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Ontogeny of Antioxidant Systems

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Perinatal and Prenatal Disorders

Abstract

Changes in the redox conditions of the biosphere have shaped the evolution of biological adaptations that permit successful energy capture and transfer by life forms. These include the systems that can scavenge molecular oxygen and nitrogen oxides. Mammalian development partly recapitulates this sequence as the zygote implants and undergoes early development in a low oxygen environment, ultimately developing a vascular supply that supports gas exchange and metabolism, as well as the enzymatic antioxidant/antinitrosant systems required to handle the burden. These systems differ among the organ systems, and their function and expression are dependent on the stage of development and the particular metabolic demands, as well as the exposure to redox stress.

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Authors and Affiliations

  1. Neonatal-Perinatal Research Institute, Duke University Medical Center, 365 Sands Laboratory Building, DUMC Box 3373, Research Drive, Durham, NC, 27710, USA

    Richard L. Auten Jr. M.D.

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  1. Richard L. Auten Jr. M.D.
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Correspondence to Richard L. Auten Jr. M.D. .

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Editors and Affiliations

  1. University of Penn, Perelman Sch of Med Professor of Pediatrics, Children's Hospital of Philadelphia Division of Neonatology, Philadelphia, Pennsylvania, USA

    Phyllis A. Dennery

  2. Lab of Oxidative Stress Policlinico “Le Scotte“, University of Siena Dept of Peds, Obstetrics & Reprod Med, Siena, Italy

    Giuseppe Buonocore

  3. Department of Pediatrics, University of Oslo Faculty of Medicine Rikshospitalit Medical Center, Oslo, Norway

    Ola Didrik Saugstad

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Auten, R.L. (2014). Ontogeny of Antioxidant Systems. In: Dennery, P., Buonocore, G., Saugstad, O. (eds) Perinatal and Prenatal Disorders. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1405-0_17

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