Abstract
Fungal rhinosinusitis presents with several distinct clinical manifestations, determined by the presence or absence of tissue invasion as well as the host’s response to the fungus. Changing terminology and pathogenic theories create confusion in the proper classification, diagnosis, and management of fungal sinusitis. The contention that environmental fungi are the cause of most cases of chronic rhinosinusitis is another source of controversy. However, antifungal treatment does not appear to be effective for chronic rhinosinusitis. The diagnosis and treatment of fungal sinusitis usually requires a surgical approach, with ongoing medical management for some cases. Allergic fungal sinusitis is treated with anti-inflammatory agents, while antifungal agents are employed in cases of invasive fungal sinusitis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Hora JF. Primary aspergillosis of the paranasal sinuses and associated areas. Laryngoscope. 1965;75:768–73.
Katzenstein AL, Sale SR, Greenberger PA. Allergic Aspergillus rhinosinusitis: a newly recognized form of rhinosinusitis. J Allergy Clin Immunol. 1983;72:89–93.
Ferguson BJ. Definitions of fungal rhinosinusitis. Otolaryngol Clin North Am. 2000;33:227–35.
Stringer SP, Ryan MW. Chronic invasive fungal rhinosinusitis. Otolaryngol Clin North Am. 2000;33:375–87.
Schwietz LA, Gourley DS. Allergic fungal rhinosinusitis. Allergy Proc. 1992;13:3–6.
Talbot GH, Huang A, Provencher M. Invasive aspergillus rhinosinusitis in patients with acute leukemia. Rev Infect Dis. 1991;13:219–32.
Milosev B, el-Mahgoub S, Aal OA, et al. Primary aspergilloma of paranasal sinuses in the Sudan. A review of seventeen cases. Br J Surg. 1969;56:132–7.
Ponikau JU, Sherris DA, Kern EB, et al. The diagnosis and incidence of allergic fungal rhinosinusitis. Mayo Clin Proc. 1999;74:877–84.
Shin SH, Ponikau JU, Sherris DA, et al. Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungi. J Allergy Clin Immunol. 2004;114:1369–75.
Ponikau JU, Sherris DA, Weaver A, et al. Treatment of chronic rhinosinusitis with intranasal amphotericin B: a randomized, placebo-controlled, double-blind pilot trial. J Allergy Clin Immunol. 2005;115:125–31.
Fokkens WJ, van Drunen C, Georgalas C, et al. Role of fungi in pathogenesis of chronic rhinosinusitis: the hypothesis rejected. Curr Opin Otolaryngol Head Neck Surg. 2012;20(1):19–23.
Sacks PL, Harvey RJ, Rimmer J, et al. Topical and systemic antifungal therapy for the symptomatic treatment of chronic rhinosinusitis. Cochrane Database Syst Rev. 2011;8:CD008263.
Orlandi RR, Marple BF, Georgelas A, et al. Immunologic response to fungus is not universally associated with rhinosinusitis. Otolaryngol Head Neck Surg. 2009;141:750–6.e1–2.
Foreman A, Psaltis AJ, Tan LW, et al. Characterization of bacterial and fungal biofilms in chronic rhinosinusitis. Am J Rhinol Allergy. 2009;23:556–61.
Glass D, Amedee RG. Allergic fungal rhinosinusitis: a review. Ochsner J. 2011;11:271–5.
Buchheidt D, Hummel M, Schleiermacher D, et al. Current molecular diagnostic approaches to systemic infections with aspergillus species in patients with hematological malignancies. Leuk Lymphoma. 2004;45:463–8.
Lass-Florl C, Gunsilius E, Gastl G, et al. Clinical evaluation of Aspergillus-PCR for detection of invasive aspergillosis in immunosuppressed patients. Mycoses. 2005;48 Suppl 1:12–7.
Chakrabarti A, Denning DW, Ferguson BJ, et al. Fungal rhinosinusitis: a categorization and definitional schema addressing current controversies. Laryngoscope. 2009;119:1809–18.
Klossek JM, Serrano E, Peloquin L, et al. Functional endoscopic sinus surgery and 109 mycetomas of paranasal sinuses. Laryngoscope. 1997;107:112–7.
