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Photodynamic Therapy for the Management of Laryngeal Malignancies

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Biomedical Optics in Otorhinolaryngology

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Abstract

Carcinoma of the larynx accounts for 25–30 % of all carcinomas of the head and neck [1]. Early carcinomas of the larynx (Cis, T1, T2) and severe dysplasia are presently treated with either radiation therapy or surgery alone. Five-year cure rates achieved with this therapy is 75–90 %. Radiation therapy has the advantage of preserving the physical integrity of the larynx, thereby preserving the voice. Radiation therapy, however, has significant disadvantages even when small laryngeal fields of radiation are used. These disadvantages include discomfort and mucositis during and for potential prolonged periods after therapy, permanently altered voice quality, dysphagia, chondroradionecrosis of the larynx and trachea, and the extensive length of therapy (6–7 weeks) [2, 3]. Surgical therapy for early carcinomas, that is, T1 and T2, of the larynx includes performing a partial cordectomy or hemilaryngectomy. Although cure rates are high, surgical removal of portions of the vocal cord or hemilarynx results in significant alteration of the quality of voice [4].

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References

  1. Shah JP, Karnell LH, Hoffman HT, et al. Patterns of care for cancer of the larynx in the United States. Arch Otolaryngol Head Neck Surg. 1997;123:475–83.

    Article  CAS  PubMed  Google Scholar 

  2. VonEssen CF. Larynx and pyriform sinus. In: Fletcher GH, editor. Textbook of radiotherapy. Philadelphia: Lea & Febiger; 1982. p. 330–64.

    Google Scholar 

  3. Morris MR, Canonico D, Blank C. A critical review of radiotherapy in the management of T1 glottic carcinoma. Am J Otolaryngol. 1994;15(4):276–80.

    Article  CAS  PubMed  Google Scholar 

  4. Bailey BJ, Biller HF. Glottic carcinomas. In: Biller BJ, editor. Surgery of the Larynx. Philadelphia: W. B. Saunders; 1985. p. 257–77.

    Google Scholar 

  5. Le Q, Takamiya R, Shu H, et al. Treatment results of carcinoma in situ of the glottis. Arch Otolaryngol Head Neck Surg. 2000;126:1305–12.

    Article  CAS  PubMed  Google Scholar 

  6. Zeitels SM. Phonomicrosurgical treatment of early glottic cancer and carcinoma in situ. Am J Surg. 1996;172:704–9.

    Article  CAS  PubMed  Google Scholar 

  7. Smith JC, Johnson JT, Myers EN. Management and outcome of early glottic carcinoma. Otolaryngol Head Neck Surg. 2002;126(4):356–64.

    Article  PubMed  Google Scholar 

  8. Sittel C, Eckel H, Eschenburg C. Phonatory results after laser surgery for glottic carcinoma. Otolaryngol Head Neck Surg. 1998;119(4):418–24.

    Article  CAS  PubMed  Google Scholar 

  9. Chone CT, Yonehara E, Martins JEF, Altemani A, Crespo AN. Importance of anterior commissure in recurrence of early glottic cancer after laser endoscopic resection. Arch Otolaryngol Head Neck Surg. 2007;133(9):882–7.

    Article  PubMed  Google Scholar 

  10. Rucci L, Romagnoli P, Scala J. CO2 laser therapy in Tis and T1 glottic cancer: indications and results. Head Neck. 2010;32:392–8.

    PubMed  Google Scholar 

  11. Garcia-Serra A, Hinerman RW, Amdur RJ, Morris CG, Mendenhall WM. Radiotherapy for carcinoma in situ of the true vocal cords. Head Neck. 2002;24:390–4.

    Article  PubMed  Google Scholar 

  12. Damm M, Sittel C, Streppel M, Eckel HE. Transoral CO2 laser surgical management of glottic carcinoma in situ. Laryngoscope. 2002;110:1215–21.

    Article  Google Scholar 

  13. Khan MK, Koyfman SA, Hunter GK, Reddy CA, Saxton JP. Definitive radiotherapy for early (T1-2) glottic squamous cell carcinoma: a 20 year Cleveland clinic experience. Radiat Oncol. 2012;7:193.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Hafidh M, Tibbo J, Trites J, Corsten G, Hart RD, Nasser J, Wilke D, Taylor SM. Radiotherapy for T1 and T2 laryngeal cancer: the Dalhousie University experience. J Otolaryngol Head Neck Surg. 2009;38(4):434–9.

    PubMed  Google Scholar 

  15. Hartl DM, Ferlito A, Brasnu DR, Langendijk JA, Rinaldo A, Silver CE, Wolf GT. Evidence-based review of treatment options for patients with glottic cancer. Head Neck. 2011;33:1638–48.

