Abstract
The importance of understanding mechanisms of blood–material interactions is emphasized by the increasingly widespread use of cardiovascular devices; hence, this field has been the subject of intense inquiry as described in several excellent reviews [1–4]. Unfortunately, it is still not possible to simply rank or classify materials with respect to their suitability for particular blood-contacting applications. Nor is it possible to predict in any general way, based on the properties of devices and of their blood-contacting surfaces, the behavior of blood in contact with materials or the propensity of devices to produce clinically adverse events. Despite many attempts to correlate biologic responses to physicochemical property measurements, our success in understanding blood–material interactions, and the clinical application of many blood-contacting devices, has been largely empirical. It is not appropriate to discuss in detail this large and controversial literature, which has been reviewed elsewhere [1, 2]. Rather, this section will focus on the available experimental data in humans, or results which may likely be extrapolated to humans from relevant animal studies, that may guide in the development of new designs for blood-contacting devices. Cardiovascular device applications in humans have also been the subject of an excellent review [5].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Salzman, E.W., Merrill, E.W. and Kent K.C. (1994) Interaction of blood with artificial surfaces, in Hemostasis and Thrombosis: Basic Principles and Clinical Practice, 3rd edn, R.W. Colman, J. Hirsch, V.J. Marder, and Salzman, E.W. (eds), J.B. Lippincott, Philadelphia, pp. 1469–85.
Harker, L.A., Ratner, B.D. and Didisheim, P. (eds) (1993) Cardiovascular Biomaterials and Biocompatibility, Cardiovascular Pathology 2(3)(supplement), 1S–224S.
Szycher, M. (ed.) (1983) Biocompatible Polymers, Metals, and Composites, Technomic Publishing Co., Lancaster, Pennsylvania.
Williams, D.F. (ed) (1981) Biocompatibility of Clinical Implant Materials, CRC Press, Boca Raton, Florida.
Clagett, G.P. and Eberhart, R.C. (1994) Artificial Devices in Clinical Practice, in Hemostasis and Thrombosis: Basic Principles and Clinical Practice, 3rd edn R.W. Colman, J. Hirsch, V.J. Marder, and Salzman, E.W. (eds), J.B. Lippincott, Philadelphia, pp. 1486–1505.
Grabowski, E.F., Didisheim, P., Lewis, J.C. et al. (1977) Platelet adhesion to foreign surfaces under controlled conditions of whole blood flow: human vs. rabbit, dog, calf, sheep, pig, macaque, and baboon. Transactions - American Society for Artificial Internal Organs, 23, 141–51.
Lentner, C. (ed.) (1984) Geigy Scientific Tables (vol. 3): Physical Chemistry, Composition of blood, Hematology, Somatometric Data, Ciby-Geigy, Basle.
Brash, J.L. and Horbett, T.A. (eds) (1987) Proteins at Interfaces. Physicochemical and Biochemical Studies, American Chemical Society, Washington, DC.
Harker, L.A. and Slichter, S.J. (1972) Platelet and fibrinogen consumption in man. New England J Med. 287(20), 999–1005.
Bennett, B., Booth, N.A., Ogston D. (1987) Potential interactions between complement, coagulation, fibrinolysis, kinin-forming, and other enzyme systems, in: Haemostasis and Thrombosis (2nd edn), A.L. bloom and D.P. Thomas (eds), Churchill Livingstone, New York, pp. 267–82.
Andrew, M. (1995) Developmental hemostasis: relevance to thromboembolic complications in pediatric patients. Thrombosis and Hemostasis, 74(1), 415–25.
Hanson, S.R., Harker, L.S., Ratner, B.D. et al. (1980) In vivo evaluation of artificial surfaces using a nonhuman primate model of arterial thrombosis. J Laboratory Clinical Med. 95, 289–304.
Silver, J.H., Myers, C.W., Lim, F. et al. (1994) Effect of polyol molecular weight on the physical properties and haemocompatibility of polyurethanes containing polyethylene oxide macroglycols. Biomaterials 15(9), 695–704.
Hoffman, A.S. (1974) Principles governing biomolecular interactions at foreign surfaces. J. Biomedical Materials Res. (Symp.) 5(1), 77–83.
Andrade, J.D., Lee, H.B., Jhon, M.S. et al. (1973) Water as a biomaterial. Transactions- American Society for Artificial Internal Organs 19, 1–7.
Strzinar, I. and Sefton, M.V. (1992) Preparation and thrombogenicity of alkylated polyvinyl alcohol coated tubing. J. Biomedical Materials Research 26, 577–92.
Merrill, E.W. (1993) Poly(ethylene oxide) star molecules: synthesis, characterization, and applications in medicine and biology. J. Biomaterials Science, Polymer Edition 5(1–2), 1–11.
Llanos, G.R. and Sefton, M.V. (1993) Does polyethylene oxide possess a low thrombogenicity? J. Biomaterials Science, Polymer Edition, 4(4), 381–400.
Sigwart, U., Puel, J., Mirkovitch, V. et al. (1987) Intravascular stents to prevent occlusion and restenosis after transluminal angioplasty. New England J. Med, 316(12), 701–6.