Ferreiro JA, Carlson BA, Cody 3rd DT. Paranasal sinus fungus balls. Head Neck. 1997;19:481–6.
Seo YJ, Kim J, Kim K, et al. Radiologic characteristics of sinonasal fungus ball: an analysis of 119 cases. Acta Radiol. 2011;52:790–5.
Ferguson BJ. Fungus balls of the paranasal sinuses. Otolaryngol Clin North Am. 2000;33:389–98.
Brook I. Recovery of aerobic and anaerobic bacteria in sinus fungal ball. Otolaryngol Head Neck Surg. 2011;145:851–2.
Manning SC, Schaefer SD, Close LG, et al. Culture-positive allergic fungal rhinosinusitis. Arch Otolaryngol Head Neck Surg. 1991;117:174–8.
Ferguson BJ, Barnes L, Bernstein JM, et al. Geographic variation in allergic fungal rhinosinusitis. Otolaryngol Clin North Am. 2000;33:441–9.
Stewart AE, Hunsaker DH. Fungus-specific IgG and IgE in allergic fungal rhinosinusitis. Otolaryngol Head Neck Surg. 2002;127:324–32.
Schubert MS, Goetz DW. Evaluation and treatment of allergic fungal rhinosinusitis. II. Treatment and follow-up. J Allergy Clin Immunol. 1998;102:395–402.
Horst M, Hejjaoui A, Horst V, et al. Double-blind, placebo-controlled rush immunotherapy with a standardized Alternaria extract. J Allergy Clin Immunol. 1990;85:460–72.
Bent 3rd JP, Kuhn FA. Diagnosis of allergic fungal rhinosinusitis. Otolaryngol Head Neck Surg. 1994;111:580–8.
Allphin AL, Strauss M, Abdul-Karim FW. Allergic fungal rhinosinusitis: problems in diagnosis and treatment. Laryngoscope. 1991;101:815–20.
Ferguson BJ. Eosinophilic mucin rhinosinusitis: a distinct clinicopathological entity. Laryngoscope. 2000;110:799–813.
Pant H, Kette FE, Smith WB, et al. Eosinophilic mucus chronic rhinosinusitis: clinical subgroups or a homogeneous pathogenic entity? Laryngoscope. 2006;116:1241–7.
McClay JE, Marple B, Kapadia L, et al. Clinical presentation of allergic fungal rhinosinusitis in children. Laryngoscope. 2002;112:565–9.
Marple BF. Allergic fungal rhinosinusitis: current theories and management strategies. Laryngoscope. 2001;111:1006–19.
Ghegan MD, Lee FS, Schlosser RJ. Incidence of skull base and orbital erosion in allergic fungal rhinosinusitis (AFRS) and non-AFRS. Otolaryngol Head Neck Surg. 2006;134:592–5.
Manning SC, Merkel M, Kriesel K, et al. Computed tomography and magnetic resonance diagnosis of allergic fungal rhinosinusitis. Laryngoscope. 1997;107:170–6.
Marple BF, Mabry RL. Allergic fungal rhinosinusitis: learning from our failures. Am J Rhinol. 2000;14:223–6.
Rupa V, Jacob M, Mathews MS, et al. A prospective, randomised, placebo-controlled trial of postoperative oral steroid in allergic fungal rhinosinusitis. Eur Arch Otorhinolaryngol. 2010;267:233–8.
Kuhn FA, Javer AR. Allergic fungal rhinosinusitis: a four-year follow-up. Am J Rhinol. 2000;14:149–56.
Ryan MW, Marple BF. Allergic fungal rhinosinusitis: diagnosis and management. Curr Opin Otolaryngol Head Neck Surg. 2007;15:18–22.
Joe SA, Thambi R, Huang J. A systematic review of the use of intranasal steroids in the treatment of chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2008;139:340–7.
Schubert MS. Antileukotriene therapy for allergic fungal rhinosinusitis. J Allergy Clin Immunol. 2001;108:466–7.
Jen A, Kacker A, Huang C, et al. Fluconazole nasal spray in the treatment of allergic fungal rhinosinusitis: a pilot study. Ear Nose Throat J. 2004;83(692):94–5.
