, Jaddoe VW (2013) Risk factors and outcomes of maternal obesity and excessive weight gain during pregnancy. Obesity (Silver Spring) 21(5):1046–1055

    Article  Google Scholar 

  5. McDonald SD, Han Z, Mulla S, Beyene J, Knowledge Synthesis G (2010) Overweight and obesity in mothers and risk of preterm birth and low birth weight infants: systematic review and meta-analyses. BMJ 341:c3428

    Article  PubMed  PubMed Central  Google Scholar 

  6. Rajasingam D, Seed PT, Briley AL, Shennan AH, Poston L (2009) A prospective study of pregnancy outcome and biomarkers of oxidative stress in nulliparous obese women. Am J Obstet Gynecol 200(4):395.e1–395.e9

    Article  CAS  Google Scholar 

  7. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Lancet 351(9111):1225–1232 (1998)

    Google Scholar 

  8. Lai CK, Beasley R, Crane J, Foliaki S, Shah J, Weiland S et al (2009) Global variation in the prevalence and severity of asthma symptoms: phase three of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 64(6):476–483

    Article  CAS  PubMed  Google Scholar 

  9. To T, Stanojevic S, Moores G, Gershon AS, Bateman ED, Cruz AA et al (2012) Global asthma prevalence in adults: findings from the cross-sectional world health survey. BMC Public Health 12:204

    Article  PubMed  PubMed Central  Google Scholar 

  10. von Mutius E, Martinez FD, Fritzsch C, Nicolai T, Roell G, Thiemann HH (1994) Prevalence of asthma and atopy in two areas of West and East Germany. Am J Respir Crit Care Med 149(2 Pt 1):358–364

    Article  Google Scholar 

  11. Bjorksten B, Dumitrascu D, Foucard T, Khetsuriani N, Khaitov R, Leja M et al (1998) Prevalence of childhood asthma, rhinitis and eczema in Scandinavia and Eastern Europe. Eur Respir J 12(2):432–437

    Article  CAS  PubMed  Google Scholar 

  12. Addo Yobo EO, Custovic A, Taggart SC, Asafo-Agyei AP, Woodcock A (1997) Exercise induced bronchospasm in Ghana: differences in prevalence between urban and rural schoolchildren. Thorax 52(2):161–165

    Article  CAS  PubMed  Google Scholar 

  13. Krause T, Koch A, Friborg J, Poulsen LK, Kristensen B, Melbye M (2002) Frequency of atopy in the Arctic in 1987 and 1998. Lancet 360(9334):691–692

    Article  PubMed  Google Scholar 

  14. Krause TG, Koch A, Poulsen LK, Kristensen B, Olsen OR, Melbye M (2002) Atopic sensitization among children in an arctic environment. Clin Exp Allergy 32(3):367–372

    Article  CAS  PubMed  Google Scholar 

  15. Andersen S, Mulvad G, Pedersen HS, Laurberg P (2004) Gender diversity in developing overweight over 35 years of Westernization in an Inuit hunter cohort and ethno-specific body mass index for evaluation of body-weight abnormalities. Eur J Endocrinol 151(6):735–740

    Article  CAS  PubMed  Google Scholar 

  16. Public Health England (2015) UK and Ireland prevalence and trends http://www.hscic.gov.uk/catalogue/PUB16988/obes-phys-acti-diet-eng-2015.pdf

  17. World Health Organization (2007) Global strategy on diet, physical activity and health. World Health Organization, Geneva http://www.who.int/dietphysicalactivity/M&E-2008-web.pdf

  18. NHS Information Centre (2008) Health survey for England 2006: CVD and risk factors adults, obesity and risk factors children. NHS Information Centre, Leeds

    Google Scholar 

  19. Thangaratinam S, Jolly K (2010) Obesity in pregnancy: a review of reviews on the effectiveness of interventions. BJOG 117(11):1309–1312

    Article  CAS  PubMed  Google Scholar 

  20. Reichman NE, Nepomnyaschy L (2008) Maternal pre-pregnancy obesity and diagnosis of asthma in offspring at age 3 years. Matern Child Health J 12(6):725–733

