Abstract
Gastrinoma is the second most common islet cell tumor of the pancreas and the most common symptomatic malignant endocrine tumor of the pancreas. Gastrinomas are associated with Zollinger-Ellison syndrome (ZES), which is characterized by severe peptic ulcer disease, hypersecretion of gastric acid, and a non-beta islet cell tumor of the pancreas. This tumor is now understood to be a gastrin-secreting duodenal or pancreatic neuroendocrine tumor—or gastrinoma—and it is the cause of peptic ulcer disease in 0.1–1 % of patients. ZES occurs sporadically in 75–80 % of cases and as part of multiple endocrine neoplasia I in the rest.
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© 2015 Springer New York
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Gwinn, E.C. (2015). Gastrinoma. In: Saclarides, T., Myers, J., Millikan, K. (eds) Common Surgical Diseases. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1565-1_27
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DOI: https://doi.org/10.1007/978-1-4939-1565-1_27
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