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Mucoadhesion and Characterization of Mucoadhesive Properties

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Mucosal Delivery of Biopharmaceuticals

Abstract

Mucoadhesive dosage forms may improve both in vitro and in vivo performance of products due to their propensity to enhance the retention of the dosage form at the site of application. The appropriate and reliable characterization of mucoadhesive systems is crucial to enable the identification of the appropriate formulations for in vivo use. In this chapter, the basic concepts of mucoadhesion and mucin structure are introduced. In addition, we present both in vitro and in vivo methods utilized for measurement of mucoadhesion including tensile and flow techniques. Despite the availability of several reported methods to characterize mucoadhesion, the mechanism of mucoadhesion is still insufficiently understood, and a universal technique for the measurement of mucoadhesion of dosage forms has not, as yet, been developed.

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Authors and Affiliations

  1. School of Pharmacy, The Queen’s University of Belfast, Medical Biology Centre, 97 Lisburn Road, BT9 7BL, Belfast, Northern Ireland, UK

    Tao Yu, Gavin P. Andrews & David S. Jones

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  1. Tao Yu
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  2. Gavin P. Andrews
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  3. David S. Jones
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Correspondence to David S. Jones .

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Editors and Affiliations

  1. IINFACTS - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Instituto Superior de Ciências da Saúde-Norte, CESPU, Gandra, Portugal

    José das Neves

  2. NEWTherapies Group, INEB – Instituto de Engenharia Biomédica, Porto, Portugal

    Bruno Sarmento

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© 2014 Springer Science+Business Media New York

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Yu, T., Andrews, G., Jones, D. (2014). Mucoadhesion and Characterization of Mucoadhesive Properties. In: das Neves, J., Sarmento, B. (eds) Mucosal Delivery of Biopharmaceuticals. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-9524-6_2

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