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Finding Endophenotypes for Autism Spectrum Disorders (ASD): cDNA Microarrays and Brain Transcripts

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Organism Models of Autism Spectrum Disorders

Part of the book series: Neuromethods ((NM,volume 100))

Abstract

cDNA microarrays are also known as “DNA chips,” “microarrays,” or “biochips.” They carry several thousands of probes covering the whole genome. The cDNA microarray strategy offers an opportunity to obtain an overall picture of a gene transcript profile in a given tissue and even in a single cell. The chapter presents the molecular rationale of the technique and indicates the most salient pitfalls encountered during the analysis of the data. Preliminary data have been obtained by analyzing postmortem brain samples of persons who were diagnosed as affected by ASD. These results are promising since they indicate a correspondence between the dimensions of psychiatric inventories and gene profiling. We consider here the possibility to use the conclusions of gene profiling in ASD patients to model autism in nonhuman organisms.

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Author information

Authors and Affiliations

  1. INSERM, GMGF UMR_S 910, Aix Marseille Université, Marseille, France

    Patrice Bourgeois & Pierre L. Roubertoux

  2. INSERM, UMR_S 910, Génétique Médicale, Génomique Fonctionnelle, INSERM UMR_S 910, 27 Boulevard Jean Moulin, 13385, Marseille, France

    Patrice Bourgeois & Pierre L. Roubertoux

  3. AP-HM, Département de Génétique Médicale, Hôpital d’enfants Timone, Marseille, France

    Patrice Bourgeois

Authors
  1. Patrice Bourgeois
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  2. Pierre L. Roubertoux
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Corresponding author

Correspondence to Patrice Bourgeois .

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Editors and Affiliations

  1. Inserm GMGF UMR_S 910, Génomique Fonctionnelle INSERM UMR_S 910, Aix Marseille Université, Génétique Médicale, Marseille, France

    Pierre L. Roubertoux

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Bourgeois, P., Roubertoux, P.L. (2015). Finding Endophenotypes for Autism Spectrum Disorders (ASD): cDNA Microarrays and Brain Transcripts. In: Roubertoux, P. (eds) Organism Models of Autism Spectrum Disorders. Neuromethods, vol 100. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2250-5_8

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  • DOI: https://doi.org/10.1007/978-1-4939-2250-5_8

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-2249-9

  • Online ISBN: 978-1-4939-2250-5

  • eBook Packages: Springer Protocols

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