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Kaposi Sarcoma-Associated Herpesvirus (KSHV) or Human Herpesvirus 8 (HHV-8)

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Cancers in People with HIV and AIDS

Abstract

Kaposi sarcoma-associated herpesvirus (KSHV) or Human herpesvirus 8 (HHV-8) is a virus that is associated with the original AIDS-defining tumor, Kaposi sarcoma (KS). This virus is necessary for the development of KS. Expression of the viral protein, LANA, represents the definitive diagnostic marker for KS. In addition to KS, KSHV is also associated with primary effusion lymphoma and a plasmablastic variant of multicentric Castleman disease.

KSHV is a double-stranded DNA virus. There exists no vaccine against this virus. Viral DNA replication is sensitive to gancyclovir. The virus establishes life-long latency in the infected host.

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Acknowledgments

We apologize for not referencing all possible publications due to space limitations. BD is supported by grants AI109965, CA096500, DE018281, and CA019014 and is a Leukemia & Lymphoma Society Scholar and a Burroughs Wellcome Fund Investigator in Infectious Disease. DD is supported by grants DE023946, AI107810, and CA163217.

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  1. Program in Global Oncology, Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina, CB#7295, Chapel Hill, NC, 27599, USA

    Blossom Damania & Dirk P. Dittmer

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  1. Blossom Damania
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Correspondence to Blossom Damania .

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  1. National Cancer Institute HIV/AIDS Malignancy Branch, National Institutes of Health, Bethesda, Maryland, USA

    Robert Yarchoan

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Damania, B., Dittmer, D.P. (2014). Kaposi Sarcoma-Associated Herpesvirus (KSHV) or Human Herpesvirus 8 (HHV-8). In: Yarchoan, R. (eds) Cancers in People with HIV and AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0859-2_5

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