Mabry RL, Marple BF, Folker RJ, et al. Immunotherapy for allergic fungal rhinosinusitis: three years’ experience. Otolaryngol Head Neck Surg. 1998;119:648–51.
Folker RJ, Marple BF, Mabry RL, et al. Treatment of allergic fungal rhinosinusitis: a comparison trial of postoperative immunotherapy with specific fungal antigens. Laryngoscope. 1998;108:1623–7.
Marple B, Newcomer M, Schwade N, et al. Natural history of allergic fungal rhinosinusitis: a 4- to 10-year follow-up. Otolaryngol Head Neck Surg. 2002;127:361–6.
Veress B, Malik OA, el-Tayeb AA, et al. Further observations on the primary paranasal aspergillus granuloma in the Sudan: a morphological study of 46 cases. Am J Trop Med Hyg. 1973;22:765–72.
Chakrabarti A, Sharma SC, Chandler J. Epidemiology and pathogenesis of paranasal sinus mycoses. Otolaryngol Head Neck Surg. 1992;107:745–50.
Reddy CE, Gupta AK, Singh P, et al. Imaging of granulomatous and chronic invasive fungal rhinosinusitis: comparison with allergic fungal rhinosinusitis. Otolaryngol Head Neck Surg. 2010;143:294–300.
Washburn RG, Kennedy DW, Begley MG, et al. Chronic fungal rhinosinusitis in apparently normal hosts. Medicine (Baltimore). 1988;67:231–47.
Gumaa SA, Mahgoub ES, Hay RJ. Post-operative responses of paranasal Aspergillus granuloma to itraconazole. Trans R Soc Trop Med Hyg. 1992;86:93–4.
Ferguson BJ. Mucormycosis of the nose and paranasal sinuses. Otolaryngol Clin North Am. 2000;33:349–65.
Gillespie MB, Huchton DM, O’Malley BW. Role of middle turbinate biopsy in the diagnosis of fulminant invasive fungal rhinosinusitis. Laryngoscope. 2000;110:1832–6.
DelGaudio JM, Swain Jr RE, Kingdom TT, et al. Computed tomographic findings in patients with invasive fungal rhinosinusitis. Arch Otolaryngol Head Neck Surg. 2003;129:236–40.
Malani PN, Kauffman CA. Prevention and prophylaxis of invasive fungal rhinosinusitis in the immunocompromised patient. Otolaryngol Clin North Am. 2000;33:301–12.
Goering P, Berlinger NT, Weisdorf DJ. Aggressive combined modality treatment of progressive sinonasal fungal infections in immunocompromised patients. Am J Med. 1988;85:619–23.
Blitzer A, Lawson W, Meyers BR, et al. Patient survival factors in paranasal sinus mucormycosis. Laryngoscope. 1980;90:635–48.
Gillespie MB, O’Malley Jr BW, Francis HW. An approach to fulminant invasive fungal rhinosinusitis in the immunocompromised host. Arch Otolaryngol Head Neck Surg. 1998;124:520–6.
Taxy JB, El-Zayaty S, Langerman A. Acute fungal rhinosinusitis: natural history and the role of frozen section. Am J Clin Pathol. 2009;132:86–93.
Patterson TS, Barton LL, Shehab ZM, et al. Amphotericin B lipid complex treatment of a leukemic child with disseminated Fusarium solani infection. Clin Pediatr (Phila). 1996;35:257–60.
Acknowledgments
The authors would like to thank Dr. Jason Mull, M.D., Assistant Professor, Pathology, University of Texas Southwestern Medical Center, for the histopathological figures used in this chapter.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Science+Business Media New York
About this chapter
Cite this chapter
Ryan, M.W., Hui, N.Y., Aloulah, M.O. (2014). Fungus in Sinus Disease. In: Chang, C., Incaudo, G., Gershwin, M. (eds) Diseases of the Sinuses. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0265-1_8
Download citation
DOI: https://doi.org/10.1007/978-1-4939-0265-1_8
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4939-0264-4
Online ISBN: 978-1-4939-0265-1
eBook Packages: MedicineMedicine (R0)