    Article  PubMed  Google Scholar 

  21. Haberg SE, Stigum H, London SJ, Nystad W, Nafstad P (2009) Maternal obesity in pregnancy and respiratory health in early childhood. Paediatr Perinat Epidemiol 23(4):352–362

    Article  PubMed  PubMed Central  Google Scholar 

  22. Kumar R, Story RE, Pongracic JA, Hong X, Arguelles L, Wang G et al (2010) Maternal pre-pregnancy obesity and recurrent wheezing in early childhood. Pediatr Allergy Immunol Pulmonol 23(3):183–190

    Article  PubMed  PubMed Central  Google Scholar 

  23. Caudri D, Savenije OE, Smit HA, Postma DS, Koppelman GH, Wijga AH et al (2013) Perinatal risk factors for wheezing phenotypes in the first 8 years of life. Clin Exp Allergy 43(12):1395–1405

    Article  CAS  PubMed  Google Scholar 

  24. Leermakers ET, Sonnenschein-van der Voort AM, Gaillard R, Hofman A, de Jongste JC, Jaddoe VW et al (2013) Maternal weight, gestational weight gain and preschool wheezing: the generation R study. Eur Respir J 42(5):1234–1243

    Article  PubMed  Google Scholar 

  25. Wright RJ, Fisher K, Chiu YH, Wright RO, Fein R, Cohen S et al (2013) Disrupted prenatal maternal cortisol, maternal obesity, and childhood wheeze. Insights into prenatal programming. Am J Respir Crit Care Med 187(11):1186–1193

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Pike KC, Inskip HM, Robinson SM, Cooper C, Godfrey KM, Roberts G et al (2013) The relationship between maternal adiposity and infant weight gain, and childhood wheeze and atopy. Thorax 68(4):372–379

    Article  PubMed  PubMed Central  Google Scholar 

  27. de Vries A, Reynolds RM, Seckl JR, van der Wal M, Bonsel GJ, Vrijkotte TG (2014) Increased maternal BMI is associated with infant wheezing in early life: a prospective cohort study. J Dev Orig Health Dis 5(5):351–360

    Article  PubMed  CAS  Google Scholar 

  28. Eising JB, Uiterwaal CS, van der Ent CK (2015) Maternal body mass index, neonatal lung function and respiratory symptoms in childhood. Eur Respir J 46(5):1342–1349

    Article  CAS  PubMed  Google Scholar 

  29. Zugna D, Galassi C, Annesi-Maesano I, Baiz N, Barros H, Basterrechea M et al (2015) Maternal complications in pregnancy and wheezing in early childhood: a pooled analysis of 14 birth cohorts. Int J Epidemiol 44(1):199–208

    Article  PubMed  Google Scholar 

  30. Scholtens S, Wijga AH, Brunekreef B, Kerkhof M, Postma DS, Oldenwening M et al (2010) Maternal overweight before pregnancy and asthma in offspring followed for 8 years. Int J Obes (Lond) 34(4):606–613

    Article  CAS  Google Scholar 

  31. Patel SP, Rodriguez A, Little MP, Elliott P, Pekkanen J, Hartikainen AL et al (2012) Associations between pre-pregnancy obesity and asthma symptoms in adolescents. J Epidemiol Community Health 66(9):809–814

    Article  PubMed  Google Scholar 

  32. Harpsoe MC, Basit S, Bager P, Wohlfahrt J, Benn CS, Nohr EA et al (2013) Maternal obesity, gestational weight gain, and risk of asthma and atopic disease in offspring: a study within the Danish National Birth Cohort. J Allergy Clin Immunol 131(4):1033–1040

    Article  PubMed  Google Scholar 

  33. Halonen M, Lohman IC, Stern DA, Ellis WL, Rothers J, Wright AL (2013) Perinatal tumor necrosis factor-alpha production, influenced by maternal pregnancy weight gain, predicts childhood asthma. Am J Respir Crit Care Med 188(1):35–41

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Ekstrom S, Magnusson J, Kull I, Lind T, Almqvist C, Melen E et al (2015) Maternal body mass index in early pregnancy and offspring asthma, rhinitis and eczema up to 16 years of age. Clin Exp Allergy 45(1):283–291

