Abstract
Acute lymphoblastic leukemia and central nervous system (CNS) tumors are the two most common pediatric malignancies, accounting for two-thirds of all pediatric cancers (SEER data 2002–2006). Overall survival rate has improved significantly in the last four decades with the advancement of multidisciplinary treatment. Currently, 1 in 570 young adults between the ages of 20 and 34 years is a childhood cancer survivor, and many of these survivors experience chronic severe medical conditions from previous CNS-directed therapy. Survivors are at risk for late mortality, second neoplasms, neurological and neurosensory deficits, growth failure, endocrinopathies, impaired neurocognitive function, psychological stress and poor social outcomes. In this chapter, the risk factors, clinical presentations, surveillance and intervention of delayed CNS toxicities will be reviewed and discussed.
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Edwards, B. K., Brown, M. L., Wingo, P. A., Howe, H. L., Ward, E., Ries, L. A., et al. (2005). Annual report to the nation on the status of cancer, 1975–2002, featuring population-based trends in cancer treatment. Journal of the National Cancer Institute, 97, 1407–1427.
Smith, M. A., Seibel, N. L., Altekruse, S. F., Ries, L. A., Melbert, D. L., O’Leary, M., et al. (2010). Outcomes for children and adolescents with cancer: Challenges for the twenty-first century. Journal of Clinical Oncology, 28, 2625–2634.
Armstrong, G. T. (2010). Long-term survivors of childhood central nervous system malignancies: The experience of the Childhood Cancer Survivor Study. European Journal of Paediatric Neurology, 14, 298–303.
Ferner, R. E., Huson, S. M., Thomas, N., Moss, C., Willshaw, H., Evans, D. G., et al. (2007). Guidelines for the diagnosis and management of individuals with neurofibromatosis 1. Journal of Medical Genetics, 44, 81–88.
Ullrich, N. J., Robertson, R., Kinnamon, D. D., Scott, R. M., Kieran, M. W., Turner, C. D., et al. (2007). Moyamoya following cranial irradiation for primary brain tumors in children. Neurology, 68, 932–938.
Crawford, J. R., Rood, B. R., Rossi, C. T., & Vezina, G. (2009). Medulloblastoma associated with novel PTCH mutation as primary manifestation of Gorlin syndrome. Neurology, 72, 1618.
Evans, D. G., Farndon, P. A., Burnell, L. D., Gattamaneni, H. R., & Birch, J. M. (1991). The incidence of Gorlin syndrome in 173 consecutive cases of medulloblastoma. British Journal of Cancer, 64, 959–961.
Garre, M. L., Cama, A., Bagnasco, F., Morana, G., Giangaspero, F., Brisigotti, M., et al. (2009). Medulloblastoma variants: Age-dependent occurrence and relation to Gorlin syndrome – a new clinical perspective. Clinical Cancer Research, 15, 2463–2471.
Evans, D. G., Birch, J. M., Ramsden, R. T., Sharif, S., & Baser, M. E. (2006). Malignant transformation and new primary tumours after therapeutic radiation for benign disease: Substantial risks in certain tumour prone syndromes. Journal of Medical Genetics, 43, 289–294.
Gonzalez, K. D., Noltner, K. A., Buzin, C. H., Gu, D., Wen-Fong, C. Y., Nguyen, V. Q., et al. (2009). Beyond Li Fraumeni syndrome: Clinical characteristics of families with p53 germline mutations. Journal of Clinical Oncology, 27, 1250–1256.
Joerger, M., Koeberle, D., Neumann, H. P., & Gillessen, S. (2005). Von Hippel-Lindau disease–a rare disease important to recognize. Onkologie, 28, 159–163.
Mulhern, R. K., Palmer, S. L., Reddick, W. E., Glass, J. O., Kun, L. E., Taylor, J., et al. (2001). Risks of young age for selected neurocognitive deficits in medulloblastoma are associated with white matter loss. Journal of Clinical Oncology, 19, 472–479.
