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Blood Biomarkers for Acute CNS Insults: Traumatic Brain Injury and Stroke

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Vascular Mechanisms in CNS Trauma

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR,volume 5))

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Abstract

Proteins that are expressed in the central nervous system (CNS) are often detectable in peripheral blood and the search for biomarkers or biological signals for specific diseases and injury processes, including traumatic brain injury (TBI), has rapidly expanded. Currently no accurate biochemical assessment exists for objectively identifying the extent of damage following TBI. The ability to accurately determine the extent of initial severity of primary brain damage after TBI in the acute care setting is critical for the establishment of accurate neurologic prognosis and the guidance of appropriate therapeutic strategies (Nat Rev Neurol 9, 192–200, 2013; Neurotherapeutics 7, 100–114, 2010). This chapter will review the most current literature concerning the novel utility of blood biomarker assessment for the diagnosis and prognosis of patients with TBI.

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Authors and Affiliations

  1. Banyan Biomarkers, Inc., 13400 Progress Blvd., Alachua, FL, 32615, USA

    Ronald L. Hayes

  2. Banyan Biomarkers, Inc., Alachua, FL, USA

    Olena Glushakova

  3. Department of Neuroscience, University of Messina, Messina, Italy

    Stefania Mondello

Authors
  1. Olena Glushakova
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  2. Stefania Mondello
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  3. Ronald L. Hayes
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Correspondence to Ronald L. Hayes .

Editor information

Editors and Affiliations

  1. Departments of Neurology and Radiology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Eng H. Lo

  2. Department of Pediatrics, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Josephine Lok

  3. Department of Neurology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    MingMing Ning

  4. Department of Pediatrics, Massachusetts General Hospital Harbard Medical School, Boston, Massachusetts, USA

    Michael J. Whalen

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Glushakova, O., Mondello, S., Hayes, R.L. (2014). Blood Biomarkers for Acute CNS Insults: Traumatic Brain Injury and Stroke. In: Lo, E., Lok, J., Ning, M., Whalen, M. (eds) Vascular Mechanisms in CNS Trauma. Springer Series in Translational Stroke Research, vol 5. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8690-9_17

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