    Article  CAS  PubMed  Google Scholar 

  35. Forno E, Young OM, Kumar R, Simhan H, Celedon JC (2014) Maternal obesity in pregnancy, gestational weight gain, and risk of childhood asthma. Pediatrics 134(2):e535–e546

    Article  PubMed  PubMed Central  Google Scholar 

  36. Oliveti JF, Kercsmar CM, Redline S (1996) Pre- and perinatal risk factors for asthma in inner city African-American children. Am J Epidemiol 143(6):570–577

    Article  CAS  PubMed  Google Scholar 

  37. Rusconi F, Galassi C, Forastiere F, Bellasio M, De Sario M, Ciccone G et al (2007) Maternal complications and procedures in pregnancy and at birth and wheezing phenotypes in children. Am J Respir Crit Care Med 175(1):16–21

    Article  PubMed  Google Scholar 

  38. Kumari AS (2001) Pregnancy outcome in women with morbid obesity. Int J Gynaecol Obstet 73(2):101–107

    Article  CAS  PubMed  Google Scholar 

  39. Sebire NJ, Jolly M, Harris JP, Wadsworth J, Joffe M, Beard RW et al (2001) Maternal obesity and pregnancy outcome: a study of 287,213 pregnancies in London. Int J Obes Relat Metab Disord 25(8):1175–1182

    Article  CAS  PubMed  Google Scholar 

  40. Catov JM, Ness RB, Kip KE, Olsen J (2007) Risk of early or severe pre-eclampsia related to pre-existing conditions. Int J Epidemiol 36(2):412–419

    Article  PubMed  Google Scholar 

  41. Sonnenschein-van der Voort AM, Arends LR, de Jongste JC, Annesi-Maesano I, Arshad SH, Barros H et al (2014) Preterm birth, infant weight gain, and childhood asthma risk: a meta-analysis of 147,000 European children. J Allergy Clin Immunol 133(5):1317–1329

    Article  PubMed  PubMed Central  Google Scholar 

  42. Kolokotroni O, Middleton N, Gavatha M, Lamnisos D, Priftis KN, Yiallouros PK (2012) Asthma and atopy in children born by caesarean section: effect modification by family history of allergies—a population based cross-sectional study. BMC Pediatr 12:179

    Article  PubMed  PubMed Central  Google Scholar 

  43. Thavagnanam S, Fleming J, Bromley A, Shields MD, Cardwell CR (2008) A meta-analysis of the association between Caesarean section and childhood asthma. Clin Exp Allergy 38(4):629–633

    Article  CAS  PubMed  Google Scholar 

  44. Kumar R, Ouyang F, Story RE, Pongracic JA, Hong X, Wang G et al (2009) Gestational diabetes, atopic dermatitis, and allergen sensitization in early childhood. J Allergy Clin Immunol 124(5):1031.e1–1038.e4

    Article  CAS  Google Scholar 

  45. Bager P, Wohlfahrt J, Westergaard T (2008) Caesarean delivery and risk of atopy and allergic disease: meta-analyses. Clin Exp Allergy 38(4):634–642

    Article  CAS  PubMed  Google Scholar 

  46. Duijts L, Reiss IK, Brusselle G, de Jongste JC (2014) Early origins of chronic obstructive lung diseases across the life course. Eur J Epidemiol 29(12):871–885

    Article  PubMed  Google Scholar 

  47. Harb H, Renz H (2015) Update on epigenetics in allergic disease. J Allergy Clin Immunol 135(1):15–24

    Article  CAS  PubMed  Google Scholar 

  48. Davey Smith G, Leary S, Ness A, Lawlor DA (2009) Challenges and novel approaches in the epidemiological study of early life influences on later disease. Adv Exp Med Biol 646:1–14

    Article  PubMed  Google Scholar 

  49. Smith GD, Ebrahim S (2003) ‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 32(1):1–22

    Article  PubMed  Google Scholar 

  50. Granell R, Henderson AJ, Evans DM, Smith GD, Ness AR, Lewis S et al (2014) Effects of BMI, fat mass, and lean mass on asthma in childhood: a Mendelian randomization study. PLoS Med 11(7):e1001669

