Abstract
Acetylation of lysine residues on histones has been known for almost 50 years and is the most characterized posttranslational modification of chromatin. It is known to have a direct impact on the structure of chromatin as well as to play a signaling role to regulate the association of factors to specific genomic loci. Thus, it is not surprising that histone acetylation plays critical regulatory roles in all major nuclear processes, including gene expression, DNA repair, and replication. Here, we present an overview of the current state of knowledge on the role of histone acetylation in chromatin structure and function during DNA-based processes. We cover the functions of protein complexes involved in the addition and the removal of this mark on chromatin and how it is recognized as a signal. We also present how acetylation is functionally linked to other histone modifications. Finally, we discuss recent developments connecting histone acetylation to metabolism and aging as well as targeted drug discoveries aimed at treating human diseases.
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Abbreviations
- Acetyl-CoA:
-
Acetyl coenzyme A
- ADA:
-
Transcriptional adaptor
- Asf1:
-
Anti-silencing function protein 1
- Bdf1:
-
Bromodomain factor 1
- BET:
-
Bromodomain and extraterminal domain
- Brd:
-
Bromodomain
- CBP:
-
CREB-binding protein
- Chd1:
-
Chromodomain-helicase-DNA-binding protein 1
- ChIP:
-
Chromatin immunoprecipitation
- CoASH:
-
Coenzyme A
- CoREST:
-
Corepressor of RE1 silencing transcription factor 1
- DSB:
-
Double-strand break
- Esa1:
-
Essential Sas2-related acetyltransferase 1
- ESC:
-
Embryonic stem cell
- Gcn5:
-
General control nonderepressible-5
- Gcn5L:
-
General control nonderepressible-5 long isoform
- GNAT:
-
Gcn5-related N-acetyltransferase
- HAT:
-
Histone acetyltransferase
- HBO1:
-
Histone acetyltransferase binding to ORC1
- Hda1-3:
-
Histone deacetylase 1-3
- HDAC:
-
Histone deacetylase
- Hos1-3:
-
Hda one similar 1-3
- HR:
-
Homologous recombination
- Hst1-4:
-
Homolog of sir two 1-4
- ING1-5:
-
Inhibitor of growth protein 1-5
- KAT:
-
Lysine (K)-acetyltransferase
- MOF:
-
Males-absent on the first protein
- MORF:
-
Monocytic leukemia zinc finger protein-related factor
- MOZ:
-
Monocytic leukemia zinc finger protein
- MSL:
-
Male-specific lethal
- MYST:
-
MOZ-Ybf2/Sas3-Sas2-TIP60
- NAD+ :
-
Nicotinamide adenine dinucleotide
- N-CoR:
-
Nuclear receptor corepressor
- NER:
-
Nucleotide excision repair
- NFR:
-
Nucleosome-free region
- NHEJ:
-
Nonhomologous end joining
- NSL:
-
Nonspecific lethal
- NuA3:
-
Nucleosome acetyltransferase of H3
- NuA4:
-
Nucleosome acetyltransferase of H4
- NuRD:
-
Nucleosome remodeling and deacetylation
- PCAF:
-
p300/CBP associated factor
- PHD:
-
Plant homeodomain
- Pol II:
-
RNA polymerase II
- PTM:
-
Posttranslational modification
- Rpd3:
-
Reduced potassium dependency 3
- Rpd3S/L:
-
Rpd3 small/large complex
- Rtt109:
-
Regulator of Ty1 transposition protein 109
- SAGA:
-
Spt-Ada-Gcn5-acetyltransferase
- Sas2-3:
-
Something about silencing 2-3
- Sin3(S/L):
-
Switch independent 3 (small/large)
- Sir2:
-
Silent information regulator 2
- Sirt1-7:
-
Silent information regulator two homolog 1-7
- SLIK:
-
SAGA-like
- SMRT:
-
Silencing mediator of retinoic acid and thyroid hormone receptor
- STAGA:
-
Spt-Taf9-Ada-Gcn5-acetyltransferase
- TFTC:
-
TBP-free TAFII complex
- Tip60:
-
Tat-interacting protein (60 kDa)
- TSA:
-
Trichostatin A
- TSS:
-
Transcription start site
- Yng2:
-
Yeast Ing1 homolog 2
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Acknowledgments
We apologize to our colleagues whose work could not be referenced due to space limitations. We thank Rhea Utley for correcting the text. Work in our lab was supported by grants from the Canadian Institutes of Health Research (CIHR, MOP-14308/64289). J. Côté holds a Canada Research Chair in Chromatin Biology and Molecular Epigenetics.
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Steunou, AL., Rossetto, D., Côté, J. (2014). Regulating Chromatin by Histone Acetylation. In: Workman, J., Abmayr, S. (eds) Fundamentals of Chromatin. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8624-4_4
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