Abstract
A hamartoma is a nonneoplastic heterotopia composed of an overgrowth of cytologically normal, mature cells in an abnormal, disorganized architectural pattern. Pathophysiological outcomes and differential diagnoses will depend upon area of involvement. It is a low-incidence disorder, more commonly found in young children and men. Diagnosis is based upon histopathological findings. Treatment is typically complete excision when possible, though it will depend upon the site of the tumor and the associated effects.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Windfuhr JP. Laryngeal hamartoma. Acta Otolaryngol. 2004;124:301–8.
Kizilkilic O, Yalcin O, Yildirim T, Sener L, Parmaksiz G, Erdogan B. Hypotahlamic hamartoma associated with a craniopharyngeal canal. Am J Neuroradiol. 2005;26:65–7.
Mizuguchi M, Takashima S. Neuropathology of tuberous sclerosis. Brain Dev. 2001;23:508–15.
Lamb RF, Roy C, Diefenbach TJ, Vinters HV, Johnson MW, Jay DG, et al. The TSC1 tumor suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho. Nat Cell Biol. 2000;2:281–7.
Wienecke R, Konig A, DeClue JE. Identification of tuberin, the tuberous sclerosis-2 product. Tubern possesses specific Rap1GAP activity. J Biol Chem. 1995;270:16409–14.
Kim JE, Kim HJ, Kim JH, Ko YH, Chung SK. Nasal chondromesenchymal hamartoma: CT and MR imaging findings. Korean J Radiol. 2009;10:416–9.
Horn C, Thaker HM, Tampakopoulou DA, De Serres LM, Keller JL, Haddad J. Tongue lesions in the pediatric population. Otolaryngol Head Neck Surg. 2001;124:164–9.
Jakubikova J, Harustiak S, Galbavy S, Chebenova M. Laryngeal hamartoma: surgical management. Int J Pediatr Otorhi. 1999;50:145–9.
Gross E, Chen MK, Hollabaugh RS, Joyner RE. Tracheal hamartoma: report of a child with a neck mass. J Pediatr Surg. 1996;31:1584–5.
Baget S, Francois A, Andrieu-Guitrancourt J, Marie JP, Dehesdin D. Hamartoma of the middle ear: a case study. Int J Pediatr Otorhi. 2003;67:287–91.
Abdulhamid I, Rabah R. Endobronchial chondromatous hamartoma in an infant. Pediatr Pulmonol. 2003;35:67–9.
Weinberger MS, Pransky SM, Krous HF. Fibrous hamartoma of infancy presenting as a perspiring neck mass. Int J Pediatr Otorhi. 1993;26:173–6.
Gajda M, Zagolski O, Jasztal A, Lis GJ, Pyka-Fosciak G, Litwin JA. Respiratory epithelial adenomatoid hamartoma of the anterior nasal septum a rare localization of an unusual tumour in a child: a case report. Cases J. 2009;2:8151.
Finitsis S, Giavroglou C, Potsi S, Constantinidis I, Mpaltatzidis A, Rachovitsas D, Tzioufa V. Nasal chondromesenchymal hamartoma in a child. Cardiovasc Intervent Radiol. 2009;32:593–7.
Dickey GE, Sotelo-Avila C. Fibrous hamartoma of infancy: current review. Pediat Devel Path. 1999;2:236–43.
Agrawal CS, Agrawal S, Sinha A. Fibrous hamartoma of infancy: a case report. Acta Derm Venereol. 2004;85:276–7.
Kramer U, Spector S, Nasser W, Siomin V, Fried I, Constantini S. Surgical treatment of hypothalamic hamartoma and refractory seizures. Pediatr Neurosurg. 2001;34:40–2.
Debeneix C, Bourgeois M, Trivin C, Sainte-Rose C, Brauner R. Hypothalamic hamartoma: comparison of clinical presentation and magnetic resonance images. Horm Res. 2001;56:12–8.
Fannon EM, Pride H. Asymptomatic plaque on the chin of a 10-year-old girl. Arch Dermatol. 2000;136:1263–8.
Terris MH, Billman GF, Pransky SM. Nasal hamartoma: case report and review of the literature. Int J Pediatr Otorhi. 1993;28:83–8.
. Johnson C, Nagaraj U, Esguerra J, Wasdahl D, Wurzbach D. Nasal chondromesenchymal hamartoma: radiographic and histopathologic analysis of a rare pediatric tumor. Pediatr Radiol. 2007;37:101–4.
Zachariou Z, Beiler HA, Roth H, Daum R. A rare case of an antenatally diagnosed tumor of the neck—a hamartoma of the thyroid gland. Journal Pediatr Surg. 1996;31:1294–6.
Olnes SQ, Schwartz RH, Bahadori RS. Diagnosis and management of the newborn and young infant who have nasal obstruction. Pediatr Rev. 2000;21:416–20.
Chapman KE, Kim DY, Rho JM, Ng YT, Kerrigan JF. Ketogenic diet in the treatment of seizures associated with hypothalamic hamartomas. Epilepsy Res. 2011;94:218–21.
Ng YT, Hastriter EV, Wethe J, Chaman KE, Prenger EC, Prigatano GP, Oppenheim T, Varland M, Rekate HL, Kerrigan JF. Surgical resection of hypothalamic hamartomas for severe behavioral symptoms. Epilepsy Behav. 2011;20:75–8.
Arisaka O, Negishi M, Numata M, Hoshi M, Kanazawa S, Oyama M, Nitta A, Suzumuara H, Kuribayashi T, Nakayama Y. Precocious puberty resulting from congenital hypothalamic hamartoma: persistent darkened areolae after birth as the hallmark of estrogen excess. Clin Pediatr. 2001;40:163–7.
Acknowledgments
I would like to thank Jenna M. Dargie, BS for helping research, prepare, and edit this manuscript, as well as Antonio R. Perez-Atayde, MD for preparing the histology slides.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Science+Business Media New York
About this chapter
Cite this chapter
Whittemore, K. (2014). Hamartomas. In: Rahbar, R., Rodriguez-Galindo, C., Meara, J., Smith, E., Perez-Atayde, A. (eds) Pediatric Head and Neck Tumors. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8755-5_23
Download citation
DOI: https://doi.org/10.1007/978-1-4614-8755-5_23
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-8754-8
Online ISBN: 978-1-4614-8755-5
eBook Packages: MedicineMedicine (R0)