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Inflammation After Acute Brain Injuries Affects the Developing Brain Differently than the Adult Brain

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Immunological Mechanisms and Therapies in Brain Injuries and Stroke

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR,volume 6))

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Abstract

Emerging data show that the mechanisms of injury, including neuroinflammation, differ greatly in the immature brain and adult brain. This chapter will discuss the maturation-dependent contribution of glial and peripheral immune cells, differences in the blood–brain barrier structure and function in relation to injury, as well as the effect of immaturity on the function of several receptors on microglia/macrophages related to innate and acquired immune responses. We will discuss how age-related differential inflammatory and vascular responses to injury would impact development of treatments for newborns affected by stroke.

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Authors and Affiliations

  1. University of California San Francisco School of Medicine, San Francisco, CA, USA

    David Fernández-López

  2. Department of Neurology, University of California, San Francisco, CA, USA

    Zinaida S. Vexler

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  1. David Fernández-López
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  2. Zinaida S. Vexler
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Correspondence to Zinaida S. Vexler .

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Editors and Affiliations

  1. University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Jun Chen

  2. Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Xiaoming Hu

  3. Molecular Microbiology & Immunology, Oregon Health & Sciences University, Portland, Oregon, USA

    Mary Stenzel-Poore

  4. Loma Linda University, Loma Linda, California, USA

    John H. Zhang

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Fernández-López, D., Vexler, Z.S. (2014). Inflammation After Acute Brain Injuries Affects the Developing Brain Differently than the Adult Brain. In: Chen, J., Hu, X., Stenzel-Poore, M., Zhang, J. (eds) Immunological Mechanisms and Therapies in Brain Injuries and Stroke. Springer Series in Translational Stroke Research, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8915-3_9

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