    Article  PubMed  PubMed Central  Google Scholar 

  51. Thangaratinam S, Rogozinska E, Jolly K, Glinkowski S, Roseboom T, Tomlinson JW et al (2012) Effects of interventions in pregnancy on maternal weight and obstetric outcomes: meta-analysis of randomised evidence. BMJ 344:e2088

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Oken E (2009) Maternal and child obesity: the causal link. Obstet Gynecol Clin North Am 36(2):361–377, ix–x

    Article  PubMed  Google Scholar 

  53. Curat CA, Miranville A, Sengenes C, Diehl M, Tonus C, Busse R et al (2004) From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes. Diabetes 53(5):1285–1292

    Article  CAS  PubMed  Google Scholar 

  54. Reutrakul S, Zaidi N, Wroblewski K, Kay HH, Ismail M, Ehrmann DA et al (2013) Interactions between pregnancy, obstructive sleep apnea, and gestational diabetes mellitus. J Clin Endocrinol Metab 98(10):4195–4202

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Considine RV, Caro JF (1997) Leptin and the regulation of body weight. Int J Biochem Cell Biol 29(11):1255–1272

    Article  CAS  PubMed  Google Scholar 

  56. Hendler I, Blackwell SC, Mehta SH, Whitty JE, Russell E, Sorokin Y et al (2005) The levels of leptin, adiponectin, and resistin in normal weight, overweight, and obese pregnant women with and without preeclampsia. Am J Obstet Gynecol 193(3 Pt 2):979–983

    Article  CAS  PubMed  Google Scholar 

  57. De Rosa V, Procaccini C, Cali G, Pirozzi G, Fontana S, Zappacosta S et al (2007) A key role of leptin in the control of regulatory T cell proliferation. Immunity 26(2):241–255

    Article  PubMed  CAS  Google Scholar 

  58. Kumada M, Kihara S, Ouchi N, Kobayashi H, Okamoto Y, Ohashi K et al (2004) Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages. Circulation 109(17):2046–2049

    Article  CAS  PubMed  Google Scholar 

  59. Challier JC, Basu S, Bintein T, Minium J, Hotmire K, Catalano PM et al (2008) Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta. Placenta 29(3):274–281

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Bugatto F, Fernandez-Deudero A, Bailen A, Fernandez-Macias R, Hervias-Vivancos B, Bartha JL (2010) Second-trimester amniotic fluid proinflammatory cytokine levels in normal and overweight women. Obstet Gynecol 115(1):127–133

    Article  CAS  PubMed  Google Scholar 

  61. Yokoyama A, Kohno N, Fujino S, Hamada H, Inoue Y, Fujioka S et al (1995) Circulating interleukin-6 levels in patients with bronchial asthma. Am J Respir Crit Care Med 151(5):1354–1358

    Article  CAS  PubMed  Google Scholar 

  62. Salvi S, Semper A, Blomberg A, Holloway J, Jaffar Z, Papi A et al (1999) Interleukin-5 production by human airway epithelial cells. Am J Respir Cell Mol Biol 20(5):984–991

    Article  CAS  PubMed  Google Scholar 

  63. Hersoug LG, Linneberg A (2007) The link between the epidemics of obesity and allergic diseases: does obesity induce decreased immune tolerance? Allergy 62(10):1205–1213

    Article  CAS  PubMed  Google Scholar 

  64. Wilson RM, Marshall NE, Jeske DR, Purnell JQ, Thornburg K, Messaoudi I (2015) Maternal obesity alters immune cell frequencies and responses in umbilical cord blood samples. Pediatr Allergy Immunol 26(4):344–351

    Article  PubMed  Google Scholar 

  65. Bruno A, Pace E, Chanez P, Gras D, Vachier I, Chiappara G et al (2009) Leptin and leptin receptor expression in asthma. J Allergy Clin Immunol 124(2):230–7, 7 e1–4

    Google Scholar 

  66. Miller M, Cho JY, Pham A, Ramsdell J, Broide DH (2009) Adiponectin and functional adiponectin receptor 1 are expressed by airway epithelial cells in chronic obstructive pulmonary disease. J Immunol 182(1):684–691

