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Respiratory Syncytial Virus

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Global Virology I - Identifying and Investigating Viral Diseases

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Abstract

Development of a safe, effective, and inexpensive prophylactic for respiratory syncytial virus has been a long-sought goal that may finally be within reach. Decades of research into the molecular biology of virus-host interactions and the consequent cellular immune responses has provided several potential targets for antiviral intervention. Knowledge of RSV biology and the complex cascade of events the innate and adaptive immune systems perform in the body’s attempt to clear the viral invaders have shown us its weak points where we may be able to block infection. Like a true predator, however, RSV targets the very young and the very old and this fact makes the job of prevention more difficult and challenging. The immature infant immune system and the aged immune system are very different and require unique approaches for prophylaxis and therapy for respiratory infections. The interdisciplinary attack by bioengineers, molecular biologists, clinical researchers, drug discovery experts, and others has produced many possible weapons and it is hoped that globally applicable controls of RSV may soon be added to the clinician’s arsenal.

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Acknowledgements

This work was supported in part by a Research Career Scientist Award and VA Merit Review Award 5I01BX000954-02 by the Department of Veteran Affairs and NIH grant 1P30HL101265-01 to S.S. Mohapatra at the James A Haley VA Hospital and the University of South Florida. Although this review is based upon work supported in part by Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, the contents of this report do not represent the views of the Department of Veterans Affairs or the US Government.

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Authors and Affiliations

  1. James A. Haley VA Medical Center, 13000 Bruce B Downs Blvd, Tampa, FL, USA

    Gary Hellermann & Shyam Mohapatra

  2. Division of Translational Medicine and Nanomedicine Research Center, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA

    Gary Hellermann & Shyam Mohapatra

  3. Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA

    Gary Hellermann & Shyam Mohapatra

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  1. Gary Hellermann
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Correspondence to Shyam Mohapatra .

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Editors and Affiliations

  1. Division of Infectious Diseases and International Medicine, USF Morsani College of Medicine, Tampa, Florida, USA

    Paul Shapshak

  2. Infectious Diseases and International He, USF Morsani College of Medicine, Tampa, Florida, USA

    John T. Sinnott

  3. Division of Infectious Diseases and Inte, USF Morsani College of Medicine, Tampa, Florida, USA

    Charurut Somboonwit

  4. C.W. Bill Young Center for Biodefense & Emerging Infectious Diseases, NIH-NIAID Div. Clinical Research, Frederick, Maryland, USA

    Jens H. Kuhn

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Hellermann, G., Mohapatra, S. (2015). Respiratory Syncytial Virus. In: Shapshak, P., Sinnott, J., Somboonwit, C., Kuhn, J. (eds) Global Virology I - Identifying and Investigating Viral Diseases. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2410-3_5

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