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Genetic and Epigenetic Alterations in Testicular Tumors

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Genitourinary Pathology

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Abstract

Molecular alterations in cancer are gaining increasing importance as indicators of therapeutic response and prognosis. Abnormality in multiple loci in the genetic architecture and epigenetic factors could play a role in development of testicular germ cell tumors. The only recurrent cytogenetic alteration detected in testicular germ cell tumors is the gain of the short arm of chromosome 12. However, no single high-susceptibility gene has yet been found to play a major role. Genetic alterations involving chromosomes and genes, and epigenetic alterations including methylation, chromatin remodeling, and microRNA regulation are discussed.

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Authors and Affiliations

  1. Department of Pathology, Cleveland Clinic, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland, OH, USA

    Pallavi A. Patil MD & Prof. Cristina Magi-Galluzzi

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  1. Pallavi A. Patil MD
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  2. Prof. Cristina Magi-Galluzzi
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Correspondence to Cristina Magi-Galluzzi .

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Editors and Affiliations

  1. Department of Pathology, The Cleveland Clinic, Cleveland, Ohio, USA

    Cristina Magi-Galluzzi

  2. Department of Pathology, The Cleveland Clinic, Cleveland, Ohio, USA

    Christopher G. Przybycin

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Patil, P., Magi-Galluzzi, C. (2015). Genetic and Epigenetic Alterations in Testicular Tumors. In: Magi-Galluzzi, C., Przybycin, C. (eds) Genitourinary Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2044-0_42

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  • DOI: https://doi.org/10.1007/978-1-4939-2044-0_42

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