Abstract
Trichoblastoma is a basaloid neoplasm recapitulating follicular differentiation with many variants and classifications in the literature. Its malignant counterpart, trichoblastic carcinoma, is a term interpreted differently depending on the authority queried. The term “trichoblastic carcinoma” refers to a malignant trichogenic adnexal tumor. Some authors broadly apply this designation to any malignancy with follicular germinative differentiation, and as such, entities including fibroepithelioma of Pinkus and basal cell carcinoma are considered conceptually to represent trichoblastic carcinoma. Part of the argument in favor of this interpretation is the similar expression of adhesion molecules in developing follicles, the secondary hair germ, the outer root sheath, and basal cell carcinoma, as well as identical cytokeratin expression profiles in fetal hair follicles, trichoblastoma, and basal cell carcinoma.
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Kaley, J., Shalin, S., Smoller, B.R. (2015). Trichoblastic Carcinoma. In: Rare Malignant Skin Tumors. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2023-5_10
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DOI: https://doi.org/10.1007/978-1-4939-2023-5_10
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