Skip to main content
SpringerLink
Log in

Congenital Hemihyperplasia

  • Reference work entry
  • First Online:
Atlas of Genetic Diagnosis and Counseling

  • 181 Accesses

Abstract

In 1822, Meckel (1822) first described congenital hemihypertrophy. Hemihypertrophy, also called hemihyperplasia, is defined as asymmetric body overgrowth of one or more body parts. The overgrowth may involve an entire half of the body, a single limb, and one side of the face or combinations thereof. There may be accompanying asymmetric visceromegaly. Hemihyperplasia can be isolated or can occur as part of a syndrome. It is frequently not possible to determine if the enlargement is due to an increase in the size of cells (hypertrophy) or to an increase in the number of cells of normal size (hyperplasia) (Ballock et al. 1997).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Ballock, R. T., Wiesner, G. L., Myers, M. T., et al. (1997). Hemihypertrophy. Concepts and controversies. Journal of Bone and Joint Surgery. American Volume, 79, 1731–1738.

    Article  CAS  Google Scholar 

  • Bliek, J., Maas, S., Alders, M., et al. (2008). Epigenotype, phenotype, and tumors in patients with isolated hemihyperplasia. Journal of Pediatrics, 153, 95–100.

    Article  CAS  PubMed  Google Scholar 

  • Boybeyi, Ö., Alanay, Y., & Kayıkçıoğlu, A. (2010). Hemihyperplasia-multiple lipomatosis syndrome: An underdiagnosed entity in children with asymmetric overgrowth. Journal of Pediatric Surgery, 45, E19–E23.

    Article  PubMed  Google Scholar 

  • Burchfield, D., & Escobar, V. (1980). Familial facial asymmetry (autosomal dominant hemihypertrophy?). Oral Surgery, Oral Medicine, and Oral Pathology, 50, 321–324.

    Article  CAS  PubMed  Google Scholar 

  • Clericuzio, C. L., & Martin, R. A. (2009). Diagnostic criteria and tumor screening for individuals with isolated hemihyperplasia. Genetics in Medicine, 11, 220–222.

    Article  PubMed  PubMed Central  Google Scholar 

  • Cohen, M. M. Jr. (1989). A comprehensive and critical assessment of overgrowth and overgrowth syndromes. Advances in Human Genetics, 18, 181–303.

    Article  PubMed  Google Scholar 

  • Craiglow, B. G., Ko, C. J., & Antaya, R. J. (2014). Two cases of hemihyperplasia-multiple lipomatosis syndrome and review of asymmetric hemihyperplasia syndromes. Pediatric Dermatology, 31, 507–510.

    Article  PubMed  Google Scholar 

  • Furukawa, T., & Shinohara, T. (1981). Congenital hemihypertrophy: Oncogenic potential of the hypertrophic side. Annals of Neurology, 10, 199–201.

    Article  CAS  PubMed  Google Scholar 

  • Geormaneanu, M., Iagaru, N., Popescu-Miclosanu, S., et al. (1983). Congenital hemihypertrophy. Tendency to association with other abnormalities and/or tumors. Morphology and Embryology, 29, 39–45.

    CAS  PubMed  Google Scholar 

  • Heilstedt, H. A., & Bacino, C. A. (2004). A case of familial isolated hemihyperplasia. BMC Medical Genetics, 2004, 1–6.

    Article  Google Scholar 

  • Hoyme, H. E., Seaver, L. H., Jones, K. L., et al. (1998). Isolated hemihyperplasia (hemihypertrophy): Report of a prospective multicenter study of the incidence of neoplasia and review. American Journal of Medical Genetics, 79, 274–278.

    Article  CAS  PubMed  Google Scholar 

  • Keppler-Noreuil, K. M., Rios, J. J., Parker, V. E. R., et al. (2015). PIK3CA-related overgrowth spectrum (PROS): Diagnostic and testing eligibility criteria, differential diagnosis, and evaluation. American Journal of Medical Genetics Part A, 167A, 287–295.

    Article  PubMed  Google Scholar 

  • Lee, M. S., Liang, M. G., & Milliken, J. B. (2013). Diffuse capillary malformation with overgrowth: a clinical subtype of vascular anomalies with hypertrophy. Journal of American Academy of Dermatology, 69, 589–594.

    Article  Google Scholar 

  • Lee, M. S., Liang, M. G., & Milliken, J. B. (2013). Diffuse capillary malformation with overgrowth: a clinical subtype of vascular anomalies with hypertrophy. Journal of American Academy of Dermatology, 69, 589–594.

    Article  Google Scholar 

  • Martin, R. A., Grange, D. K., Zehnbauer, B., et al. (2005). LIT1 and H19 methylation defects in isolated hemihyperplasia. American Journal of Medical Genetics, 134A, 129–131.

    Article  PubMed  Google Scholar 

  • Meckel, J. (1822). Über die seitliche: Asymmetrie im tierischen Korper. In Anatomische physiologisches Beobachtungen und Untersuchungen (p. 147). Halle: Renger.

    Google Scholar 

  • Shuman, C., Smith, A. c., Steele, L., et al. (2006). Constitutional UPD for chromosome 11p15 in individuals with isolated hemihyperplasia is associated with high tumor risk and occurs following assisted reproductive technologies. American Journal of Medical Genetics Part A, 140A, 1497–1503.

    Article  CAS  Google Scholar 

  • Stoll, C., Alembik, Y., Steib, J. P., et al. (1993). Twelve cases with hemihypertrophy: Etiology and follow up. Genetic Counseling, 4, 119–126.

    CAS  PubMed  Google Scholar 

  • Viljoen, D., Pearn, J., & Beighton, P. (1984). Manifestations and natural history of idiopathic hemihypertrophy: A review of eleven cases. Clinical Genetics, 26, 81–86.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medical Genetics, Shriners Hospitals for Children, Perinatal and Clinical Genetics, Department of Pediatrics, LSU Health Sciences Center, Shreveport, LA, USA

    Harold Chen

Authors
  1. Harold Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer Science+Business Media LLC

About this entry

Cite this entry

Chen, H. (2017). Congenital Hemihyperplasia. In: Atlas of Genetic Diagnosis and Counseling. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2401-1_52

Download citation

  • DOI: https://doi.org/10.1007/978-1-4939-2401-1_52

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-2400-4

  • Online ISBN: 978-1-4939-2401-1

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation