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Stem Cells for Neurovascular Repair in CNS Trauma

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Vascular Mechanisms in CNS Trauma

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR,volume 5))

Abstract

Stem cells exert therapeutic effects for central nervous system (CNS) trauma. Accumulating evidence reveals that stem cell-based therapies for CNS trauma can be achieved via transplantation of exogenous stem cells or stimulation of endogenous stem cells from the neurogenic niches of subventricular zone and subgranular zone, or recruited from the bone marrow through peripheral circulation. In this chapter, we review the different sources of stem cells that have been tested in animal models of CNS trauma, highlighting the research progress on stem cell-based therapeutics in stroke and their extension to traumatic brain injury (TBI). In addition, we discuss specific mechanisms of action, in particular neurovascular repair by endothelial progenitor cells, as key translational research for advancing the clinical applications of stem cells for CNS trauma.

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Disclosures/Conflict of Interests: CVB is supported by NIH NINDS 5U01NS055914-04 and NIH NINDS R01NS071956-01, James and Esther King Foundation for Biomedical Research Program, and receives research grant support for his projects on bone marrow stem cell therapy for stroke from SanBio Inc., Celgene Cellular Therapeutics, KMPHC and NeuralStem Inc.

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  1. Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Boulevard, Tampa, FL, 33612, USA

    Cesar V. Borlongan

  2. Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA

    Mibel M. Pabón, Travis Dailey, Naoki Tajiri, Kazutaka Shinozuka, Hiroto Ishikawa, Sandra Acosta & Yuji Kaneko

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  1. Mibel M. Pabón
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Correspondence to Cesar V. Borlongan .

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  1. Departments of Neurology and Radiology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Eng H. Lo

  2. Department of Pediatrics, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Josephine Lok

  3. Department of Neurology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    MingMing Ning

  4. Department of Pediatrics, Massachusetts General Hospital Harbard Medical School, Boston, Massachusetts, USA

    Michael J. Whalen

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Pabón, M.M. et al. (2014). Stem Cells for Neurovascular Repair in CNS Trauma. In: Lo, E., Lok, J., Ning, M., Whalen, M. (eds) Vascular Mechanisms in CNS Trauma. Springer Series in Translational Stroke Research, vol 5. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8690-9_11

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