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Rabbit Monoclonal Antibodies

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Handbook of Practical Immunohistochemistry

Abstract

Rabbit monoclonal antibodies are relatively new in the immunohistochemistry (IHC) field. The majority of rabbit monoclonal antibodies are developed using a patented and proprietary rabbit hybridoma technology—the RabMAb® hybridoma technology. RabMAb primary antibodies offer greater advantages over classic mouse monoclonal antibodies, providing higher binding affinity, more diversified antigenic epitope recognition and a highly stable IgG structure. Since the inception of this technology in early 2000s, RabMAb primary antibodies have quickly replaced mouse monoclonal antibodies for several important markers such as HER2, c-kit/CD117, estrogen receptor and progesterone receptor in the pathology IHC field. RabMAb primary antibodies improve the effectiveness of certain markers that have been especially difficult in pathology IHC such as ERG, c-myc, bcl-2, MSH-6, MSH2 and PMS2. Because RabMAb primary antibodies offer superior sensitivity and specificity, performance reliability, as well as easy adaption to current automated stainers, it is clear that this group of antibodies is becoming the preferred choice for performing IHC in pathology laboratories.

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Abbreviations

RabMAb® :

Rabbit monoclonal antibody developed using a patented and Epitomics’ proprietary rabbit hybridoma technology

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Author information

Authors and Affiliations

  1. SVP, Antibody Technology, Abcam, Burlingame Site, 863 Mitten Road, Burlingame, CA, 94010, USA

    Weimin Zhu MS, MBA

  2. In Vitro Diagnostics, Epitomics – An Abcam® Company, Burlingame, CA, USA

    Aihua Li MD, PhD & Taiying Chen MD, PhD

Authors
  1. Weimin Zhu MS, MBA
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  2. Aihua Li MD, PhD
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  3. Taiying Chen MD, PhD
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Corresponding author

Correspondence to Weimin Zhu MS, MBA .

Editor information

Editors and Affiliations

  1. Laboratory Medicine, Geisinger Health System, Danville, Pennsylvania, USA

    Fan Lin

  2. Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania, USA

    Jeffrey Prichard

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© 2015 Springer Science+Business Media New York

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Zhu, W., Li, A., Chen, T. (2015). Rabbit Monoclonal Antibodies. In: Lin, F., Prichard, J. (eds) Handbook of Practical Immunohistochemistry. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1578-1_7

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  • DOI: https://doi.org/10.1007/978-1-4939-1578-1_7

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-1577-4

  • Online ISBN: 978-1-4939-1578-1

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