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Kaposi’s Sarcoma-Associated Herpesvirus: Pathogenesis and Host Immune Response

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Viruses and Human Cancer

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Abstract

Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 or HHV-8 is a member of the family of gammaherpesviruses. The virus was first discovered by Drs. Yuan Chang and Patrick Moore in 1994 in Kaposi sarcoma lesions from HIV-infected individuals. This virus is also associated with two lymphoproliferative diseases, named primary effusion lymphoma and multicentric Castleman’s disease. In this chapter, we describe aspects of the latent and lytic phases of the KSHV lifecycle. We also discuss the function of different viral genes that help the virus survive in the infected host.

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Acknowledgments

We thank the Damania lab members for helpful discussions. B.D. is supported by NIH grants CA096500, 019014, AI107810, AI109965, DE018281, and DE023946. B.D. is a Leukemia & Lymphoma Society Scholar and a Burroughs Wellcome Fund Investigator in Infectious Disease. Due to space constraints, we apologize for not referencing many other publications in this chapter.

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  1. Department of Microbiology and Immunology, Lineberger Cancer Center, CB#7295, University of North Carolina at Chapel Hill, Room 31-303, Chapel Hill, NC, 27599, USA

    Louise Giffin, Penny Anders & Blossom Damania Ph.D.

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  1. Louise Giffin
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  2. Penny Anders
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  3. Blossom Damania Ph.D.
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Correspondence to Blossom Damania Ph.D. .

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  1. Pathology and Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA

    S. David Hudnall

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Giffin, L., Anders, P., Damania, B. (2014). Kaposi’s Sarcoma-Associated Herpesvirus: Pathogenesis and Host Immune Response. In: Hudnall, S. (eds) Viruses and Human Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0870-7_12

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