    Article  CAS  PubMed  Google Scholar 

  67. Bergen HT, Cherlet TC, Manuel P, Scott JE (2002) Identification of leptin receptors in lung and isolated fetal type II cells. Am J Respir Cell Mol Biol 27(1):71–77

    Article  CAS  PubMed  Google Scholar 

  68. Shore SA, Rivera-Sanchez YM, Schwartzman IN, Johnston RA (2003) Responses to ozone are increased in obese mice. J Appl Physiol 95(3):938–945

    Article  CAS  PubMed  Google Scholar 

  69. Shore SA, Terry RD, Flynt L, Xu A, Hug C (2006) Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol 118(2):389–395

    Article  CAS  PubMed  Google Scholar 

  70. Eising JB, Uiterwaal CS, Evelein AM, Visseren FL, van der Ent CK (2014) Relationship between leptin and lung function in young healthy children. Eur Respir J 43(4):1189–1192

    Article  CAS  PubMed  Google Scholar 

  71. Kim KW, Shin YH, Lee KE, Kim ES, Sohn MH, Kim KE (2008) Relationship between adipokines and manifestations of childhood asthma. Pediatr Allergy Immunol 19(6):535–540

    Article  CAS  PubMed  Google Scholar 

  72. Hislop AA, Haworth SG (1989) Airway size and structure in the normal fetal and infant lung and the effect of premature delivery and artificial ventilation. Am Rev Respir Dis 140(6):1717–1726

    Article  CAS  PubMed  Google Scholar 

  73. Maritz GS, Cock ML, Louey S, Suzuki K, Harding R (2004) Fetal growth restriction has long-term effects on postnatal lung structure in sheep. Pediatr Res 55(2):287–295

    Article  PubMed  Google Scholar 

  74. Joyce BJ, Louey S, Davey MG, Cock ML, Hooper SB, Harding R (2001) Compromised respiratory function in postnatal lambs after placental insufficiency and intrauterine growth restriction. Pediatr Res 50(5):641–649

    Article  CAS  PubMed  Google Scholar 

  75. Steegers EA, von Dadelszen P, Duvekot JJ, Pijnenborg R (2010) Pre-eclampsia. Lancet 376(9741):631–644

    Article  PubMed  Google Scholar 

  76. Tang JR, Karumanchi SA, Seedorf G, Markham N, Abman SH (2012) Excess soluble vascular endothelial growth factor receptor-1 in amniotic fluid impairs lung growth in rats: linking preeclampsia with bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol 302(1):L36–L46

    Article  CAS  PubMed  Google Scholar 

  77. Gao XL, Yang HX, Zhao Y (2008) Variations of tumor necrosis factor-alpha, leptin and adiponectin in mid-trimester of gestational diabetes mellitus. Chin Med J (Engl) 121(8):701–705

    CAS  Google Scholar 

  78. Ly NP, Ruiz-Perez B, Onderdonk AB, Tzianabos AO, Litonjua AA, Liang C et al (2006) Mode of delivery and cord blood cytokines: a birth cohort study. Clin Mol Allergy 4:13

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  79. Neaville WA, Tisler C, Bhattacharya A, Anklam K, Gilbertson-White S, Hamilton R et al (2003) Developmental cytokine response profiles and the clinical and immunologic expression of atopy during the first year of life. J Allergy Clin Immunol 112(4):740–746

    Article  CAS  PubMed  Google Scholar 

  80. Abrahamsson TR, Sandberg Abelius M, Forsberg A, Bjorksten B, Jenmalm MC (2011) A Th1/Th2-associated chemokine imbalance during infancy in children developing eczema, wheeze and sensitization. Clin Exp Allergy 41(12):1729–1739

    Article  CAS  PubMed  Google Scholar 

  81. Sjogren YM, Jenmalm MC, Bottcher MF, Bjorksten B, Sverremark-Ekstrom E (2009) Altered early infant gut microbiota in children developing allergy up to 5 years of age. Clin Exp Allergy 39(4):518–526

    Article  CAS  PubMed  Google Scholar 

  82. Wang M, Karlsson C, Olsson C, Adlerberth I, Wold AE, Strachan DP et al (2008) Reduced diversity in the early fecal microbiota of infants with atopic eczema. J Allergy Clin Immunol 121(1):129–134

