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DDRs: Binding Properties, Cell Adhesion and Modulation of Integrin Function

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Discoidin Domain Receptors in Health and Disease

Abstract

The discoidin domain receptors are a subfamily of receptor tyrosine kinases that consist of two members, DDR1 and DDR2. These closely related proteins are characterized by the presence of a discoidin homology (DS) domain in their extracellular regions, as well as a domain of similar structure, the DS-like domain. The DDRs function as transmembrane collagen receptors and are thus at the interface of receptor tyrosine kinases and integrins, the main receptors for extracellular matrix molecules. Both DDRs are activated by a number of different collagen types, with which they interact through a conserved ligand-binding trench that is contained in their DS domains. The DDRs have overlapping functions with integrins and can modulate cell adhesion and cell migration. Depending on the cellular context, DDR-induced signalling can impact integrin-mediated signalling in positive or negative ways. Here, the DDRs are discussed in terms of their molecular basis of collagen recognition, their roles in cell adhesion and migration and their ability to modulate integrin function.

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  1. Molecular Medicine Section, NHLI, Imperial College London, London, UK

    Birgit Leitinger

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  1. Department of Pathology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan, USA

    Rafael Fridman

  2. Division of Cancer Biology, The Institute of Cancer Research, London, United Kingdom

    Paul H. Huang

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Leitinger, B. (2016). DDRs: Binding Properties, Cell Adhesion and Modulation of Integrin Function. In: Fridman, R., Huang, P. (eds) Discoidin Domain Receptors in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6383-6_1

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