Fouladi, M., Gilger, E., Kocak, M., Wallace, D., Buchanan, G., Reeves, C., et al. (2005). Intellectual and functional outcome of children 3 years old or younger who have CNS malignancies. Journal of Clinical Oncology, 23, 7152–7160.
Harila-Saari, A. H., Lahteenmaki, P. M., Pukkala, E., Kyyronen, P., Lanning, M., & Sankila, R. (2007). Scholastic achievements of childhood leukemia patients: A nationwide, register-based study. Journal of Clinical Oncology, 25, 3518–3524.
Lahteenmaki, P. M., Harila-Saari, A., Pukkala, E. I., Kyyronen, P., Salmi, T. T., & Sankila, R. (2007). Scholastic achievements of children with brain tumors at the end of comprehensive education: A nationwide, register-based study. Neurology, 69, 296–305.
Armstrong, G. T., Stovall, M., & Robison, L. L. (2010). Long-term effects of radiation exposure among adult survivors of childhood cancer: Results from the childhood cancer survivor study. Radiation Research, 174, 840–850.
Nathan, P. C., Greenberg, M. L., Ness, K. K., Hudson, M. M., Mertens, A. C., Mahoney, M. C., et al. (2008). Medical care in long-term survivors of childhood cancer: A report from the childhood cancer survivor study. Journal of Clinical Oncology, 26, 4401–4409.
Pui, C. H., & Howard, S. C. (2008). Current management and challenges of malignant disease in the CNS in paediatric leukaemia. The Lancet Oncology, 9, 257–268.
Ater, J. L., Moore, B. D., 3rd, Francis, D. J., Castillo, R., Slopis, J., & Copeland, D. R. (1996). Correlation of medical and neurosurgical events with neuropsychological status in children at diagnosis of astrocytoma: Utilization of a neurological severity score. Journal of Child Neurology, 11, 462–469.
Robertson, P. L., Muraszko, K. M., Holmes, E. J., Sposto, R., Packer, R. J., Gajjar, A., et al. (2006). Incidence and severity of postoperative cerebellar mutism syndrome in children with medulloblastoma: A prospective study by the Children’s Oncology Group. Journal of Neurosurgery, 105, 444–451.
Palmer, S. L., Hassall, T., Evankovich, K., Mabbott, D. J., Bonner, M., Deluca, C., et al. (2010). Neurocognitive outcome 12 months following cerebellar mutism syndrome in pediatric patients with medulloblastoma. Neuro-Oncology, 12, 1311–1317.
Schultheiss, T. E. (1995). Cerebral radiation necrosis: Regarding Schultheiss et al., IJROBP 31:1093-1112;1995. International Journal of Radiation Oncology, Biology, and Physics, 32, 1269.
Reddick, W. E., Russell, J. M., Glass, J. O., Xiong, X., Mulhern, R. K., Langston, J. W., et al. (2000). Subtle white matter volume differences in children treated for medulloblastoma with conventional or reduced dose craniospinal irradiation. Magnetic Resonance Imaging, 18, 787–793.
Reddick, W. E., Glass, J. O., Palmer, S. L., Wu, S., Gajjar, A., Langston, J. W., et al. (2005). Atypical white matter volume development in children following craniospinal irradiation. Neuro-Oncology, 7, 12–19.
Packer, R. J., Meadows, A. T., Rorke, L. B., Goldwein, J. L., & D’Angio, G. (1987). Long-term sequelae of cancer treatment on the central nervous system in childhood. Medical and Pediatric Oncology, 15, 241–253.
Merchant, T. E., Goloubeva, O., Pritchard, D. L., Gaber, M. W., Xiong, X., Danish, R. K., et al. (2002). Radiation dose-volume effects on growth hormone secretion. International Journal of Radiation Oncology, Biology, and Physics, 52, 1264–1270.
