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Umbilical Cord Blood for Cardiovascular Cell Therapy

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Perinatal Stem Cells

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Abstract

Cardiovascular diseases, including atherosclerosis, hypertension, and heart failure, remain major causes of morbidity and mortality with substantial economic cost worldwide. Unlike other vertebrate animals, it was postulated that heart cells in adult mammals did not have self-regenerative potential. However, the basic foundations of cardiac regeneration changed radically in the 1990s owing to pioneering studies with significant biological and clinical implications. Since then, most efforts have been directed to repair myocardial tissue and the supportive vascular system using cells with regenerative potential. In this context, to highlight the great potential of UCB in human regenerative medicine, we first provide a broad overview of current advances, pitfalls, and future goals, focusing on cardiac regeneration. We then show UCB, in the context of other existing potential cell sources, as a rich reservoir of both hematopoietic and nonhematopoietic cells with regenerative capacity. We finally recount ongoing research using UCB-derived cells, focused on cardiovascular cell therapy.

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Authors and Affiliations

  1. Heart Failure and Cardiac Regeneration (ICREC) Research Program, Fundació Institut d´Investigació en Ciències de la Salut, Germans Trias i Pujol, Badalona, Spain

    Santiago Roura Ferrer Ph.D. & Carolina Gálvez-Montón D.V.M., Ph.D.

  2. Heart Failure and Cardiac Regeneration (ICREC) Research Program, Cardiology Service, Hospital Universitari Germans Trias i Pujol, Badalona, Spain

    Antoni Bayés-Genís M.D., Ph.D.

  3. Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain

    Antoni Bayés-Genís M.D., Ph.D.

Authors
  1. Santiago Roura Ferrer Ph.D.
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  2. Carolina Gálvez-Montón D.V.M., Ph.D.
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  3. Antoni Bayés-Genís M.D., Ph.D.
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Corresponding author

Correspondence to Antoni Bayés-Genís M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Wake Forest Baptist Medical Center, Institute for Regenerative Medicine, Winston-Salem, North Carolina, USA

    Anthony Atala

  2. Wake Forest Baptist Medical Center, Institute for Regenerative Medicine, Winston-Salem, North Carolina, USA

    Sean V. Murphy

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Ferrer, S.R., Gálvez-Montón, C., Bayés-Genís, A. (2014). Umbilical Cord Blood for Cardiovascular Cell Therapy. In: Atala, A., Murphy, S. (eds) Perinatal Stem Cells. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1118-9_26

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