Abstract
Branched chain amino acids (BCAA) may facilitate tumor growth; consequently, it is reasonable to assume that the dietary intake of BCAA may play a role in bladder carcinogenesis. To date, however, there is no epidemiological data relevant to a relationship of dietary BCAA with the risk of bladder cancer. On the other hand, there are a few experimental studies reported in the literature. This chapter focuses on the studies evaluating the effects of l-isoleucine and l-leucine on bladder carcinogenesis in experimental animals. These three studies employed a two-stage (initiation–promotion) carcinogenesis protocol with male F344 rats. The results show that the effects of dietary BCAA on rat bladder carcinogenesis is dependent on the type of basal diet used.
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Wei, M., Xie, XL., Yamano, S., Kakehashi, A., Wanibuchi, H. (2015). Isoleucine, Leucine and Their Role in Experimental Models of Bladder Carcinogenesis. In: Rajendram, R., Preedy, V., Patel, V. (eds) Branched Chain Amino Acids in Clinical Nutrition. Nutrition and Health. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1923-9_21
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DOI: https://doi.org/10.1007/978-1-4939-1923-9_21
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