Scott, N.A., Nunes, G.L., King, S.B. et al. (1995) A comparison of the thrombogenicity of stainless steel and tantalum coronary stents. American Heart J., 129, 866–72.
Saywer, P.N., Stanczewski, B., Lucas, T.R., et al. (1978) Physical chemistry of the vascular interface, in Vascular Grafts, P.N. Sawyer and M.J. Kaplitt (eds), Appleton -Century-Crofts, New York, pp. 53–75.
Rapold, H.J., Stassen, T., Van de Werf, F., et al. (1992) Comparative copper coil-induced thrombogenicity of the internal mammary, left anterior descending coronary, and popliteal arteries in dogs. Arteriosclerosis and Thrombosis, 12(5), 634–44.
Schoen, F.J. (1983) Carbons in heart valve prostheses: Foundations and clinical performance, in M. Szycher (ed.), Biocompatible Polymers, Metals, and Composites, Technomic Publishing Co., Lancaster, Pennsylvania, pp. 239–61.
Yasuda, H.K. (1985) Plasma Polymerization, Academic Press, Orlando.
Yeh, Y.S., Iriyama, T., Matsuzawa, Y., et al. (1988) blood compatibility of surfaces modified by plasma polymerization. J. Biomedical Materials Research, 22, 795–818.
Harker, L.A., Malpass, T.W., Branson H.E., et al. (1980) Mechanism of abnormal bleeding in patients undergoing cardiopulmonary bypass: acquired transient platelet dysfunction associated with selective alpha-granule release. blood, 56(5), 824–34.
Hakim, R. (1993) Complement activation by biomaterials. Cardiovascular Pathology, 2(3)(suppl), 187S-198S.
Yu, J., Lamba, N.M., Courtney J.M., et al. (1994) Polymeric biomaterials: Influence of phosphorylcholine polar groups on protein adsorption and complement activation. International Journal of Artificial Organs, 17(9), 499–504.
Hardhammer, P.A., van Beusekom H.M., Emanuelsson, H.U., et al. (1996) Reduction in thrombotic events with heparin-coated Palmaz-Schatz stents in normal porcine coronary arteries. Circulation, 93(3), 423–30.
Schneider, P.A., Kotze, H.F., Heyns, A. duP., et al. (1989) Thromboembolic potential of synthetic vascular grafts in baboons. J. Vascular Surgery, 10, 75–82.
Dasse, K.A., Poirier, V.L., Menconi, M.J., et al. (1990) Characterization of TCPS textured blood-contacting materials following long-term clinical LVAD support. In: Cardiovascular Science and Technology: Basic and Applied: II, JC Norman (ed.), Oxymoron Press, Boston, MA, pp. 218–220.
Kormos, R.L., Armitage, J.M., Borovetz, H.S., et al. (1990) Univentricular support with the Novocor left ventricular assist system as a bridge to cardiac transplantation: An update in Cardiovascular Science and Technology: Basic and Applied: II, JC Norman (Ed), Oxymoron Press, Boston, MA, pp. 322–324.
Acknowledgement
This work was supported by Research Grant HL 31469 from the Heart, Lung and blood Institute, the National Institutes of Health.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Additional Reading
Additional Reading
Colman, R.W., Hirsch, J., Marder, V.J. and Salzman, E.W. (eds)(1994) Hemostasis and Thrombosis: Basic Principles and Clinical Practice, 3rd edn, J.B. Lippincott, Philadelphia.
This book is highly recommended. This state-of-the-art text covers in detail essentially all important hematological aspects of cardiovascular device blood compatibility. In particular, Chapter 76, Interaction of blood with artificial surfaces, which considers many theoretical, experimental, and animal studies, and Chapter 77, Artificial devices in clinical practice, which describes clinical device thromboembolic complications, are of great practical value.
Harker, L.A., Ratner, B.D. and Didisheim, P. (eds)(1993) Cardiovascular Biomaterials and Biocompatibility, Cardiovascular Pathology, 2(3) (suppl.), 1S–224S.
In this volume, 20 chapters by expert authors treat all aspects of biomaterials and blood compatibility including pathologic mechanisms, material characterization, blood-material interactions and device performance. This volume updates an excellent earlier book Guidelines for blood-Material Interactions, National Institutes of Health, Washington, DC, Publication No. 85–2185 (1985).
Szycher, M. (ed.) (1983) Biocompatible Polymers, Metals, and Composites, Technomic Publishing Co., Lancaster, Pennsylvania.
Many of the same issues of blood–material interactions are broadly covered while selected polymer and device applications are described in additional detail. of particular interest are Section I (Fundamental Concepts in blood/Material Interactions) and Section II (Strategies for Hemocompatibility).
Rights and permissions
Copyright information
© 2016 Springer Science+Business Media New York
About this chapter
Cite this chapter
Hanson, S.R. (2016). Chapter 6 Blood–material Interactions. In: Murphy, W., Black, J., Hastings, G. (eds) Handbook of Biomaterial Properties. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3305-1_33
Download citation
DOI: https://doi.org/10.1007/978-1-4939-3305-1_33
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4939-3303-7
Online ISBN: 978-1-4939-3305-1
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)