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Deiodinase and Brain Development

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Thyroid Hormone Disruption and Neurodevelopment

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

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Abstract

Thyroid hormone receptors are enriched in neurons which are the primary target of T3 actions. Type 2 iodothyronine deiodinase (D2), which catalyzes conversion of thyroxine (T4) to 3,5,3′-triiodothyronine (T3), is expressed predominantly in glial cells, and type 3 iodothyronine deiodinase (D3), which catalyzes conversion of T4 to 3,3′,5′-triiodothyronine (rT3) and T3 to 3,3′-diiodothyronine (T2), is expressed in neurons. Thyroid hormone metabolism by D2 and D3 plays important roles in brain function and development.

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Authors and Affiliations

  1. Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, 371-8511, Japan

    Masami Murakami

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  1. Masami Murakami
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Correspondence to Masami Murakami .

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Editors and Affiliations

  1. Department of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Noriyuki Koibuchi

  2. Laboratory of Hormonal Regulation Cardiovascular and Metabolic Disorders Program, Duke-NUS Graduate Medical School, Singapore, Singapore

    Paul M. Yen

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Murakami, M. (2016). Deiodinase and Brain Development. In: Koibuchi, N., Yen, P.M. (eds) Thyroid Hormone Disruption and Neurodevelopment. Contemporary Clinical Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3737-0_2

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