    Article  PubMed  Google Scholar 

  83. Forno E, Onderdonk AB, McCracken J, Litonjua AA, Laskey D, Delaney ML et al (2008) Diversity of the gut microbiota and eczema in early life. Clini Mol Allergy 6:11

    Article  CAS  Google Scholar 

  84. Blumer N, Sel S, Virna S, Patrascan CC, Zimmermann S, Herz U et al (2007) Perinatal maternal application of Lactobacillus rhamnosus GG suppresses allergic airway inflammation in mouse offspring. Clin Exp Allergy 37(3):348–357

    Article  CAS  PubMed  Google Scholar 

  85. Conrad ML, Ferstl R, Teich R, Brand S, Blumer N, Yildirim AO et al (2009) Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78. J Exp Med 206(13):2869–2877

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  86. Collado MC, Isolauri E, Laitinen K, Salminen S (2008) Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women. Am J Clin Nutr 88(4):894–899

    CAS  PubMed  Google Scholar 

  87. Urwin HJ, Miles EA, Noakes PS, Kremmyda LS, Vlachava M, Diaper ND et al (2014) Effect of salmon consumption during pregnancy on maternal and infant faecal microbiota, secretory IgA and calprotectin. Br J Nutr 111(5):773–784

    Article  CAS  PubMed  Google Scholar 

  88. Collado MC, Isolauri E, Laitinen K, Salminen S (2010) Effect of mother’s weight on infant’s microbiota acquisition, composition, and activity during early infancy: a prospective follow-up study initiated in early pregnancy. Am J Clin Nutr 92(5):1023–1030

    Article  CAS  PubMed  Google Scholar 

  89. Hollingsworth JW, Maruoka S, Boon K, Garantziotis S, Li Z, Tomfohr J et al (2008) In utero supplementation with methyl donors enhances allergic airway disease in mice. J Clin Invest 118(10):3462–3469

    CAS  PubMed  PubMed Central  Google Scholar 

  90. Soubry A, Murphy SK, Wang F, Huang Z, Vidal AC, Fuemmeler BF et al (2015) Newborns of obese parents have altered DNA methylation patterns at imprinted genes. Int J Obes (Lond) 39(4):650–657

    Article  CAS  Google Scholar 

  91. Takahashi M, Kamei Y, Ezaki O (2005) Mest/Peg1 imprinted gene enlarges adipocytes and is a marker of adipocyte size. Am J Physiol Endocrinol Metab 288(1):E117–E124

    Article  CAS  PubMed  Google Scholar 

  92. Hallstrand TS, Fischer ME, Wurfel MM, Afari N, Buchwald D, Goldberg J (2005) Genetic pleiotropy between asthma and obesity in a community-based sample of twins. J Allergy Clin Immunol 116(6):1235–1241

    Article  PubMed  PubMed Central  Google Scholar 

  93. Thomsen SF, Ulrik CS, Kyvik KO, Sorensen TI, Posthuma D, Skadhauge LR et al (2007) Association between obesity and asthma in a twin cohort. Allergy 62(10):1199–1204

    Article  CAS  PubMed  Google Scholar 

  94. Weiss ST, Raby BA (2004) Asthma genetics 2003. Hum Mol Genet 13(1):R83–R89

    Article  CAS  PubMed  Google Scholar 

  95. Tantisira KG, Weiss ST (2001) Complex interactions in complex traits: obesity and asthma. Thorax 56(Suppl 2):ii64–ii73

    PubMed  PubMed Central  Google Scholar 

  96. Pausova Z, Deslauriers B, Gaudet D, Tremblay J, Kotchen TA, Larochelle P et al (2000) Role of tumor necrosis factor-alpha gene locus in obesity and obesity-associated hypertension in French Canadians. Hypertension 36(1):14–19

    Article  CAS  PubMed  Google Scholar 

  97. Noguchi E, Yokouchi Y, Shibasaki M, Inudou M, Nakahara S, Nogami T et al (2002) Association between TNFA polymorphism and the development of asthma in the Japanese population. Am J Respir Crit Care Med 166(1):43–46

