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Health Economics in Clinical Research

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Clinical Epidemiology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1281))

Abstract

The pressure for health care systems to provide more resource intensive health care and newer, more costly, therapies is significant, despite limited health care budgets. As such, demonstration that a new therapy is effective is no longer sufficient to ensure that it is funded within publicly funded health care systems. The impact of a therapy on health care costs is also an important consideration for decision-makers who must allocate scarce resources. The clinical benefits and costs of a new therapy can be estimated simultaneously using economic evaluation, the strengths and limitations of which are discussed herein. In addition, this chapter includes discussion of the important economic outcomes that can be collected within a clinical trial (alongside the clinical outcome data) enabling consideration of the impact of the therapy on overall resource use, thus enabling performance of an economic evaluation, if the therapy is shown to be effective.

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References

  1. Manns B, Taub K, Donaldson C (2000) Economic evaluation and end-stage renal disease: from basics to bedside. Am J Kidney Dis 36:12–28

    Article  CAS  PubMed  Google Scholar 

  2. U.S. Renal Data System, USRDS (2013) Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD

    Google Scholar 

  3. Hirth RA (2007) The organization and financing of kidney dialysis and transplant care in the United States of America. Int J Health Care Finance Econ 7(4):301–318

    Article  PubMed  Google Scholar 

  4. Tomson CR (2000) Recent advances: nephrology. BMJ 320(7227):98–101

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  5. Manns BJ, Mendelssohn DC, Taub KJ (2007) The economics of end-stage renal disease care in Canada: incentives and impact on delivery of care. Int J Health Care Finance Econ 7(2–3):149–169

    Article  PubMed  Google Scholar 

  6. Donaldson C, Shackley P, Detels R, Holland WW, McEwan J, Omenn GS (1997) Economic evaluation. Oxford textbook of public health. (3 edn). Oxford: Oxford University Press, pp 849–870

    Google Scholar 

  7. Manns B, Doig CJ, Lee H, Dean S, Tonelli M, Johnson D, Donaldson C (2003) Cost of acute renal failure requiring dialysis in the intensive care unit: clinical and resource implications of renal recovery. Crit Care Med 31(2):449–455

    Article  PubMed  Google Scholar 

  8. Johannesson M, Jonsson B, Kjekshus J, Olsson AG, Pedersen TR, Wedel H (1997) Cost effectiveness of simvastatin treatment to lower cholesterol levels in patients with coronary heart disease. Scandinavian Simvastatin Survival Study Group. N Engl J Med 336(5):332–336

    Article  CAS  PubMed  Google Scholar 

  9. Lee H, Manns B, Taub K, Ghali WA, Dean S, Johnson D, Donaldson C (2002) Cost analysis of ongoing care of patients with end-stage renal disease: the impact of dialysis modality and dialysis access. Am J Kidney Dis 40(3):611–622

    Article  PubMed  Google Scholar 

  10. Klarenbach S, Tonelli M, Pauly R, Walsh M, Culleton B, So H, Hemmelgarn B, Manns B (2014) Economic evaluation of frequent home nocturnal hemodialysis based on a randomized controlled trial. J Am Soc Nephrol 25(3):587–594

    Article  PubMed  Google Scholar 

  11. Chui BK, Manns B, Pannu N, Dong J, Wiebe N, Jindal K, Klarenbach SW (2013) Health care costs of peritoneal dialysis technique failure and dialysis modality switching. Am J Kidney Dis 61(1):104–111

    Article  PubMed  Google Scholar 

  12. Fenton SS, Schaubel DE, Desmeules M, Morrison HI, Mao Y, Copleston P, Jeffery JR, Kjellstrand CM (1997) Hemodialysis versus peritoneal dialysis: a comparison of adjusted mortality rates. Am J Kidney Dis 30(3):334–342

    Article  CAS  PubMed  Google Scholar 

  13. Foley RN, Parfrey PS, Harnett JD, Kent GM, O'Dea R, Murray DC, Barre PE (1998) Mode of dialysis therapy and mortality in end-stage renal disease. J Am Soc Nephrol 9(2):267–276

    CAS  PubMed  Google Scholar 

  14. Bloembergen WE, Port FK, Mauger EA, Wolfe RA (1995) A comparison of mortality between patients treated with hemodialysis and peritoneal dialysis. J Am Soc Nephrol 6(2):177–183

    CAS  PubMed  Google Scholar 

  15. Collins AJ, Hao W, Xia H, Ebben JP, Everson SE, Constantini EG, Ma JZ (1999) Mortality risks of peritoneal dialysis and hemodialysis. Am J Kidney Dis 34(6):1065–1174

    Article  CAS  PubMed  Google Scholar 

  16. Gerard K, Mooney G (1993) QALY league tables: handle with care. Health Econ 2(1):59–64

    Article  CAS  PubMed  Google Scholar 

  17. Mauskopf J, Rutten F, Schonfeld W (2003) Cost-effectiveness league tables: valuable guidance for decision makers? Pharmacoeconomics 21(14):991–1000

    Article  PubMed  Google Scholar 

  18. Drummond M, O’Brien B, Stoddart G, Torrance G (1997) Methods for the economic evaluation of health care programmes, 2nd edn. Oxford University Press, Oxford