Armstrong, G. T., Jain, N., Liu, W., Merchant, T. E., Stovall, M., Srivastava, D. K., et al. (2010). Region-specific radiotherapy and neuropsychological outcomes in adult survivors of childhood CNS malignancies. Neuro-Oncology, 12, 1173–1186.
Wara, W. M., Phillips, T. L., Sheline, G. E., & Schwade, J. G. (1975). Radiation tolerance of the spinal cord. Cancer, 35, 1558–1562.
Schiff, D., & Wen, P. (2006). Central nervous system toxicity from cancer therapies. Hematology/Oncology Clinics of North America, 20, 1377–1398.
Buizer, A. I., de Sonneville, L. M., & Veerman, A. J. (2009). Effects of chemotherapy on neurocognitive function in children with acute lymphoblastic leukemia: A critical review of the literature. Pediatric Blood & Cancer, 52, 447–454.
Copeland, D. R., Moore, B. D., 3rd, Francis, D. J., Jaffe, N., & Culbert, S. J. (1996). Neuropsychologic effects of chemotherapy on children with cancer: A longitudinal study. Journal of Clinical Oncology, 14, 2826–2835.
Moleski, M. (2000). Neuropsychological, neuroanatomical, and neurophysiological consequences of CNS chemotherapy for acute lymphoblastic leukemia. Archives of Clinical Neuropsychology, 15, 603–630.
Linnebank, M., Pels, H., Kleczar, N., Farmand, S., Fliessbach, K., Urbach, H., et al. (2005). MTX-induced white matter changes are associated with polymorphisms of methionine metabolism. Neurology, 64, 912–913.
Winick, N. (2011). Neurocognitive outcome in survivors of pediatric cancer. Current Opinion in Pediatrics, 23, 27–33.
Rollins, N. K., Winick, N., Gimi, B., Chia, J., & Wang, J. (2009). Comparison of leukemic and controls subjects using diffusion tensor imaging. Presented at the ASPHO meeting. Pediatr Blood Cancer, doi: 10.1002/pbc.
Anderson, F. S., & Kunin-Batson, A. S. (2009). Neurocognitive late effects of chemotherapy in children: The past 10 years of research on brain structure and function. Pediatric Blood & Cancer, 52, 159–164.
Reddick, W. E., Glass, J. O., Helton, K. J., Langston, J. W., Li, C. S., & Pui, C. H. (2005). A quantitative MR imaging assessment of leukoencephalopathy in children treated for acute lymphoblastic leukemia without irradiation. American Journal of Neuroradiology, 26, 2371–2377.
Wilson, D. A., Nitschke, R., Bowman, M. E., Chaffin, M. J., Sexauer, C. L., & Prince, J. R. (1991). Transient white matter changes on MR images in children undergoing chemotherapy for acute lymphocytic leukemia: Correlation with neuropsychologic deficiencies. Radiology, 180, 205–209.
Grewal, S., Merchant, T., Reymond, R., McInerney, M., Hodge, C., & Shearer, P. (2010). Auditory late effects of childhood cancer therapy: A report from the Children’s Oncology Group. Pediatrics, 125, e938–e950.
Goldsby, R. E., Liu, Q., Nathan, P. C., Bowers, D. C., Yeaton-Massey, A., Raber, S. H., et al. (2010). Late-occurring neurologic sequelae in adult survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. Journal of Clinical Oncology, 28(2), 324–331.
Tubergen, D. G., Gilchrist, G. S., O’Brien, R. T., Coccia, P. F., Sather, H. N., Waskerwitz, M. J., et al. (1993). Prevention of CNS disease in intermediate-risk acute lymphoblastic leukemia: Comparison of cranial radiation and intrathecal methotrexate and the importance of systemic therapy: A Childrens Cancer Group report. Journal of Clinical Oncology, 11, 520–526.