    Article  PubMed  Google Scholar 

  98. Li Kam Wa TC, Mansur AH, Britton J, Williams G, Pavord I, Richards K et al (1999) Association between—308 tumour necrosis factor promoter polymorphism and bronchial hyperreactivity in asthma. Clin Exp Allergy 29(9):1204–1208

    Article  CAS  PubMed  Google Scholar 

  99. Melen E, Granell R, Kogevinas M, Strachan D, Gonzalez JR, Wjst M et al (2013) Genome-wide association study of body mass index in 23 000 individuals with and without asthma. Clin Exp Allergy 43(4):463–474

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  100. Sleiman PM, Flory J, Imielinski M, Bradfield JP, Annaiah K, Willis-Owen SA et al (2010) Variants of DENND1B associated with asthma in children. N Engl J Med 362(1):36–44

    Article  CAS  PubMed  Google Scholar 

  101. Laster LE, Lovelady CA, West DG, Wiltheiss GA, Brouwer RJ, Stroo M et al (2013) Diet quality of overweight and obese mothers and their preschool children. J Acad Nutr Diet 113(11):1476–1483

    Article  PubMed  PubMed Central  Google Scholar 

  102. Robinson S, Marriott L, Poole J, Crozier S, Borland S, Lawrence W et al (2007) Dietary patterns in infancy: the importance of maternal and family influences on feeding practice. Br J Nutr 98(5):1029–1037

    Article  CAS  PubMed  Google Scholar 

  103. Hesketh KR, Goodfellow L, Ekelund U, McMinn AM, Godfrey KM, Inskip HM et al (2014) Activity levels in mothers and their preschool children. Pediatrics 133(4):e973–e980

    Article  PubMed  Google Scholar 

  104. Chatzi L, Kogevinas M (2009) Prenatal and childhood Mediterranean diet and the development of asthma and allergies in children. Public Health Nutr 12(9A):1629–1634

    Article  PubMed  Google Scholar 

  105. Willers SM, Wijga AH, Brunekreef B, Scholtens S, Postma DS, Kerkhof M et al (2011) Childhood diet and asthma and atopy at 8 years of age: the PIAMA birth cohort study. Eur Respir J 37(5):1060–1067

    Article  CAS  PubMed  Google Scholar 

  106. Chen YC, Tu YK, Huang KC, Chen PC, Chu DC, Lee YL (2014) Pathway from central obesity to childhood asthma. Physical fitness and sedentary time are leading factors. Am J Respir Crit Care Med 189(10):1194–1203

    Article  PubMed  Google Scholar 

  107. Rasmussen F, Lambrechtsen J, Siersted HC, Hansen HS, Hansen NC (2000) Low physical fitness in childhood is associated with the development of asthma in young adulthood: the Odense schoolchild study. Eur Respir J 16(5):866–870

    Article  CAS  PubMed  Google Scholar 

  108. Almqvist C, Pershagen G, Wickman M (2005) Low socioeconomic status as a risk factor for asthma, rhinitis and sensitization at 4 years in a birth cohort. Clin Exp Allergy 35(5):612–618

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Respiratory, Critical Care and Anaesthesia Section, University College London, Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK

    Katharine C. Pike

  2. Department of Pediatrics, Divisions of Respiratory Medicine and Neonatology, University Medical Center Rotterdam, Erasmus MC—Sophia Children’s Hospital, 2060, 3000 CB, Rotterdam, The Netherlands

    Liesbeth Duijts

Authors
  1. Katharine C. Pike
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  2. Liesbeth Duijts
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Correspondence to Katharine C. Pike .

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Editors and Affiliations

  1. Institute of Developmental Sciences, University of Southampton, Southampton, Hampshire, United Kingdom

    Lucy R. Green

  2. Medical Center, The University of Mississippi, Jackson, Mississippi, USA

    Robert L. Hester

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Pike, K.C., Duijts, L. (2016). Maternal Obesity Effects on the Risk of Allergic Diseases in Offspring. In: Green, L., Hester, R. (eds) Parental Obesity: Intergenerational Programming and Consequences. Physiology in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6386-7_15

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