Abstract
Noninvasive molecular imaging, using positron emission tomography (PET), is an important technique to visualize metabolic processes in vivo. It also allows to visualize the process of apoptosis, by using radiolabeled compounds such as Annexin V, that bind to extracellular phosphatidylserine (PS). This chapter describes the radiosynthesis of 68Ga-labeled Annexin V and how to noninvasively image apoptosis in vivo.
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Acknowledgements
This work was financially supported by the European Union through the grant Euregional PACT II by the Interreg IV program of Grensregio Vlaanderen-Nederland (IVA-VLANED-1.20) and the Center of Excellence “MoSAIC” of the K.U. Leuven.
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Bauwens, M. (2016). In Vivo Apoptosis Imaging Using Site-Specifically 68Ga-Labeled Annexin V. In: Puthalakath, H., Hawkins, C. (eds) Programmed Cell Death. Methods in Molecular Biology, vol 1419. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3581-9_2
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DOI: https://doi.org/10.1007/978-1-4939-3581-9_2
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