Packer, R. J., Goldwein, J., Nicholson, H. S., Vezina, L. G., Allen, J. C., Ris, M. D., et al. (1999). Treatment of children with medulloblastomas with reduced-dose craniospinal radiation therapy and adjuvant chemotherapy: A Children’s Cancer Group Study. Journal of Clinical Oncology, 17, 2127–2136.
Packer, R. J., & Finlay, J. L. (1996). Chemotherapy for childhood medulloblastoma and primitive neuroectodermal tumors. The Oncologist, 1, 381–393.
Sands, S. A., Oberg, J. A., Gardner, S. L., Whiteley, J. A., Glade-Bender, J. L., & Finlay, J. L. (2010). Neuropsychological functioning of children treated with intensive chemotherapy followed by myeloablative consolidation chemotherapy and autologous hematopoietic cell rescue for newly diagnosed CNS tumors: An analysis of the Head Start II survivors. Pediatric Blood & Cancer, 54, 429–436.
Sands, S. A., Pasichow, K. P., Weiss, R., Garvin, J., Gardner, S., Dunkel, I. J., et al. (2011). Quality of life and behavioral follow-up study of Head Start I pediatric brain tumor survivors. Journal of Neuro-Oncology, 101, 287–295.
Conklin, H. M., Li, C., Xiong, X., Ogg, R. J., & Merchant, T. E. (2008). Predicting change in academic abilities after conformal radiation therapy for localized ependymoma. Journal of Clinical Oncology, 26, 3965–3970.
Packer, R. J., Gajjar, A., Vezina, G., Rorke-Adams, L., Burger, P. C., Robertson, P. L., et al. (2006). Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma. Journal of Clinical Oncology, 24, 4202–4208.
Armstrong, G. T., Conklin, H. M., Huang, S., Srivastava, D., Sanford, R., Ellison, D. W., et al. (2011). Survival and long-term health and cognitive outcomes after low-grade glioma. Neuro-Oncology, 13, 223–234.
Ness, K. K., Leisenring, W. M., Huang, S., Hudson, M. M., Gurney, J. G., Whelan, K., et al. (2009). Predictors of inactive lifestyle among adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Cancer, 115, 1984–1994.
Foreman, N. K., Faestel, P. M., Pearson, J., Disabato, J., Poole, M., Wilkening, G., et al. (1999). Health status in 52 long-term survivors of pediatric brain tumors. Journal of Neuro-Oncology, 41, 47–53.
Zebrack, B. J., & Chesler, M. A. (2002). Quality of life in childhood cancer survivors. Psychooncology, 11, 132–141.
Armstrong, G. T., Liu, Q., Yasui, Y., Huang, S., Ness, K. K., Leisenring, W., et al. (2009). Long-term outcomes among adult survivors of childhood central nervous system malignancies in the Childhood Cancer Survivor Study. Journal of the National Cancer Institute, 101, 946–958.
Oeffinger, K. C., Mertens, A. C., Sklar, C. A., Kawashima, T., Hudson, M. M., Meadows, A. T., et al. (2006). Chronic health conditions in adult survivors of childhood cancer. The New England Journal of Medicine, 355, 1572–1582.
Mody, R., Li, S., Dover, D. C., Sallan, S., Leisenring, W., Oeffinger, K. C., et al. (2008). Twenty-five-year follow-up among survivors of childhood acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study. Blood, 111, 5515–5523.
Brownstein, C. M., Mertens, A. C., Mitby, P. A., Stovall, M., Qin, J., Heller, G., et al. (2004). Factors that affect final height and change in height standard deviation scores in survivors of childhood cancer treated with growth hormone: a report from the childhood cancer survivor study. The Journal of Clinical Endocrinology and Metabolism, 89, 4422–4427.
Gurney, J. G., Kadan-Lottick, N. S., Packer, R. J., Neglia, J. P., Sklar, C. A., Punyko, J. A., et al. (2003). Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors: Childhood Cancer Survivor Study. Cancer, 97, 663–673.
