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The Critical Roles of Immune Cells in Acute Brain Injuries

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Immunological Mechanisms and Therapies in Brain Injuries and Stroke

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR,volume 6))

Abstract

Acute brain injuries elicit prompt and robust immune responses characterized by the activation of local glial cells and mobilization of peripheral leukocytes. The activation of immune cells originally aims to clear the brain of cellular debris and promote brain repair; however, the immune system can also propel and propagate neuronal cell death when overactivated. Understanding the function of each type of immune cells in the acute brain injuries and their mechanisms of action promises to unveil effective immunomodulatory therapies that beneficially regulate post-injury immune responses. In this chapter, we discuss in detail how immune cells are recruited and/or activated in the injured brain and how they contribute to the evolvement of brain damage.

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Authors and Affiliations

  1. Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA

    Peiying Li, Yu Gan, Leilei Mao, Jun Chen & Xiaoming Hu

  2. Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, USA

    Rehana Leak

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  1. Peiying Li
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  2. Yu Gan
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  3. Leilei Mao
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  4. Rehana Leak
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  5. Jun Chen
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  6. Xiaoming Hu
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Correspondence to Xiaoming Hu .

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Editors and Affiliations

  1. University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Jun Chen

  2. Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Xiaoming Hu

  3. Molecular Microbiology & Immunology, Oregon Health & Sciences University, Portland, Oregon, USA

    Mary Stenzel-Poore

  4. Loma Linda University, Loma Linda, California, USA

    John H. Zhang

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Li, P., Gan, Y., Mao, L., Leak, R., Chen, J., Hu, X. (2014). The Critical Roles of Immune Cells in Acute Brain Injuries. In: Chen, J., Hu, X., Stenzel-Poore, M., Zhang, J. (eds) Immunological Mechanisms and Therapies in Brain Injuries and Stroke. Springer Series in Translational Stroke Research, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8915-3_2

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