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Mechanisms of Immunopathology of Leishmaniasis

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Pathogenesis of Leishmaniasis

Abstract

While cutaneous leishmaniasis is characterized by lesions proximal to the site of the sandfly bite, visceral leishmaniasis is associated with immunopathology in the liver and spleen of the infected host. This chapter offers a brief overview of the immune responses generated during infections with cutaneous and visceral leishmaniasis. Insights on how the immune responses generated during cutaneous and visceral leishmaniasis coupled with other host- and pathogen-derived factors determine the clinical pathology and outcome of the disease are also discussed.

Gayathri Natarajan and Steve Oghumu are equal contributors of this chapter.

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Acknowledgments

This work was supported by National Institutes of Health grants and National Institute of Dental and Craniofacial Research Training Grant T32DE014320 awarded to S.O.

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    Authors and Affiliations

    1. Department of Microbiology, Ohio State University, Columbus, OH, USA

      Gayathri Natarajan

    2. Department of Pathology, Ohio State University Medical Center, 1645 Neil Avenue, Columbus, OH, 43210, USA

      Steve Oghumu, Sanjay Varikuti & Alexandria Thomas

    3. Department of Oral Biology, College of Dentistry, Ohio State University, Columbus, OH, USA

      Steve Oghumu

    4. Department of Pathology, The Ohio State University, Columbus, OH, USA

      Abhay Satoskar

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    1. Gayathri Natarajan
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    Correspondence to Abhay Satoskar .

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    1. Department of Pathology, The Ohio State University, Columbus, Ohio, USA

      Abhay Satoskar

    2. Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA

      Ravi Durvasula

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    Natarajan, G., Oghumu, S., Varikuti, S., Thomas, A., Satoskar, A. (2014). Mechanisms of Immunopathology of Leishmaniasis. In: Satoskar, A., Durvasula, R. (eds) Pathogenesis of Leishmaniasis. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9108-8_1

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