Abstract
The outbreak of deadly hantavirus pulmonary syndrome (HPS) in the United States in 1993 (CDC., 1993) changed the concept of hemorrhagic fever with renal syndrome (HFRS) (WHO, 1983) because the clinical manifestations of this newly described hantavirus infection (Duchin et al., 1994) are quite different from the known typical forms of HFRS caused by Hantaan, Seoul, and Puumala viruses and because it occurred in the United States, where hantavirus disease had not been known to exist previously. Recent data on hantavirus disease show that HFRS occurs in the Old World and HPS, caused by novel hantaviruses, occurs in the New World. Epidemiological studies of HFRS progressed rapidly after the discovery of Hantaan virus, the etiologic agent of Korean hemorrhagic fever (Lee and Lee, 1976; Lee et al., 1978) through seroepidemiologic surveys of hantavirus infections in humans and in animals. It was long believed that HFRS only occurs in certain limited rural areas of Eurasia, such as Korea, China, Far East of Russia, and Northern Europe (Lee, 1982). Recent findings (Lee and van der Groen, 1989; Lee et al., 1990b), however, have shown that HFRS patients can be found not only in rural areas but also in urban cities in many parts of the world.
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References
Abercrombie, R. G., 1916, Observations on the acute phase of five hundred cases of war nephritis, J. R. Army Med. Corps 27:10.
Asasa, J. H., Tamura, M., and Kondo, K., 1987, Role of T-lymphocyte subset in protection and recovery from Hantaan virus infection in mice, J. Gen. Virol. 68:1961.
Bradford, J. R., 1916, Nephritis in the British troops in Flanders, Q. J. Med. 9:445.
Centers for Disease Control, 1993, Update: Outbreak of hantavirus infection—Southwestern United States, MMWR 42:421.
Couland, X., Chonaib, E., and Georges, A. J., 1987, First human case of hemorrhagic fever with renal syndrome in the Central African Republic, Trans. R. Soc. Trop. Med. Hyg. 81:686.
Desmyter, J., LeDuc, J. W., Johnson, K. M., Bresseur, F., Deckers, C., and van Ypersele de Strihou, C., 1983, Laboratory rat associated outbreak of hemorrhagic fever with renal syndrome due to Hantaan-like virus in Belgium, Lancet 2:1445.
Diglisic, G., Xiao, S., Gligic, A., Otradovic, M., Stojanovic, R., Velimirovic, D., Lukac, V., Rossi, C. A., and LeDuc, J. W., 1994, Isolation of a Puumala-like virus from Mus musculus captured in Yugoslavia and its association with severe hemorrhagic fever with renal syndrome, J. Infect. Dis. 169:204.
Dournon, E., Moriniere, B., Mattheson, S., Girard, P. M., Gonzales, J. P., Hirsh, F., and McCormick, J. B., 1984, HFRS after a wild rodent bite in the Haute Savoie and risk of exposure to Hantaan-like virus in a Paris laboratory, Lancet 1:676.
Duchin, J. S., Koster, F. T., Peters, C. J., Simpson, G. L., Tempest, B., Zaki, S. R., Ksiazek, T. G., Rollin, P. E., Nichol, S., Umland, E. T., Moolenaar, R. L., Reef, S. E., Nolte, K. B., Gallaher, M. M., Butler, J. C., Rreiman, R. F., and the Hantavirus Study Group, 1994, Hantavirus pulmonary syndrome: A clinical description of 17 patients with a newly recognized disease, N. Engl. J. M. 330:949.
Gavrilovskaya, I. N., Apekina, N. S., Miasnikov, Y. A., Yu, A., Bernshtein, A. D., Ryltseva, E. V., Gorbachkova, E. A., and Chumakov, M. P., 1983, Features of circulation of hemorrhagic fever with renal syndrome (HFRS) virus among small mammals in the European USSR, Arch. Virol. 75:313.
Gligic, A., Dimcovic, N., Xiao, S. Y., Yanagihara, R., and Gajdusek, D. C., 1992, Belgrade virus, a new hantavirus causing severe hemorrhagic fever with renal syndrome in Yugoslavia, J. Infect. Dis. 166:113.
Hjelle, B., Jenison, S., Torrez-Martinez, N., Yamada, T., Notte, K., Zumwalt, R., Macinnes, K., and Meyers, G., 1994, A novel hantavirus associated with an outbreak of fatal respiratory disease in the southwestern United States: Evolutionary relationships to known hantaviruses, J. Virol. 68:592.
Ishii, S., Ando, K., Watanabe, N., Murakami, R., Nagayama, T., and Ishikawa, T., 1942, Studies on Songo fever, Jpn. Army Med. J. 355:1755.
