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The DNA Methylation Signature of Smoking: An Archetype for the Identification of Biomarkers for Behavioral Illness

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Genes and the Motivation to Use Substances

Part of the book series: Nebraska Symposium on Motivation ((NSM,volume 61))

Abstract

Smoking is perhaps the foremost public health challenge in the USA and in the world. In a series of rapidly emerging studies, we and others have demonstrated that cigarette smoking is associated with changes in the DNA methylation signature of peripheral blood cells. The changes associated with this type of substance use are both dose and time dependent. These changes in DNA methylation are also accompanied by changes in gene transcription and protein expression whose patterns are furthermore indicative of increased vulnerability to other forms of complex illness. In the past, our efforts to translate this knowledge into actionable information have been stymied by a lack of methods through which to systematically assess these changes. The rapid advance of DNA methylation assessment technologies changes that dynamic and presents the possibility that methylation-based clinical tools to aid the ascertainment of smoking status or effectiveness of treatment can be developed. In this chapter, we review the latest advances in this field and discuss how these advances allow us insight as to methods through which to prevent smoking and shed insight into optimizing strategies through which to identify biomarkers for other behavioral illnesses which share similar contributions from environmental and gene–environmental interaction effects.

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Acknowledgments

The work in this study was supported in part by MH080898 and DA03434457 to Dr. Philibert. Additional support was derived from the Center for Contextual Genetics and Prevention Science (Grant Number P30 DA027827, Dr. Gene Brody) funded by the National Institute on Drug Abuse. Intellectual property right claims are pending on some of the material related to this manuscript on behalf of Dr. Philibert. Finally, Dr. Philibert is the chief scientific officer and part owner of Behavioral Diagnostics, Inc., a firm which is developing epigenetic tests for the market place.

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Authors and Affiliations

  1. Department of Psychiatry, University of Iowa, Rm 2-126 MEB, 52242-1009, Iowa, IA, USA

    Robert A. Philibert

  2. The Center for Family Research, University of Georgia, 30605-6616, Athens, GA, USA

    S.R.H. Beach & Gene H. Brody

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  1. Robert A. Philibert
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  2. S.R.H. Beach
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  3. Gene H. Brody
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Correspondence to Robert A. Philibert or S.R.H. Beach .

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  1. Psychology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA

    Scott F. Stoltenberg

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Philibert, R., Beach, S., Brody, G. (2014). The DNA Methylation Signature of Smoking: An Archetype for the Identification of Biomarkers for Behavioral Illness. In: Stoltenberg, S. (eds) Genes and the Motivation to Use Substances. Nebraska Symposium on Motivation, vol 61. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0653-6_6

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