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Testis and Paratesticular Tissues

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Handbook of Practical Immunohistochemistry

Abstract

The diagnosis of testicular neoplasms is often based solely on morphologic pattern recognition, but there are newer markers that can play a significant role in the identification of germ cell tumors such as SALL4, Nanog, LIN28 and OCT4. Similarly, GAL-3 and other newer markers can be helpful in the identification of sex cord/stromal tumors. Many of the markers used in the identification of testicular tumors may be present in normal testicular cells as well, but their expression patterns may change according to the life stage of the patient. This chapter attempts to address that question, although the literature is somewhat sparse. Markers of normal paratesticular epithelia are included, as well as markers in paratesticular tumors and adenocarcinomas in the male pelvis. Basic algorithms are provided to assist in the workup of testicular and paratesticular neoplasms.

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Authors and Affiliations

  1. Department of Laboratory Medicine, Geisinger Medical Center, 100 N. Academy Avenue, MC 01-31, Danville, PA, 17822-0131, USA

    Myra L. Wilkerson MD

  2. Pathology and Urology, Indiana University School of Medicine, Indianapolis, IN, USA

    Liang Cheng MD

  3. Molecular Pathology Laboratory, Indiana University School of Medicine, Indianapolis, IN, USA

    Liang Cheng MD

  4. Genitourinary Pathology Division, Indiana University School of Medicine, Indianapolis, IN, USA

    Liang Cheng MD

  5. Urologic Pathology, Indiana University School of Medicine, Indianapolis, IN, USA

    Liang Cheng MD

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  1. Myra L. Wilkerson MD
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  2. Liang Cheng MD
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Correspondence to Myra L. Wilkerson MD .

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Editors and Affiliations

  1. Laboratory Medicine, Geisinger Health System, Danville, Pennsylvania, USA

    Fan Lin

  2. Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania, USA

    Jeffrey Prichard

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Wilkerson, M.L., Cheng, L. (2015). Testis and Paratesticular Tissues. In: Lin, F., Prichard, J. (eds) Handbook of Practical Immunohistochemistry. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1578-1_24

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