Abstract
In this study we investigated the effect of aging on brain blood flow following transient global ischemia. Male Fisher rats (6 and 24 months old) underwent cardiac arrest (15 min) and resuscitation. Regional brain (cortex, hippocampus, brainstem and cerebellum) blood flow was measured in non-arrested rats and 1-h recovery rats using [14C] iodoantipyrene (IAP) autoradiography; the 4-day survival rate was determined in the two age groups. The pre-arrest baseline blood flows were similar in cortex, brainstem and cerebellum between the 6-month and the 24-month old rats; however, the baseline blood flow in hippocampus was significantly lower in the 24-month old group. At 1 h following cardiac arrest and resuscitation, both 6-month and 24-month groups had significantly lower blood flows in all regions than the pre-arrest baseline values; compared to the 6-month old group, the blood flow was significantly lower (about 40 % lower) in all regions in the 24-month old group. The 4-day survival rate for the 6-month old rats was 50 % (3/6) whereas none of the 24-month old rats (0/10) survived for 4 days. The data suggest that there is an increased vulnerability to brain ischemic-reperfusion injury in the aged rats; the degree of post-recovery hypoperfusion may contribute to the high mortality in the aged rats following cardiac arrest and resuscitation.
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References
Zheng ZJ, Croft JB, Giles WH et al (2001) Sudden cardiac death in the United States, 1989 to 1998. Circulation 104:2158–2163
Gidday JM, Kim YB, Shah AR et al (1996) Adenosine transport inhibition ameliorates postischemic hypoperfusion in pigs. Brain Res 734:261–268
Adrie C, Adib-Conquy M, Laurent I et al (2002) Successful cardiopulmonary resuscitation after cardiac arrest as a “sepsis-like” syndrome. Circulation 106:562–568
Xu K, Puchowicz MA, Lust WD et al (2006) Adenosine treatment delays postischemic hippocampal CA1 loss after cardiac arrest and resuscitation in rats. Brain Res 1071:208–217
Xu K, Puchowicz MA, Sun X et al (2010) Decreased brainstem function following cardiac arrest and resuscitation in aged rat. Brain Res 1328:181–189
Xu K, LaManna JC (2009) The loss of hypoxic ventilatory responses following resuscitation after cardiac arrest in rats is associated with failure of long-term survival. Brain Res 1258:59–64
Palkovits M, Brownstein MJ (1988) Maps and guide to microdissection of rat brain. Elsevier, New York
Negovsky VA, Gurvitch AM (1995) Post-resuscitation disease--a new nosological entity. Its reality and significance. Resuscitation 30:23–27
Mortberg E, Cumming P, Wiklund L et al (2009) Cerebral metabolic rate of oxygen (CMRO2) in pig brain determined by PET after resuscitation from cardiac arrest. Resuscitation 80:701–706
Oku K, Kuboyama K, Safar P et al (1994) Cerebral and systemic arteriovenous oxygen monitoring after cardiac arrest. Inadequate cerebral oxygen delivery. Resuscitation 27:141–152
Sterz F, Leonov Y, Safar P et al (1992) Multifocal cerebral blood flow by Xe-CT and global cerebral metabolism after prolonged cardiac arrest in dogs. Reperfusion with open-chest CPR or cardiopulmonary bypass. Resuscitation 24:27–47
Aanerud J, Borghammer P, Chakravarty MM et al (2012) Brain energy metabolism and blood flow differences in healthy aging. J Cereb Blood Flow Metab 32:1177–1187
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This study was supported by NIH grant NINDS 1 R01 NS46074.
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Xu, K., Puchowicz, M.A., LaManna, J.C. (2016). Aging Effect on Post-recovery Hypofusion and Mortality Following Cardiac Arrest and Resuscitation in Rats. In: Elwell, C.E., Leung, T.S., Harrison, D.K. (eds) Oxygen Transport to Tissue XXXVII. Advances in Experimental Medicine and Biology, vol 876. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3023-4_33
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DOI: https://doi.org/10.1007/978-1-4939-3023-4_33
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