    Google Scholar 

  19. Cameron C, Coyle D, Ur E, Klarenbach S (2010) Cost-effectiveness of self-monitoring of blood glucose in patients with type 2 diabetes mellitus managed without insulin. Can Med Assoc J 182(1):28–34

    Article  Google Scholar 

  20. McIntosh B, Yu C, Lal A, Chelak K, Cameron C, Singh SR, Dahl M (2010) Efficacy of self-monitoring of blood glucose in patients with type 2 diabetes mellitus managed without insulin: a systematic review and meta-analysis. Open Med 4(2):e102–e113

    PubMed Central  PubMed  Google Scholar 

  21. Guideliness for the economic evaluation of health technologies: Canada [3rd edition]. Ottawa: Canadian Agency for Drugs and Technologies in Health; 2006

    Google Scholar 

  22. McGhan WF, Al M, Doshi JA, Kamae I, Marx SE, Rindress D (2009) The ISPOR good practices for quality improvement of cost-effectiveness research task force report. Value Health 12(8):1086–1099

    Article  PubMed  Google Scholar 

  23. Drummond MF, Jefferson TO (1996) Guidelines for authors and peer reviewers of economic submissions to the BMJ. The BMJ Economic Evaluation Working Party. BMJ 313(7052):275–283

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  24. Gold R, Siegel J, Russell L, Weinstein M (1996) Cost-effectiveness in health and medicine. Oxford University Press, New York

    Google Scholar 

  25. Donaldson C, Currie G, Mitton C (2002) Cost effectiveness analysis in health care: contraindications. BMJ 325(7369):891–894

    Article  PubMed Central  PubMed  Google Scholar 

  26. Laupacis A, Feeny D, Detsky AS, Tugwell PX (1992) How attractive does a new technology have to be to warrant adoption and utilization? Tentative guidelines for using clinical and economic evaluations. CMAJ 146(4):473–481

    PubMed Central  CAS  PubMed  Google Scholar 

  27. Schwappach DL (2003) Does it matter who you are or what you gain? An experimental study of preferences for resource allocation. Health Econ 12(4):255–267

    Article  PubMed  Google Scholar 

  28. Shrive FM, Ghali WA, Lewis S, Donaldson C, Knudtson ML, Manns BJ (2005) Moving beyond the cost per quality-adjusted life year: modeling the budgetary impact and clinical outcomes associated with the use of sirolimus-eluting stents. Can J Cardiol 21(9):783–787

    PubMed  Google Scholar 

  29. Clement FM, Harris A, Li JJ, Yong K, Lee KM, Manns BJ (2009) Using effectiveness and cost-effectiveness to make drug coverage decisions: a comparison of Britain, Australia, and Canada. JAMA 302(13):1437–1443

    Article  CAS  PubMed  Google Scholar 

  30. Miners AH, Garau M, Fidan D, Fischer AJ (2005) Comparing estimates of cost effectiveness submitted to the National Institute for Clinical Excellence (NICE) by different organisations: retrospective study. BMJ 330(7482):65

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  31. O'Brien B (1996) Economic evaluation of pharmaceuticals. Frankenstein’s monster or vampire of trials? Med Care 34(12 Suppl):DS99–DS108

    PubMed  Google Scholar 

  32. Ramsey SD, Berry K, Etzioni R, Kaplan RM, Sullivan SD, Wood DE (2003) Cost effectiveness of lung-volume-reduction surgery for patients with severe emphysema. N Engl J Med 348(21):2092–2102

    Article  PubMed  Google Scholar 

  33. Tonelli M, Klaarenbach S, Jindal K, Manns B (2006) Economic implications of screening strategies in arteriovenous fistulae. Kidney Int 69(12):2219–2226

    Article  CAS  PubMed  Google Scholar 

  34. Stelfox HT, Hemmelgarn BR, Bagshaw SM, Gao S, Doig CJ, Nijssen-Jordan C, Manns B (2012) Intensive care unit bed availability and outcomes for hospitalized patients with sudden clinical deterioration. Arch Intern Med 172(6):467–474

    Article  PubMed  Google Scholar 

  35. Manns B, Owen WF Jr, Winkelmayer WC, Devereaux PJ, Tonelli M (2006) Surrogate markers in clinical studies: problems solved or created? Am J Kidney Dis 48(1):159–166

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. University of Calgary, 1403, 29th Street NW, Calgary, AB, Canada, T2N 2T9

    Braden J. Manns

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  1. Braden J. Manns
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Corresponding author

Correspondence to Braden J. Manns .

Editor information

Editors and Affiliations

  1. Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada

    Patrick S. Parfrey

  2. Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada

    Brendan J. Barrett

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© 2015 Springer Science+Business Media New York

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Manns, B.J. (2015). Health Economics in Clinical Research. In: Parfrey, P., Barrett, B. (eds) Clinical Epidemiology. Methods in Molecular Biology, vol 1281. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2428-8_19

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  • DOI: https://doi.org/10.1007/978-1-4939-2428-8_19

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-2427-1

  • Online ISBN: 978-1-4939-2428-8

  • eBook Packages: Springer Protocols

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