Green, D. M., Nolan, V. G., Kawashima, T., Stovall, M., Donaldson, S. S., Srivastava, D., et al. (2011). Decreased fertility among female childhood cancer survivors who received 22–27 Gy hypothalamic/pituitary irradiation: A report from the Childhood Cancer Survivor Study. Fertility and Sterility, 95, 1922–1927.
Sklar, C. A., & Constine, L. S. (1995). Chronic neuroendocrinological sequelae of radiation therapy. International Journal of Radiation Oncology, Biology, and Physics, 31, 1113–1121.
Armstrong, G. T., Whitton, J. A., Gajjar, A., Kun, L. E., Chow, E. J., Stovall, M., et al. (2009). Abnormal timing of menarche in survivors of central nervous system tumors: A report from the Childhood Cancer Survivor Study. Cancer, 115, 2562–2570.
Haddy, R. I., & Haddy, T. B. (2010). Lifetime follow-up care after childhood cancer. Journal of the American Board of Family Medicine, 23, 647–654.
Gurney, J. G., Ness, K. K., Stovall, M., Wolden, S., Punyko, J. A., Neglia, J. P., et al. (2003). Final height and body mass index among adult survivors of childhood brain cancer: Childhood Cancer Survivor Study. The Journal of Clinical Endocrinology and Metabolism, 88, 4731–4739.
Reddick, W. E., Glass, J. O., Helton, K. J., Langston, J. W., Xiong, X., Wu, S., et al. (2005). Prevalence of leukoencephalopathy in children treated for acute lymphoblastic leukemia with high-dose methotrexate. American Journal of Neuroradiology, 26, 1263–1269.
Rubnitz, J. E., Relling, M. V., Harrison, P. L., Sandlund, J. T., Ribeiro, R. C., Rivera, G. K., et al. (1998). Transient encephalopathy following high-dose methotrexate treatment in childhood acute lymphoblastic leukemia. Leukemia, 12, 1176–1181.
Packer, R. J., Gurney, J. G., Punyko, J. A., Donaldson, S. S., Inskip, P. D., Stovall, M., et al. (2003). Long-term neurologic and neurosensory sequelae in adult survivors of a childhood brain tumor: Childhood Cancer Survivor Study. Journal of Clinical Oncology, 21, 3255–3261.
Bowers, D. C., Liu, Y., Leisenring, W., McNeil, E., Stovall, M., Gurney, J. G., et al. (2006). Late-occurring stroke among long-term survivors of childhood leukemia and brain tumors: A report from the Childhood Cancer Survivor Study. Journal of Clinical Oncology, 24, 5277–5282.
Kranick, S. M., Campen, C. J., Kasner, S. E., Kessler, S. K., Zimmerman, R. A., Lustig, R. A., et al. (2013). Headache as a risk factor for neurovascular events in pediatric brain tumor patients. Neurology, 80(16), 1452–1456.
Whelan, K., Stratton, K., Kawashima, T., Leisenring, W., Hayashi, S., Waterbor, J., et al. (2011). Auditory complications in childhood cancer survivors: A report from the childhood cancer survivor study. Pediatric Blood & Cancer, 57, 126–134.
Goldwein, J. W. (1987). Radiation myelopathy: A review. Medical and Pediatric Oncology, 15, 89–95.
Askins, M. A., & Moore, B. D., 3rd. (2008). Preventing neurocognitive late effects in childhood cancer survivors. Journal of Child Neurology, 23, 1160–1171.
Reddick, W. E., Taghipour, D. J., Glass, J. O., Ashford, J., Xiong, X., Wu, S., et al. (2014). Prognostic factors that increase the risk for reduced white matter volumes and deficits in attention and learning for survivors of childhood cancers. Pediatric Blood & Cancer, 61(6), 1074–1079.
Ellenberg, L., Liu, Q., Gioia, G., Yasui, Y., Packer, R. J., Mertens, A., et al. (2009). Neurocognitive status in long-term survivors of childhood CNS malignancies: A report from the Childhood Cancer Survivor Study. Neuropsychology, 23, 705–717.
