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Plant Immunophilins: A Protein Family with Diverse Functions Beyond Protein Folding Activity

  • Chapter
Elucidation of Abiotic Stress Signaling in Plants

Abstract

Immunophilins were discovered as cellular receptors for immunosuppressive drugs: cyclosporine A and FK506. Cyclophilins (CYPs, receptors for cyclosporine A) and FK506-binding proteins (FKBPs, receptors for FK506) do not share sequence homology, but have a common feature of peptidyl-prolyl cis-trans isomerase (PPIase) activity that catalyzes the cis-trans conversion of X-Pro peptide bonds, a rate-limiting step in the process of protein folding. Immunophilins are widely present in organisms from bacteria and fungi, to animals and plants. Genomics studies revealed that plants possess the largest immunophilin family. However, the physiological function of plant immunophilins is poorly understood. In this review, starting with a brief introduction of the immunophilin family and the current knowledge about their physiological roles in diverse organisms, the recent advances in the elucidation of plant immunophilin’s physiological roles, largely via functional genomics tools, are summarized here. Notably, a striking feature of plant immunophilins is that a large fraction is localized in the chloroplast. Recent studies reveal that chloroplast immunophilins play a central role in the assembly and maintenance of photosynthetic complexes.

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Acknowledgements

Research in AF’s lab is supported by funding from National Natural Science Foundation of China (No. 31270284) and BRJH of Shaanxi Province, China.

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  1. College of Life Sciences, Northwest University, 229 North Taibai Road, Xi’an, Shaanxi, 710069, China

    Lujing Shi & Aigen Fu

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  1. Lujing Shi
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Correspondence to Aigen Fu .

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  1. Department of Plant Molecular Biology, University of Delhi South Campus, Dhaula Kuan, India

    Girdhar K. Pandey

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Shi, L., Fu, A. (2015). Plant Immunophilins: A Protein Family with Diverse Functions Beyond Protein Folding Activity. In: Pandey, G. (eds) Elucidation of Abiotic Stress Signaling in Plants. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2211-6_14

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