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Nicotinic Acetylcholine Receptors and the Roles of the Alpha7 Subunit

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Nicotinic Receptors

Part of the book series: The Receptors ((REC,volume 26))

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Abstract

Nicotinic acetylcholine receptors (nAChR) are members of the Cys-loop superfamily of ligand-gated ion channels that includes glycine, γ-aminobutyric acid (GABAA), and serotonin receptor channels. The members of the family are defined by a similar pentameric structure with five membrane-spanning subunits surrounding a central water-filled, cation-selective pore. The nAChRs are further divided into muscle and neuronal types. Muscle nAChRs comprise α1, β1, γ, and δ or ε subunits in a 2:1:1:1 stoichiometric ratio. Neuronal type nAChRs are composed of differing combinations of α and β subunits, with nine genes encoding α subunits (α2–10) and three encoding β subunits (β2–4). This review focuses on the α7 subunit, which was cloned from the chicken in 1990 and from the rat in 1993. α7 has received waning and waxing attention as its involvement in diseases, including Alzheimer’s disease and lung cancer, has been defined and redefined. For example, recent reports provide increasing evidence for α7’s involvement in the pathogenesis of Alzheimer’s disease, suggesting that further work is warranted to understand the roles of the α7 subunit normally and in pathophysiology.

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Authors and Affiliations

  1. Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA

    Michael Paolini M.D.

  2. Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Mariella De Biasi Ph.D.

  3. Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, 415 Curie Boulevard, Clinical Research Building, Philadelphia, PA, USA

    John A. Dani Ph.D.

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  1. Michael Paolini M.D.
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Correspondence to John A. Dani Ph.D. .

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  1. Department of Neurobiology SHEL 1006, University of Alabama at Birmingham, Birmingham, Alabama, USA

    Robin A.J. Lester

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Paolini, M., De Biasi, M., Dani, J.A. (2014). Nicotinic Acetylcholine Receptors and the Roles of the Alpha7 Subunit. In: Lester, R. (eds) Nicotinic Receptors. The Receptors, vol 26. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1167-7_13

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