Mulhern, R. K., Hancock, J., Fairclough, D., & Kun, L. (1992). Neuropsychological status of children treated for brain tumors: A critical review and integrative analysis. Medical and Pediatric Oncology, 20, 181–191.
Oeffinger, K. C., Nathan, P. C., & Kremer, L. C. (2008). Challenges after curative treatment for childhood cancer and long-term follow up of survivors. Pediatric Clinics North America, 55, 251–273.
Radcliffe, J., Packer, R. J., Atkins, T. E., Bunin, G. R., Schut, L., Goldwein, J. W., et al. (1992). Three- and four-year cognitive outcome in children with noncortical brain tumors treated with whole-brain radiotherapy. Annals of Neurology, 32, 551–554.
Zeltzer, L. K., Recklitis, C., Buchbinder, D., Zebrack, B., Casillas, J., Tsao, J. C., et al. (2009). Psychological status in childhood cancer survivors: A report from the Childhood Cancer Survivor Study. Journal of Clinical Oncology, 27, 2396–2404.
Beebe, D. W., Ris, M. D., Armstrong, F. D., Fontanesi, J., Mulhern, R., Holmes, E., et al. (2005). Cognitive and adaptive outcome in low-grade pediatric cerebellar astrocytomas: Evidence of diminished cognitive and adaptive functioning in National Collaborative Research Studies (CCG 9891/POG 9130). Journal of Clinical Oncology, 23, 5198–5204.
Ronning, C., Sundet, K., Due-Tonnessen, B., Lundar, T., & Helseth, E. (2005). Persistent cognitive dysfunction secondary to cerebellar injury in patients treated for posterior fossa tumors in childhood. Pediatric Neurosurgery, 41, 15–21.
Karatekin, C., Lazareff, J. A., & Asarnow, R. F. (2000). Relevance of the cerebellar hemispheres for executive functions. Pediatric Neurology, 22, 106–112.
Aarsen, F. K., Paquier, P. F., Arts, W. F., Van Veelen, M. L., Michiels, E., Lequin, M., et al. (2009). Cognitive deficits and predictors 3 years after diagnosis of a pilocytic astrocytoma in childhood. Journal of Clinical Oncology, 27, 3526–3532.
Palmer, S. L., Goloubeva, O., Reddick, W. E., Glass, J. O., Gajjar, A., Kun, L., et al. (2001). Patterns of intellectual development among survivors of pediatric medulloblastoma: A longitudinal analysis. Journal of Clinical Oncology, 19, 2302–2308.
Maddrey, A. M., Bergeron, J. A., Lombardo, E. R., McDonald, N. K., Mulne, A. F., Barenberg, P. D., et al. (2005). Neuropsychological performance and quality of life of 10 year survivors of childhood medulloblastoma. Journal of Neuro-Oncology, 72, 245–253.
Palmer, S. L., Armstrong, C., Onar-Thomas, A., Wu, S., Wallace, D., Bonner, M. J., et al. (2013). Processing speed, attention, and working memory after treatment for medulloblastoma: An international, prospective, and longitudinal study. Journal of Clinical Oncology, 31, 3494–3500.
Schreiber, J. E., Gurney, J. G., Palmer, S. L., Bass, J. K., Wang, M., Chen, S., et al. (2014). Examination of risk factors for intellectual and academic outcomes following treatment for pediatric medulloblastoma. Neuro-Oncology, 16(8), 1129–1136.
Campbell, L. K., Scaduto, M., Sharp, W., Dufton, L., Van Slyke, D., Whitlock, J. A., et al. (2007). A meta-analysis of the neurocognitive sequelae of treatment for childhood acute lymphocytic leukemia. Pediatric Blood & Cancer, 49, 65–73.
Robinson, K. E., Livesay, K. L., Campbell, L. K., Scaduto, M., Cannistraci, C. J., Anderson, A. W., et al. (2010). Working memory in survivors of childhood acute lymphocytic leukemia: Functional neuroimaging analyses. Pediatric Blood & Cancer, 54, 585–590.
