Abstract
Intraoperative consultations for central nervous system disease may be challenging due to limitations of sample size, lack of familiarity with neurosurgical procedures, or poor access to neuroimaging studies. Despite these challenges, the surgical pathologist is charged with determining if the tissue sample is representative of the pathologic process while ensuring that enough diagnostic tissue has been retained for routine histology, immunohistochemistry, fluorescence in situ hybridization, molecular testing, and in some cases, tissue banking. Here, we present basic methods and a practical approach for CNS intraoperative consultation including critical pre-analytic considerations that promote optimal tissue management.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Wippold FJ (2010) Neuroradiology: the surrogate of gross neuropathology. In: Perry A, Brat DJ (eds) Practical surgical neuropathology: a diagnostic approach. Churchill, Livingstone, Elsevier, Inc., Philadelphia, pp 47–62
Fuller GN (2010) Intraoperative consultation and optimal processing. In: Perry A, Brat DJ (eds) Practical surgical neuropathology: a diagnostic approach. Churchill, Livingstone, Elsevier, Inc., Philadelphia, pp 35–45
Burger PC (2009) Smears and frozen sections in surgical neuropathology. PB Medical Publishing, Baltimore
Adesina AM (2005) Intraoperative consultation in the diagnosis of pediatric brain tumors. Arch Pathol Lab Med 129:1653–1660
Powell SZ (2005) Inraoperative consultations, cytologic preparation, and frozen section in the central nervous system. Arch Pathol Lab Med 129:1635–1652
Yachnis AT (2002) Intraoperative consultation for nervous system lesions. Semin Diagn Pathol 19:192–206
Burger PC (1985) Use of cytological preparations in the frozen section diagnosis of central nervous system neoplasia. Am J Surg Pathol 9:344–354
Folkerth RD (1994) Smears and frozen sections in the intraoperative diagnosis of central nervous system lesions. Neurosurg Clin N Am 5:1–18
Perry A, Brat DJ (2010) Practical surgical neuropathology: a diagnostic approach. Churchill, Livingstone, Elsevier, Inc., Philadelphia
Brat DJ, Prayson RA, Ryken TC et al (2008) Diagnosis of glioma: role of neuropathology. J Neurooncol 89:287–311
Dunbar E, Yachnis AT (2010) Glioma diagnosis: immunohistochemistry and beyond. Adv Anat Pathol 17:187–201
Rivera-Zengotita M, Yachnis AT (2012) Gliosis vs. glioma: don’t grade until you know. Adv Anat Pathol 19:239–249
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Science+Business Media, New York
About this protocol
Cite this protocol
Kresak, J.L., Rivera-Zengotita, M., Foss, R.M., Yachnis, A.T. (2014). CNS Intraoperative Consultation: A Survival Guide for Non-neuropathologists. In: Day, C. (eds) Histopathology. Methods in Molecular Biology, vol 1180. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1050-2_22
Download citation
DOI: https://doi.org/10.1007/978-1-4939-1050-2_22
Published:
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-1049-6
Online ISBN: 978-1-4939-1050-2
eBook Packages: Springer Protocols