Abstract
Melanoma with signet-ring cells is a rare histological variant of melanoma first described in 1988. The challenge of this diagnosis lies in its mimicry with the more commonly seen adenocarcinoma with signet-ring cells, as there has been a suggestion that melanoma with signet-ring cells may be more often observed in metastatic or recurrent lesions. Interestingly, though unusual in human melanoma (estimated to occur in approximately 0.5 % of tumors), this morphological variant has been reported more frequently in animals.
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Shalin, S.C., Smoller, B.R. (2015). Signet-Ring Cell Melanoma. In: Rare Malignant Skin Tumors. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2023-5_47
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DOI: https://doi.org/10.1007/978-1-4939-2023-5_47
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