Harila, M. J., Winqvist, S., Lanning, M., Bloigu, R., & Harila-Saari, A. H. (2009). Progressive neurocognitive impairment in young adult survivors of childhood acute lymphoblastic leukemia. Pediatric Blood & Cancer, 53, 156–161.
Spiegler, B. J., Kennedy, K., Maze, R., Greenberg, M. L., Weitzman, S., Hitzler, J. K., et al. (2006). Comparison of long-term neurocognitive outcomes in young children with acute lymphoblastic leukemia treated with cranial radiation or high-dose or very high-dose intravenous methotrexate. Journal of Clinical Oncology, 24, 3858–3864.
Krull, K. R., Brinkman, T. M., Li, C., Armstrong, G. T., Ness, K. K., Srivastava, D. K., et al. (2013). Neurocognitive outcomes decades after treatment for childhood acute lymphoblastic leukemia: A report from the St Jude Lifetime Cohort Study. Journal of Clinical Oncology, 31, 4407–4415.
Zebrack, B. J., Gurney, J. G., Oeffinger, K., Whitton, J., Packer, R. J., Mertens, A., et al. (2004). Psychological outcomes in long-term survivors of childhood brain cancer: A report from the Childhood Cancer Survivor Study. Journal of Clinical Oncology, 22, 999–1006.
Ross, L., Johansen, C., Dalton, S. O., Mellemkjaer, L., Thomassen, L. H., Mortensen, P. B., et al. (2003). Psychiatric hospitalizations among survivors of cancer in childhood or adolescence. The New England Journal of Medicine, 349, 650–657.
Brinkman, T. M., et al. (2013). Suicide ideation in pediatric and adult survivors of childhood brain tumors. Journal of Neuro-Oncology, 113(3), 425–432.
Recklitis, C. J., Diller, L. R., et al. (2010). Suicide ideation in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Journal of Clinical Oncology, 28(4), 655–661.
Gurney, J. G., Krull, K. R., Kadan-Lottick, N., Nicholson, H. S., Nathan, P. C., Zebrack, B., et al. (2009). Social outcomes in the Childhood Cancer Survivor Study cohort. Journal of Clinical Oncology, 27, 2390–2395.
Ness, K. K., Morris, E. B., Nolan, V. G., Howell, C. R., Gilchrist, L. S., Stovall, M., et al. (2010). Physical performance limitations among adult survivors of childhood brain tumors. Cancer, 116, 3034–3044.
Pang, J. W., Friedman, D. L., Whitton, J. A., Stovall, M., Mertens, A. C., Robison, L. L., et al. (2008). Employment status among adult survivors in the Childhood Cancer Survivor Study. Pediatric Blood & Cancer, 50, 104–110.
Rauck, A. M., Green, D. M., Yasui, Y., Mertens, A., & Robison, L. L. (1999). Marriage in the survivors of childhood cancer: A preliminary description from the Childhood Cancer Survivor Study. Medical and Pediatric Oncology, 33, 60–63.
Pui, C. H., Cheng, C., Leung, W., Rai, S. N., Rivera, G. K., Sandlund, J. T., et al. (2003). Extended follow-up of long-term survivors of childhood acute lymphoblastic leukemia. The New England Journal of Medicine, 349, 640–649.
Haupt, R., Fears, T. R., Robison, L. L., Mills, J. L., Nicholson, H. S., Zeltzer, L. K., et al. (1994). Educational attainment in long-term survivors of childhood acute lymphoblastic leukemia. JAMA, 272, 1427–1432.
Meadows, A. T., Friedman, D. L., Neglia, J. P., Mertens, A. C., Donaldson, S. S., Stovall, M., et al. (2009). Second neoplasms in survivors of childhood cancer: Findings from the Childhood Cancer Survivor Study cohort. Journal of Clinical Oncology, 27, 2356–2362.
