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Emerging Roles of Non-Coding RNAs in the Hypoxic Response

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Hypoxia and Cancer

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Hypoxia is a key component of the tumor microenvironment and represents a well-documented source of therapeutic failure in clinical oncology. Recent work has provided support to the idea that noncoding RNAs (ncRNAs), and in particular microRNAs (miRNAs), may play important roles in the adaptive response to low oxygen in tumors. Specifically, all published studies agree that the induction of microRNA-210 (miR-210) is a consistent feature of the hypoxic response in both normal and transformed cells. miR-210 is a robust target of hypoxia-inducible factor (HIF), and its overexpression has been detected in a variety of diseases with a hypoxic component, including most solid tumors. High levels of miR-210 have been linked to an in vivo hypoxic signature and to adverse prognosis in breast and pancreatic cancer patients. A wide variety of miR-210 targets have been identified, pointing to roles in mitochondrial metabolism, angiogenesis, differentiation, DNA damage response, and cell survival. Such targets are suspected to affect the development of tumors in multiple ways; therefore, an increased knowledge about miR-210’s actions may lead to novel diagnostic and therapeutic approaches in the cancer field.

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Acknowledgments

This work was supported by NIH R01 funding and the American Cancer Society (MI, USA), the Italian Ministry of Health (Ministero della Salute), and the Italian Association for Cancer Research (AIRC).

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Authors and Affiliations

  1. Department of Medicine, Indiana University, Indianapolis, IN, USA

    Mircea Ivan & Xiaoling Zhong

  2. Department of Microbiology and Immunology, Indiana University, Indianapolis, IN, USA

    Mircea Ivan

  3. Molecular Cardiology Laboratory, IRCCS-Policlinico San Donato, Via Morandi 30, 20097, Milan, Italy

    Simona Greco & Fabio Martelli

Authors
  1. Mircea Ivan
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  2. Xiaoling Zhong
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  3. Simona Greco
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  4. Fabio Martelli
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Correspondence to Mircea Ivan or Fabio Martelli .

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Editors and Affiliations

  1. Bristol-Myers Squibb, Princeton, New Jersey, USA

    Giovanni Melillo

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Ivan, M., Zhong, X., Greco, S., Martelli, F. (2014). Emerging Roles of Non-Coding RNAs in the Hypoxic Response. In: Melillo, G. (eds) Hypoxia and Cancer. Cancer Drug Discovery and Development. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9167-5_3

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