Jellison, W. H., 1971, Korean hemorrhagic fever and related diseases; a critical review and hypothesis, Mountain Press Publ. Co., p. 12.
Kasahara, S., Kitano, M., Kikuchi, H., Sakuyama, M., Kanazawa, K., Nezu, N., Yoshimara, M., and Kudo, T., 1944, Studies on pathogen of epidemic hemorrhagic fever, J. Jpn. Pathol. 34:1.
Kawamata, J., Yamanouchi, T., Miyamoto, H., Tanakashi, M., Yamanishi, K., Kurata, T., Dohmae, K., and Lee, H. W., 1987, Control of laboratory acquired hemorrhagic fever with renal syndrome (HFRS) in Japan, Lab. Anim. Sci. 37:431.
Kim, G. R., Lee, Y. T., and Park, C. H., 1994, A new natural reservoir of hantavirus; isolation of hantaviruses from lung tissues of bats, Arch. Virol. 134:85.
Kim, Y. S., and Lee, H. W., 1994, Persistence of antibodies after immunization with inactivated vaccine against HFRS among children and teenagers, J. Korean Clin. Pharmacol. 2:48.
Kurata, T., Sata, T., and Yamanishi, T., 1987, Viral pathology of hemorrhagic fever with renal syndrome virus infections in human and rodents, (abstract) 29th Int. Coll. Hantaviruses, Antwerp, p. 8.
Laehdevirta, J., 1971, Nephropathia epidemica in Finland. A clinical histological and epidemiological study, Ann. Clin. Res. 3(Suppl. 8):1.
Lee, C. H., Byun, K. S., Kim, W. J., Woo, Y. D., and Lee, H. W., 1992, Persistence of antibodies after immunization with an inactivated vaccine against HFRS in humans, J. Korean Soc. Microbiol. 22:239.
Lee, H. W., 1982, Korean hemorrhagic fever, Prog. Med. Virol. 28:96.
Lee, H. W., 1989, Hemorrhagic fever with renal syndrome in Korea, Rev. Infect. Dis. 2(Suppl. 4): S864.
Lee, H. W., and Johnson, K. M., 1982, Laboratory-acquired infection with Hantaan virus, J. Infect. Dis. 146:638.
Lee, H. W., and Lee, P. W., 1976, Korean hemorrhagic fever. I. Demonstration of causative antigen and antibodies, Korean J. Intern. Med. 19:371.
Lee, H. W., and van der Groen, G., 1989, Hemorrhagic fever with renal syndrome, Prog. Med. Virol. 36:62.
Lee, H. W., Lee, P. W., and Johnson, K. M., 1978, Isolation of the etiologic agent of Korean hemorrhagic fever, J. Infect. Dis. 137:298.
Lee, H. W., French, G. R., Lee, P. W., Baek, L. J., Tsuchiya, K., and Foulke, R. S., 1981a, Observations on natural and laboratory infection of rodents with the etiologic agent of Korean hemorrhagic fever, Am. J. Trop. Med. Hyg. 30:477.
Lee, H. W., Lee, P. W., Baek, L. J., Song, C. K., Seong, I. W., and Kim, J. H., 1981b, Intraspecific transmission of Hantaan virus, the etiologic agent of Korean haemorrhagic fever in the rodent Apodemus agrarius, Am. J. Trop. Med. Hyg. 30:1106.
Lee, H. W., Baek, L.J., and Kim, H. D., 1986, Studies on laboratory rat infection with Hantavirus in animal rooms of institutes in Seoul, J. Korean Soc. Virol. 16:113.
Lee, H. W., An, C. N., Song, J. W., Baek, L. J., Seo, T. J., and Park, S. C., 1990a, Field trial of an inactivated vaccine against hemorrhagic fever with renal syndrome in humans, Arch. Virol. (Suppl. 1):35.
Lee, H. W., Lee, P. W., Baek, L. J., and Chu, Y. K., 1990b, Geographical distribution of hemorrhagic fever with renal syndrome and hantaviruses, Arch. Virol. (Suppl. 1):5.
Lloyd, G., Bowen, E. T. W., Jones, N., and Pendry, A., 1984, HFRS outbreak associated with laboratory rats in UK, Lancet 1:1175.
Myhrman, G., 1951, Nephropathia epidemica, a new infectious disease in northern Scandinavia, Acta Med. Scand. 140:52.
Nernkar, V. R., Song, K., Gajdusek, D. C., and Yanagihara, R., 1993, Genetically distinct hantavirus in deer mice, Lancet 342:1058.
Niklasson, B., and LeDuc, J. W., 1987, Epidemiology of nephropathia epidemic in Sweden, J. Infect. Dis. 155:269.
