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Pediatric Research: Designing, Implementing, and Interpreting Strong Trials

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Pediatric Sedation Outside of the Operating Room

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Abstract

Clinical research is vital to generate the evidence to guide clinical practice. Clinical research may be qualitative or quantitative, and observational or interventional. A trial is an important form of interventional research designed to assess the effectiveness of a therapy. Trials may be efficacy trials focused on assessing efficacy in ideal circumstances or effectiveness trials conducted in wider real-life populations.

The most important aspect of good research is the research question. A good question is relevant and clearly defined. To be useful, a research study must be well designed and conducted well. Qualified statistical input is needed for nearly all high-quality research projects—particularly trials.

Research in children is challenging for many reasons including ethics, heterogeneity, and a paucity of validated outcome measures and basic pharmacological knowledge.

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Author information

Authors and Affiliations

  1. Department of Anaesthesia and Pain Management, The Royal Children’s Hospital Melbourne, Murdoch Children’s Research Institute, Melbourne, VIC, Australia

    Andrew Davidson M.B.B.S., M.D., F.A.N.Z.C.A.

Authors
  1. Andrew Davidson M.B.B.S., M.D., F.A.N.Z.C.A.
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Corresponding author

Correspondence to Andrew Davidson M.B.B.S., M.D., F.A.N.Z.C.A. .

Editor information

Editors and Affiliations

  1. Department of Anesthesiology, Harvard Medical School, Boston, Massachusetts, USA

    Keira P. Mason

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Davidson, A. (2015). Pediatric Research: Designing, Implementing, and Interpreting Strong Trials. In: Mason, K. (eds) Pediatric Sedation Outside of the Operating Room. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1390-9_33

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  • DOI: https://doi.org/10.1007/978-1-4939-1390-9_33

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-1389-3

  • Online ISBN: 978-1-4939-1390-9

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