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Natural Polysaccharides in Hydrophilic Matrices

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Hydrophilic Matrix Tablets for Oral Controlled Release

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 16))

Abstract

Natural polysaccharides and their modified derivatives can provide useful alternatives to the use of cellulose ethers in hydrophilic matrix tablets. They are chemically diverse and originate from a broad range of plant and microbial sources. They are widely available for use in foods, and modified starches and xanthan gum in particular have been studied as matrix carriers. Many have additional properties which can be used to advantage in extended-release applications. Their ability to form regular molecular structures and to interact with drugs and other polymers can be particularly useful. They have found application not only in conventional extended-release matrices but also in specialised matrices for targeting different regions of the gastrointestinal tract.

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Authors and Affiliations

  1. School of Pharmacy, University of Nottingham, Nottingham, UK

    Colin D. Melia Ph.D.

  2. Drug Product Science and Technology, Bristol-Myers Squibb, Moreton, Merseyside, UK

    Peter Timmins Ph.D.

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  1. Colin D. Melia Ph.D.
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  2. Peter Timmins Ph.D.
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Correspondence to Colin D. Melia Ph.D. .

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  1. Drug Product Science and Technology, Bristol-Myers Squibb, Moreton, Merseyside, United Kingdom

    Peter Timmins

  2. Commercial Trade Channels, Merck, Sharp and Dohme, Hoddesdon, Hertfordshire, United Kingdom

    Samuel R. Pygall

  3. School of Pharmacy, University of Nottingham, Notthingham, Nottinghamshire, United Kingdom

    Colin D. Melia

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Melia, C.D., Timmins, P. (2014). Natural Polysaccharides in Hydrophilic Matrices. In: Timmins, P., Pygall, S., Melia, C. (eds) Hydrophilic Matrix Tablets for Oral Controlled Release. AAPS Advances in the Pharmaceutical Sciences Series, vol 16. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1519-4_4

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