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Applications of Polyethylene Oxide (POLYOX) in Hydrophilic Matrices

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Hydrophilic Matrix Tablets for Oral Controlled Release

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 16))

Abstract

Polyethylene oxide (PEO), a hydrophilic water-soluble synthetic polymer, provides a useful alternative to HPMC for hydrophilic matrix applications. It is an effective matrix former, with high viscosity and swelling capacity, in addition to its good processing characteristics that aid tablet manufacture. The broad range of molecular weight grades available allows drug release to be tailored for different profiles across a wide range of drug dose and solubility combinations. Matrices can provide zero-order release profiles for soluble drugs. Long-term stability is aided by inclusion of an antioxidant and judicious choice of fillers at the formulation stage. Various formulation and processing studies are presented in this chapter using model formulation cases.

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Author information

Authors and Affiliations

  1. Colorcon Global Headquarters, Harleysville, PA, USA

    Lawrence M. Martin & Ali R. Rajabi-Siahboomi Ph.D.

Authors
  1. Lawrence M. Martin
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  2. Ali R. Rajabi-Siahboomi Ph.D.
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Corresponding author

Correspondence to Ali R. Rajabi-Siahboomi Ph.D. .

Editor information

Editors and Affiliations

  1. Drug Product Science and Technology, Bristol-Myers Squibb, Moreton, Merseyside, United Kingdom

    Peter Timmins

  2. Commercial Trade Channels, Merck, Sharp and Dohme, Hoddesdon, Hertfordshire, United Kingdom

    Samuel R. Pygall

  3. School of Pharmacy, University of Nottingham, Notthingham, Nottinghamshire, United Kingdom

    Colin D. Melia

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© 2014 American Association of Pharmaceutical Scientists

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Martin, L.M., Rajabi-Siahboomi, A.R. (2014). Applications of Polyethylene Oxide (POLYOX) in Hydrophilic Matrices. In: Timmins, P., Pygall, S., Melia, C. (eds) Hydrophilic Matrix Tablets for Oral Controlled Release. AAPS Advances in the Pharmaceutical Sciences Series, vol 16. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1519-4_5

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