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Humanized Mice as Models for Human Disease

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Humanized Mice for HIV Research

Abstract

The optimization and standardization of humanized mouse models has been ongoing for many years now, with development of specific models that have unique applications for discovery research and preclinical analysis of antiviral drugs. In this review, we strive to place this continuum of work into perspective, both to provide an historical footing to its progress and to urge attention to obstacles that continue to confront the full application of these models to the analysis of human disease.

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Acknowledgements

We would like to thank Drs. Sandra Bridges, Cheryl Stoddart, and Jerry Zack for their careful reading of this manuscript as well as for their many contributions to humanized mouse technology.

Author information

Authors and Affiliations

  1. Divison of Experimental Medicine, Department of Medicine, University of California, UCSF Box 1234, 94143-1234, San Francisco, CA, USA

    Joseph M. McCune MD, PhD

  2. 1001 Potrero Ave. Building 3, 6th Floor, Room 601, 94110, San Francisco, CA, USA

    Joseph M. McCune MD, PhD

  3. Jackson Laboratory, Bar Harbor, ME, USA

    Leonard D. Shultz

Authors
  1. Joseph M. McCune MD, PhD
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  2. Leonard D. Shultz
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Corresponding author

Correspondence to Joseph M. McCune MD, PhD .

Editor information

Editors and Affiliations

  1. Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA

    Larisa Y. Poluektova

  2. Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

    J. Victor Garcia

  3. Research Center for AIDS Laboratory of Viral Pathogenesis, Kyoto University Institute for Virus Research, Sakyo-ku, Japan

    Yoshio Koyanagi

  4. Division of Hematology, University Hospital Zürich, Zürich, Switzerland

    Markus G. Manz

  5. Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA

    Andrew M. Tager

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McCune, J., Shultz, L. (2014). Humanized Mice as Models for Human Disease. In: Poluektova, L., Garcia, J., Koyanagi, Y., Manz, M., Tager, A. (eds) Humanized Mice for HIV Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1655-9_2

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