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Polarized Activation of Macrophages

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Macrophages: Biology and Role in the Pathology of Diseases

Abstract

Macrophages are mononuclear phagocytes which play important roles in many aspects of immunity, tissue repair and metabolism. Plasticity is a key feature of these cells and consists in the capability to modulate their phenotypic and functional aspects under distinct stimuli derived from the microenvironment. A number of transcription factors, epigenetic mechanisms, and post-transcriptional events have been recently described to regulate macrophage activation, differentiation and polarization, thus accounting for a fine modulation of the functions of these cells. This increasing body of evidence opens the way to new therapeutic approaches aimed at targeting specific polarized macrophage subsets (or activation states) in a number of pathological contexts.

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Acknowledgments

Alberto Mantovani is supported by AIRC (Investigator Grant and 5x1000 Grant). Maria Rosaria Galdiero is supported by a fellowship from P.O.R. Campania FSE 2007–2013, Project “CREMe”. Subhra K Biswas is supported by funding from SIgN, Biomedical Research Council, A*STAR, Singapore.

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Authors and Affiliations

  1. IRCCS Humanitas Clinical and Research Center, via Manzoni 56, 20089, Rozzano (Milan), Italy

    Maria Rosaria Galdiero

  2. Division of Clinical Immunology and Allergy, University of Naples Federico II, via Pansini 5, 80131, Naples, Italy

    Maria Rosaria Galdiero

  3. Singapore Immunology Network (SIgN), Biomedical Sciences Institutes, A*STAR, 8A Biomedical Grove; #04 Immunos Building, Singapore, Singapore

    Subhra K. Biswas

  4. IRCCS Humanitas Clinical and Research Center, Humanitas University, via Manzoni 56, 20089, Rozzano (Milan), Italy

    Alberto Mantovani

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  1. Maria Rosaria Galdiero
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  3. Alberto Mantovani
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Correspondence to Alberto Mantovani .

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  1. Singapore Immunology Network (SIgN) Biomedical Sciences Institutes, A*STAR, Singapore, Singapore

    Subhra K. Biswas

  2. IRCCS Humanitas Clinical and Research Institute, Humanitas University, Rozzano, Italy

    Alberto Mantovani

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Galdiero, M.R., Biswas, S.K., Mantovani, A. (2014). Polarized Activation of Macrophages. In: Biswas, S., Mantovani, A. (eds) Macrophages: Biology and Role in the Pathology of Diseases. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1311-4_2

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