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Regenerative Medicine and the Search for Pluripotent/Multipotent Stem Cells

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Adult Stem Cell Therapies: Alternatives to Plasticity

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Hematopoietic stem cells isolated from bone marrow (BM), mobilized peripheral blood (mPB), and umbilical cord blood (UCB) have been employed for many years as sources of stem cells for hematopoietic transplants. Based on this encouraging experience, regenerative medicine is searching for stem cells that can be safely and efficiently employed for regeneration of damaged solid organs (e.g., heart, brain, or liver). Ideal for this purpose would be pluripotent stem cells (PSCs), which, according to their definition, have broad potential to differentiate into cells from all three germ layers (meso-, ecto-, and endoderm). Based on encouraging data in experimental animals, several types of stem cells isolated from embryonic and adult tissues have been proposed for solid organ regeneration, with some showing promise for treating patients. In this chapter, we will discuss the current status of different types of stem cells that have potential application in regenerative medicine.

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Acknowledgements

This work was supported by NIH grants 2R01 DK074720 and R01HL112788, the Stella and Henry Endowment, and Maestro grant 2011/02/A/NZ4/00035 to MZR.

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  1. Stem Cell Institute, James Graham Brown Cancer Center, University of Louisville, 500 South Floyd Street, Rm. 107, 40202, Louisville, KY, USA

    Prof. Mariusz Z. Ratajczak MD, PhD

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Correspondence to Mariusz Z. Ratajczak MD, PhD .

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  1. University of Louisville, Stem Cell Institute, James Graham Brown Cancer Center, Louisville, Kentucky, USA

    Mariusz Z. Ratajczak

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Ratajczak, M. (2014). Regenerative Medicine and the Search for Pluripotent/Multipotent Stem Cells. In: Ratajczak, M. (eds) Adult Stem Cell Therapies: Alternatives to Plasticity. Stem Cell Biology and Regenerative Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1001-4_1

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