    Article  PubMed  Google Scholar 

  16. Lee HS, Chun B, Kim SW, Kim ST, Oh JH, Hong JC, Lee KD. Transoral laser microsurgery for early glottic cancer as a one-stage single-modality therapy. Laryngoscope. 2013;123:2670–4.

    Article  PubMed  Google Scholar 

  17. Batella FN, Cueva MJC, Gonzalez BS, Pendas JLL, Gil G, Llames AL, Pantiga RA, Nieto CS. Voice quality after endoscopic laser surgery and radiotherapy for early glottis cancer: objective measurements emphasizing the Voice Handicap Index. Eur Arch Otorhinolaryngol. 2008;265:543–8.

    Article  Google Scholar 

  18. Freche C, DeCorbiere S. Use of photodynamic therapy in the treatment of vocal cord carcinoma. J Photochem Photobiol B. 1990;6:291–6.

    Article  CAS  PubMed  Google Scholar 

  19. Feyh J, Goetz A, Muller W, et al. Photodynamic therapy in head and neck surgery. J Photochem Photobiol B. 1990;7:353–8.

    Article  CAS  PubMed  Google Scholar 

  20. Gluckman JL. Hematoporphyrin photodynamic therapy: is there truly a future in head and neck oncology? Reflections on a 5-year experience. Laryngoscope. 1991;101:36–42.

    CAS  PubMed  Google Scholar 

  21. Schweitzer V. Photofrin-mediated photodynamic therapy for treatment of early stage oral cavity and laryngeal malignancies. Lasers Surg Med. 2001;29(4):305–13.

    Article  CAS  PubMed  Google Scholar 

  22. Biel MA. Photodynamic therapy and the treatment of head and neck neoplasia. Laryngoscope. 1998;108:1259–68.

    Article  CAS  PubMed  Google Scholar 

  23. Biel MA. Advances in photodynamic therapy for the treatment of head and neck cancer. Lasers Surg Med. 2006;38:349–55.

    Article  CAS  PubMed  Google Scholar 

  24. Rigual NR, Thankappan K, Cooper M, Sullivan MA, Dougherty T, Popat SR, Loree TR, Biel MA, Henderson B. Photodynamic therapy for head and neck dysplasia and cancer. Arch Otolaryngol Head Neck Surg. 2009;135(8):784–8.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Dilkes MG, DeJode ML. m-THPC photodynamic therapy for head and neck cancer. Lasers Med Sci. 1996;11(1):23–9.

    Article  Google Scholar 

  26. Grossman C, Zhu T, Finlay J, Dimofte A, Malloy K, O’Malley BO, Weinstein G, Busch TM, Quon H. Targeted laryngeal photodynamic therapy with a balloon diffusing light source. Photodiagn Photodyn Ther. 2010;7:158–61.

    Article  Google Scholar 

  27. Abramson AL, Shikowitz MJ, Mullooly VM, Steinberg BM, Hyman RB. Variable light-dose effect on photodynamic therapy for laryngeal papillomas. Arch Otolaryngol Head Neck Surg. 1994;120(8):852–5.

    Article  CAS  PubMed  Google Scholar 

  28. Shikowitz MJ, Abramson AL, Steinberg BM, DeVoti J, Bonagura VR, Mullooly V, Nouri M, Ronn AM, Inglis A, McClay J, Freeman K. Clinical trial of photodynamic therapy with meso-tetra (hydroxyphenyl) chlorin for respiratory papillomas. Arch Otolaryngol Head Neck Surg. 2005;131(2):99–105.

    Article  PubMed  Google Scholar 

  29. Silbergleit AK, Somers ML, Schweitzer VG, Gardner GM, Peterson E. Vocal fold vibration after photofrin-mediated photodynamic therapy for treatment of early-stage laryngeal malignancies. J Voice. 2013;27(6):762–4.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA

    Merrill A. Biel MD, PhD

  2. Virginia Piper Cancer Institute, Abbott Northwestern Hospital, 2211 Park Avenue South, Minneapolis, MN, 55404, USA

    Merrill A. Biel MD, PhD

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  1. Merrill A. Biel MD, PhD
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Correspondence to Merrill A. Biel MD, PhD .

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Editors and Affiliations

  1. Department of Otolaryngology Head and Neck Surgery, Department of Biomedical Engineering, Division of Facial Plastic Surgery, The Beckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California, USA

    Brian J.-F. Wong

  2. Department of Otorhinolaryngology, Plastic, Head and Neck Surgery, RWTH Aachen University Hospital, Aachen, Germany

    Justus Ilgner

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Biel, M.A. (2016). Photodynamic Therapy for the Management of Laryngeal Malignancies. In: Wong, BF., Ilgner, J. (eds) Biomedical Optics in Otorhinolaryngology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1758-7_23

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  • DOI: https://doi.org/10.1007/978-1-4939-1758-7_23

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-1757-0

  • Online ISBN: 978-1-4939-1758-7

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