Nuti, M., and Lee, H. W., 1991, Serological evidence of hantavirus infection in some tropical populations, Trans. R. Soc. Trop. Med. Hyg. 85:297.
Nuzum, E. O., Rossi, C. A., Stephenson, E. H., and LeDuc, J. W., 1988, Aerosol transmission of Hantaan and related viruses to laboratory rats, Am. Soc. Trop. Med. Hyg. 38:636.
Osterhaus, A., Spijkers, Van Steenis, B., and van der Groen, G., 1984, Hantavirus infection in Nederland, Ned. Tijdschr. Geneeskd. 128:2461.
Puthavathana, P., Lee, H. W., and Kang, C. Y., 1992, Typing of hantaviruses from five continents by polymerase chain reaction, Virus Res. 26:1.
Schmaljohn, C. S., Hasty, S. E., Dalrymple, J. M., LeDuc, J. W., Lee, H. W., von Bonsdorff, C. H., Brummer-Korvenkontio, M., Vaheri, A., Tsai, T. F., Regnery, H. L., Goldgaber, D., and Lee, P. W., 1985 Antigenic and genetic properties of viruses linked to hemorrhagic fever with renal syndrome, Science 227:1041.
Slonova, R. A., Tkachenko, E. A., Knshnarev, E. L., Dzagurova, T. K., and Astakova, T. I., 1992, Hantavirus isolation from birds, Acta Virol. 36:493.
Smadel, J. E., 1953, Epidemic hemorrhagic fever, Am. J. Public Health 43:1327.
Smorodintsev, A. A., Altchuler, I. S., Dunaevskii, M. I., Kiselev, M. V., Churilov, A. V., and Darshkevich, V., 1944, Etiology and clinical observation of hemorrhagic nephrosonephritis, Medgiz, Moscow, p. 38.
Song, G., Liao, H. X., Fu, J. L., Hang, C. S., Ni, D. S., Xia, Z. G., Lee, Z. Z., Su, T., Qiu, H. L., Zhang, Q. F., Gao, G. Z., and Zhao, Y. S., 1983, Etiologic studies of epidemic hemorrhagic fever (hemorrhagic fever with renal syndrome), J. Infect. Dis. 147:654.
Song, J., Baek, L. J., Gajdusek, D. C., Yanagihara, R., Gavrilovskaya, I., Luft, R. J., Machow, E. R., and Hjelle, B., 1994, Isolation of pathogenic hantavirus from white-footed mouse, Lancet 344:1637.
Tamura, M., 1964, Occurrence of epidemic hemorrhagic fever in Osaka city: First cases found in Japan with characteristic features of marked proteinuria, Biken J. 7:79.
Tkachenko, E. A., Ivanov, A. P., Donets, M. A., Miasnikov, Y. A., Ryltseva, E. V., Gaponova, L. K., Bashkirtsev, V. N., Okulova, N. M., and Drozdov, G. S., 1983, Potential reservoir and vectors of hemorrhagic fever with renal syndrome (HFRS) in the USSF., Ann. Soc. Belg. Med. Trop. 63:267.
Tkachenko, E. A., Ryltseva, E. V., and Miasnikov, Y. A., 1987, Study of circulation of hemorrhagic fever with renal syndrome virus among small mammals in the USSF., Probl. Virol. 6:709.
Tsai, T. F., 1987, Hemorrhagic fever with renal syndrome mode of transmission to humans, Lab. Anim. Sci. 37:428.
Umenai, T., Lee, H. W., Lee, P. W., Saito, T., Toyoda, T., Hongo, M., Yoshinage, K., Nobunaga, T., Horiuchi, T., and Ishida, N., 1979, Korean hemorrhagic fever in staff in an animal laboratory, Lancet 1:1314.
WHO, 1983, Hemorrhagic fever with renal syndrome, memorandum from a WHO meeting, Bull. WHO 61:269.
Yanagihara, R., and Gajdusek, D. C., 1987, Hemorrhagic fever with renal syndrome: Global epidemiology and ecology of hantavirus infection, Med. Virol. 6:171.
Yanagihara, R., Amyx, H. L., and Gajdusek, D. C., 1985, Experimental infection with Puumala virus, the etiologic agent of nephropathia epidemica, in bank voles, (Clethrionomys glareolus), J. Virol. 55:34.
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Lee, H.W. (1996). Epidemiology and Pathogenesis of Hemorrhagic Fever with Renal Syndrome. In: Elliott, R.M. (eds) The Bunyaviridae. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1364-7_10
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DOI: https://doi.org/10.1007/978-1-4899-1364-7_10
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