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Bone Marrow

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Handbook of Practical Immunohistochemistry

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Abstract

This chapter provides an overview of immunohistochemical markers used frequently in assessing bone marrow diseases. These disease entities include: lymphoid and myeloid leukemias, both acute and chronic, lymphoproliferative disorders, T and B cell neoplasms/lymphomas, myeloproliferative neoplasms, myelodysplastic syndromes, mast cell disease, plasma cell dyscrasias and metastatic tumors to the bone marrow.

There is quite a bit of overlap between the markers used in the bone marrow workup for lymphoid diseases and lymphoma (Chap. 30), thus a review of that chapter might be helpful in the workup of lymphoproliferative disorders.

Also the marrow can be the site for metastatic tumors. The workup of metastatic disease to the marrow is the same as in any other site (Chap. 11) with the exception of markers that are rendered useless by the decalcification process.

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Authors and Affiliations

  1. Laboratory medicine, Geisinger Medical Center, 100 N. Academy Ave, Danville, PA, 17822, USA

    R. Patrick Dorion MD

  2. Department of Pathology and Laboratory Medicine, Geisinger Health System, Wilkes-Barre, PA, USA

    Xiaohong (Mary) Zhang MD, PhD

Authors
  1. R. Patrick Dorion MD
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  2. Xiaohong (Mary) Zhang MD, PhD
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Correspondence to R. Patrick Dorion MD .

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Editors and Affiliations

  1. Laboratory Medicine, Geisinger Health System, Danville, Pennsylvania, USA

    Fan Lin

  2. Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania, USA

    Jeffrey Prichard

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Dorion, R.P., Zhang, X.(. (2015). Bone Marrow. In: Lin, F., Prichard, J. (eds) Handbook of Practical Immunohistochemistry. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1578-1_31

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  • DOI: https://doi.org/10.1007/978-1-4939-1578-1_31

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-1577-4

  • Online ISBN: 978-1-4939-1578-1

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