Neglia, J. P., Robison, L. L., Stovall, M., Liu, Y., Packer, R. J., Hammond, S., et al. (2006). New primary neoplasms of the central nervous system in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Journal of the National Cancer Institute, 98, 1528–1537.
Perkins, S. M., Fei, W., Mitra, N., Shinohara, E. T. (2013). Late causes of death in children treated for CNS malignancies. Journal of Neuro-Oncology, 115(1), 79–85.
Neglia, J. P., Meadows, A. T., Robison, L. L., Kim, T. H., Newton, W. A., Ruymann, F. B., et al. (1991). Second neoplasms after acute lymphoblastic leukemia in childhood. The New England Journal of Medicine, 325, 1330–1336.
Gleeson, H. K., & Shalet, S. M. (2004). The impact of cancer therapy on the endocrine system in survivors of childhood brain tumours. Endocrine-Related Cancer, 11, 589–602.
Mostoufi-Moab, S., & Grimberg, A. (2010). Pediatric brain tumor treatment: Growth consequences and their management. Pediatric Endocrinology Reviews, 8, 6–17.
Montgomery, M., Huang, S., Cox, C. L., Leisenring, W. M., Oeffinger, K. C., Hudson, M. M., et al. (2011). Physical therapy and chiropractic use among childhood cancer survivors with chronic disease: Impact on health-related quality of life. Journal of Cancer Survivorship, 5, 73–81.
Weinberg, D. G., Rahme, R. J., Aoun, S. G., Batjer, H. H., & Bendok, B. R. (2011). Moyamoya disease: Functional and neurocognitive outcomes in the pediatric and adult populations. Neurosurgical Focus, 30, E21.
Hardy, K. K., Willard, V. W., & Bonner, M. J. (2011). Computerized cognitive training in survivors of childhood cancer: A pilot study. Journal of Pediatric Oncology Nursing, 28, 27–33.
Berlucchi, G. (2011). Brain plasticity and cognitive neurorehabilitation. Neuropsychological Rehabilitation, 21, 560–578.
Conklin, H. M., Khan, R. B., Reddick, W. E., Helton, S., Brown, R., Howard, S. C., et al. (2007). Acute neurocognitive response to methylphenidate among survivors of childhood cancer: A randomized, double-blind, cross-over trial. Journal of Pediatric Psychology, 32, 1127–1139.
Kohli, S., Fisher, S. G., Tra, Y., Adams, M. J., Mapstone, M. E., Wesnes, K. A., et al. (2009). The effect of modafinil on cognitive function in breast cancer survivors. Cancer, 115, 2605–2616.
Daly, B. P., & Brown, R. T. (2007). Scholarly literature review: Management of neurocognitive late effects with stimulant medication. Journal of Pediatric Psychology, 32, 1111–1126.
Zebrack, B. J., Oeffinger, K. C., Hou, P., & Kaplan, S. (2006). Advocacy skills training for young adult cancer survivors: The young adult survivors conference at Camp Mak-a-Dream. Support Care Cancer, 14, 779–782.
Wolin, K. Y., Ruiz, J. R., Tuchman, H., & Lucia, A. (2010). Exercise in adult and pediatric hematological cancer survivors: An intervention review. Leukemia, 24, 1113–1120.
Brown, P. D., Pugh, S., Laack, N. N., Wefel, J. S., Khuntia, D., Meyers, C., et al. (2013). Radiation Therapy Oncology Group (RTOG). Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: A randomized, double-blind, placebo-controlled trial. Neuro-Oncology, 15(10), 1429–1437.
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Violet Shen, WP. (2015). Central Nervous System. In: Mucci, G., Torno, L. (eds) Handbook of Long Term Care of The Childhood Cancer Survivor. Specialty Topics in Pediatric Neuropsychology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7584-3_5
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DOI: https://doi.org/10.1007/978-1-4899-7584-3_5
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