Abstract
Spitzoid melanoma is a controversial melanocytic malignant neoplasm. Although the 2009 Workshop of the International Melanoma Pathology Study Group has discouraged the usage of this term until this subset of melanomas can be more rigorously defined by phenotypic and genetic studies, spitzoid melanoma is still used to describe melanomas with architectural and/or cytologic features resembling Spitz nevus. Spitzoid melanoma indeed seems not to have its own distinguishing features but is defined in comparison with Spitz nevus, especially from a histological point of view.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Bibliography
Al Dhaybi R, Agoumi M, Gagné I, McCuaig C, Powell J, Kokta V. p16 expression: a marker of differentiation between childhood malignant melanomas and Spitz nevi. J Am Acad Dermatol. 2011;65:357–63.
Barnhill RL, Cerroni L, Cook M, et al. State of the art, nomenclature, and points of consensus and controversy concerning benign melanocytic lesions: outcome of an international workshop. Adv Anat Pathol. 2010;17:73.
Bastian BC, LeBoit PE, Pinkel D. Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features. Am J Pathol. 2000;157:967–72.
Gerami P, Scolyer RA, Xu X, et al. Risk assessment for atypical spitzoid melanocytic neoplasms using FISH to identify chromosomal copy number aberrations. Am J Surg Pathol. 2013;37:676–84.
Horst BA, Terrano D, Fang Y, Silvers DN, Busam KJ. 9p21 gene locus in Spitz nevi of older individuals: absence of cytogenetic and immunohistochemical findings associated with malignancy. Hum Pathol. 2013;44:2822–8.
Kamino H. Spitzoid melanoma. Clin Dermatol. 2009;27:545–55.
Kim JY, Choi JE, Ahn HH, Kye YC, Seo SH. A case of spitzoid melanoma with lymph node metastasis in a child. J Korean Med Sci. 2012;27:454–7.
King MS, Porchia SJ, Hiatt KM. Differentiating spitzoid melanomas from Spitz nevi through CD99 expression. J Cutan Pathol. 2007;34:576–80.
Mason A, Wititsuwannakul J, Klump VR, Lott J, Lazova R. Expression of p16 alone does not differentiate between Spitz nevi and spitzoid melanoma. J Cutan Pathol. 2012;39:1062–74.
Paradela S, Fonseca E, Pita-Fernández S, Prieto VG. Spitzoid and non-spitzoid melanoma in children. A prognostic comparative study. J Eur Acad Dermatol Venereol. 2013;27:1214–21.
Pol-Rodriguez M, Lee S, Silvers DN, et al. Influence of age on survival in childhood Spitzoid melanomas. Cancer. 2007;109:1579–83.
Puri PK, Ferringer TC, Tyler WB, Wilson ML, Kirchner HL, Elston DM. Statistical analysis of the concordance of immunohistochemical stains with the final diagnosis in spitzoid neoplasms. Am J Dermatopathol. 2011;33:72–7.
Requena C, Botella R, Nagore E, et al. Characteristics of spitzoid melanoma and clues for differential diagnosis with Spitz nevus. Am J Dermatopathol. 2012;34:478–86.
Requena C, Rubio L, Traves V, et al. Fluorescence in situ hybridization for the differential diagnosis between Spitz naevus and spitzoid melanoma. Histopathology. 2012;61:899–909.
Wititsuwannakul J, Mason AR, Klump VR, Lazova R. Neuropilin-2 as a useful marker in the differentiation between spitzoid malignant melanoma and Spitz nevus. J Am Acad Dermatol. 2013;68:129–3.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2015 Springer Science+Business Media New York
About this chapter
Cite this chapter
Rongioletti, F. (2015). Spitzoid Melanoma. In: Rare Malignant Skin Tumors. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2023-5_52
Download citation
DOI: https://doi.org/10.1007/978-1-4939-2023-5_52
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4939-2022-8
Online ISBN: 978-1-4939-2023-5
eBook Packages: MedicineMedicine (R0)